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Synthesis, characterization and appl...

Liu, Jinrong.

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Synthesis, characterization and applications of new photocurable and biodegradable elastomers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis, characterization and applications of new photocurable and biodegradable elastomers./
Author:	Liu, Jinrong.
Description:	208 p.
Notes:	Advisers: Valerie V. S. Ashby; Ed T. Samulski.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3315687
ISBN:	9780549670841

Synthesis, characterization and applications of new photocurable and biodegradable elastomers.
Liu, Jinrong.

Synthesis, characterization and applications of new photocurable and biodegradable elastomers. - 208 p.

Advisers: Valerie V. S. Ashby; Ed T. Samulski.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2008.

Biodegradable elastomers have attracted a great deal of interest due to their potential applications in the biomedical field. Based on the advantages of the photocuring method, a new series of photocurable and biodegradable elastomers were designed. By using step growth polymerization, polyester liquids with different composition and molecular weights were synthesized. After endcapping with methacrylate groups, these liquids can be easily fabricated into completely amorphous elastomers by UV exposure for 1 min at room conditions. The prepared elastomers presented a wide range of mechanical properties (G = 0.1-10 MPa) and a fast degradation rate (16% after 5 week incubation in PBS). The in vitro and in vivo biocompatibility studies of the elastomers indicated that these elastomers were good candidates as tissue engineering scaffolds. Meanwhile, the functionality of these photocurable elastomers was expanded by incorporation of amine containing monomers, and new elastomers were prepared to explore their potential as drug carrier systems. Monodispersed elastomeric particles were fabricated out of these amine containing materials by PRINT(TM) technology. These particles showed pH sensitive drug release of Doxorubicin (a hydrophobic drug model) and Minocycline chloride (a hydrophilic drug model), and the release profiles can be further tuned by the incorporation of a disulfide crosslinker.

ISBN: 9780549670841Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Synthesis, characterization and applications of new photocurable and biodegradable elastomers.
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005 20100630
008 100630s2008 ||||||||||||||||| ||eng d
020 $a 9780549670841
035 $a (UMI)AAI3315687
035 $a AAI3315687
040 $a UMI $c UMI
100 1 $a Liu, Jinrong. $3 1018440
245 1 0 $a Synthesis, characterization and applications of new photocurable and biodegradable elastomers.
300 $a 208 p.
500 $a Advisers: Valerie V. S. Ashby; Ed T. Samulski.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4198.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2008.
520 $a Biodegradable elastomers have attracted a great deal of interest due to their potential applications in the biomedical field. Based on the advantages of the photocuring method, a new series of photocurable and biodegradable elastomers were designed. By using step growth polymerization, polyester liquids with different composition and molecular weights were synthesized. After endcapping with methacrylate groups, these liquids can be easily fabricated into completely amorphous elastomers by UV exposure for 1 min at room conditions. The prepared elastomers presented a wide range of mechanical properties (G = 0.1-10 MPa) and a fast degradation rate (16% after 5 week incubation in PBS). The in vitro and in vivo biocompatibility studies of the elastomers indicated that these elastomers were good candidates as tissue engineering scaffolds. Meanwhile, the functionality of these photocurable elastomers was expanded by incorporation of amine containing monomers, and new elastomers were prepared to explore their potential as drug carrier systems. Monodispersed elastomeric particles were fabricated out of these amine containing materials by PRINT(TM) technology. These particles showed pH sensitive drug release of Doxorubicin (a hydrophobic drug model) and Minocycline chloride (a hydrophilic drug model), and the release profiles can be further tuned by the incorporation of a disulfide crosslinker.
590 $a School code: 0153.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Materials Science. $3 1017759
690 $a 0495
690 $a 0794
710 2 $a The University of North Carolina at Chapel Hill. $b Materials Science. $3 1018439
773 0 $t Dissertation Abstracts International $g 69-07B.
790 $a 0153
790 1 0 $a Allbritton, Nancy $e committee member
790 1 0 $a Ashby, Valerie V. S., $e advisor
790 1 0 $a Samulski, Ed T., $e advisor
790 1 0 $a Sheiko, Sergei S. $e committee member
790 1 0 $a Wu, Yue $e committee member
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3315687