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True spatio-temporal detection and e...

University of Michigan.

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True spatio-temporal detection and estimation for functional magnetic resonance imaging.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	True spatio-temporal detection and estimation for functional magnetic resonance imaging./
Author:	Noh, Joonki.
Description:	167 p.
Notes:	Advisers: Jeffrey A. Fessler; Victor Solo.
Contained By:	Dissertation Abstracts International68-11B.
Subject:	Engineering, Electronics and Electrical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287594
ISBN:	9780549306023

True spatio-temporal detection and estimation for functional magnetic resonance imaging.
Noh, Joonki.

True spatio-temporal detection and estimation for functional magnetic resonance imaging. - 167 p.

Advisers: Jeffrey A. Fessler; Victor Solo.

Thesis (Ph.D.)--University of Michigan, 2007.

The development of fast imaging in magnetic resonance imaging (MRI) makes it possible for researchers in various fields to investigate functional activities of the human brain with a unique combination of high spatial and temporal resolution. A significant task in functional MRI data analysis is to develop a detection statistic for activation, showing subject's localized brain responses to pre-specified stimuli. With rare exceptions in FMRI, these detection statistics have been derived from a, measurement model under two main assumptions: spatial independence and space-time separability of background noise.

ISBN: 9780549306023Subjects--Topical Terms:

626636
Engineering, Electronics and Electrical.

True spatio-temporal detection and estimation for functional magnetic resonance imaging.
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020 $a 9780549306023
035 $a (UMI)AAI3287594
035 $a AAI3287594
040 $a UMI $c UMI
100 1 $a Noh, Joonki. $3 1019073
245 1 0 $a True spatio-temporal detection and estimation for functional magnetic resonance imaging.
300 $a 167 p.
500 $a Advisers: Jeffrey A. Fessler; Victor Solo.
500 $a Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7554.
502 $a Thesis (Ph.D.)--University of Michigan, 2007.
520 $a The development of fast imaging in magnetic resonance imaging (MRI) makes it possible for researchers in various fields to investigate functional activities of the human brain with a unique combination of high spatial and temporal resolution. A significant task in functional MRI data analysis is to develop a detection statistic for activation, showing subject's localized brain responses to pre-specified stimuli. With rare exceptions in FMRI, these detection statistics have been derived from a, measurement model under two main assumptions: spatial independence and space-time separability of background noise.
520 $a One of the main goals of this thesis is to remove these assumptions which have been widely used in existing approaches. This thesis makes three main contributions: (1) a development of a detection statistic based on a spatiotemporally correlated noise model without space-time separability, (2) signal and noise modeling to implement the proposed detection statistic, (3) a development of a detection statistic that is robust to signal-to-noise ratio (SNR), Rician activation detection.
520 $a For the first time in FMRI, we develop a, properly formulated spatiotemporal detection statistic for activation, based on a spatiotemporally correlated noise model without space-time separability. The implementation of the developed detection statistic requires joint signal and noise modeling in three or four dimensions, which is non-trivial statistical model estimation. We complete the implementation with the parametric cepstrum, allowing dramatic reduction of computations in model fitting. These two are totally new contributions to FMRI data analysis. As byproducts, a novel test procedure for space-time separability is proposed and its asymptotic power is analyzed. The developed detection statistic and conventional statistics involving spatial smoothing by Gaussian kernel are compared through a, model comparison technique and asymptotic relative efficiency.
520 $a Most methods in FMRI data analysis are based on magnitude voxel time courses and their approximation by a Gaussian distribution. Since the magnitude images, in fact, obey Rician distribution and the Gaussian approximation is valid under a high SNR assumption, Gaussian modeling may perform poorly when SNR is low. In this thesis, we develop a detection statistic from a Rician distributed model, allowing a robust activation detection regardless of SNR.
590 $a School code: 0127.
650 4 $a Engineering, Electronics and Electrical. $3 626636
650 4 $a Engineering, System Science. $3 1018128
690 $a 0544
690 $a 0790
710 2 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 68-11B.
790 $a 0127
790 1 0 $a Fessler, Jeffrey A., $e advisor
790 1 0 $a Solo, Victor, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287594