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Relationships between MDMA induced increases in extracellular glucose, glycogenolysis in brain and hyperthermia.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Relationships between MDMA induced increases in extracellular glucose, glycogenolysis in brain and hyperthermia./
Author:	Pachmerhiwala, Rashida.
Description:	47 p.
Notes:	Adviser: Gary A. Gudelsky.
Contained By:	Masters Abstracts International46-05.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1452393
ISBN:	9780549491699

Relationships between MDMA induced increases in extracellular glucose, glycogenolysis in brain and hyperthermia.
Pachmerhiwala, Rashida.

Relationships between MDMA induced increases in extracellular glucose, glycogenolysis in brain and hyperthermia. - 47 p.

Adviser: Gary A. Gudelsky.

Thesis (M.S.)--University of Cincinnati, 2008.

The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of 5-HT and/or NE pathways in the MDMA induced increase in extracellular glucose and glycogenolysis was assessed. The relationship of this response to MDMA induced hyperthermia also was determined. The administration of MDMA (10mg/kg, ip) resulted in a significant and sustained increase (50-100%) in the extracellular concentration of glucose not only in the striatum but also in the prefrontal cortex and hippocampus without altering peripheral blood glucose concentrations. Treatment of rats with fluoxetine (10mg/kg, ip) significantly attenuated the MDMA induced increase in extracellular glucose in the striatum but had no effect on MDMA induced hyperthermia or glycogenolysis. Treatment with prazosin (1mg/kg, ip) did not alter the glucose or glycogen responses to MDMA but completely suppressed the MDMA induced hyperthermia. Finally, propranolol (3mg/kg, ip) significantly attenuated the MDMA induced increase in extracellular glucose and glycogenolysis but did not alter MDMA induced hyperthermia. The present results suggest that MDMA increases extracellular glucose in multiple brain regions, and that this response involves both 5HT and NE mechanisms. Furthermore, beta adrenergic and alpha adrenergic receptors appear to contribute to MDMA-induced glycogenolysis and hyperthermia, respectively. Finally, hyperthermia, glycogenolysis and elevated extracellular glucose appear to be independent unrelated responses to acute MDMA administration.

ISBN: 9780549491699Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Relationships between MDMA induced increases in extracellular glucose, glycogenolysis in brain and hyperthermia.
LDR:02506nam 2200265 a 45 001 852160
005 20100629
008 100629s2008 ||||||||||||||||| ||eng d
020 $a 9780549491699
035 $a (UMI)AAI1452393
035 $a AAI1452393
040 $a UMI $c UMI
100 1 $a Pachmerhiwala, Rashida. $3 1017930
245 1 0 $a Relationships between MDMA induced increases in extracellular glucose, glycogenolysis in brain and hyperthermia.
300 $a 47 p.
500 $a Adviser: Gary A. Gudelsky.
500 $a Source: Masters Abstracts International, Volume: 46-05, page: 2662.
502 $a Thesis (M.S.)--University of Cincinnati, 2008.
520 $a The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of 5-HT and/or NE pathways in the MDMA induced increase in extracellular glucose and glycogenolysis was assessed. The relationship of this response to MDMA induced hyperthermia also was determined. The administration of MDMA (10mg/kg, ip) resulted in a significant and sustained increase (50-100%) in the extracellular concentration of glucose not only in the striatum but also in the prefrontal cortex and hippocampus without altering peripheral blood glucose concentrations. Treatment of rats with fluoxetine (10mg/kg, ip) significantly attenuated the MDMA induced increase in extracellular glucose in the striatum but had no effect on MDMA induced hyperthermia or glycogenolysis. Treatment with prazosin (1mg/kg, ip) did not alter the glucose or glycogen responses to MDMA but completely suppressed the MDMA induced hyperthermia. Finally, propranolol (3mg/kg, ip) significantly attenuated the MDMA induced increase in extracellular glucose and glycogenolysis but did not alter MDMA induced hyperthermia. The present results suggest that MDMA increases extracellular glucose in multiple brain regions, and that this response involves both 5HT and NE mechanisms. Furthermore, beta adrenergic and alpha adrenergic receptors appear to contribute to MDMA-induced glycogenolysis and hyperthermia, respectively. Finally, hyperthermia, glycogenolysis and elevated extracellular glucose appear to be independent unrelated responses to acute MDMA administration.
590 $a School code: 0045.
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
710 2 $a University of Cincinnati. $3 960309
773 0 $t Masters Abstracts International $g 46-05.
790 $a 0045
790 1 0 $a Gudelsky, Gary A., $e advisor
791 $a M.S.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1452393