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Extra-pituitary functions for GnRH.

University of Wyoming.

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Extra-pituitary functions for GnRH.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Extra-pituitary functions for GnRH./
作者:	Albertson, Asher J.
面頁冊數:	89 p.
附註:	Adviser: Donal C. Skinner.
Contained By:	Masters Abstracts International45-05.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1443264

Extra-pituitary functions for GnRH.
Albertson, Asher J.

Extra-pituitary functions for GnRH. - 89 p.

Adviser: Donal C. Skinner.

Thesis (M.S.)--University of Wyoming, 2007.

Gonadotropin Releasing Hormone (GnRH) is a hypothalamic decapeptide with a well known role as the primary regulatory of gonadal function. It exerts this regulation by controlling the release of the gonadotropins, Follicle Stimulating Hormone and Luteinizing Hormone from the anterior pituitary gland. While this role for GnRH is widely accepted, it is becoming apparent that GnRH may actually have a variety of vital roles in normal physiology. This has become evident from work implicating actions of GnRH in a variety of non-pituitary tissues. Most interesting of these tissues is the brain. We further elucidated potential extra-pituitary roles for GnRH within the brain by using immunohistochemistry to label the specific neural regions expressing the GnRH receptor. Additionally, we labeled pituitary gonadotrope cells for the GnRH receptor, something previously absent from the literature. Within the brain, the GnRH receptor was expressed in a variety of regions including the cerebral cortex, cerebellum, hippocampus, amygdala, olfactory system, preoptic region, lateral septum, and hypothalamus. It is clear that the GnRH receptor is widely distributed in a variety of neural regions leaving the potential that GnRH influences the activity of many neural pathways. Because of strong GnRH receptor immunoreactivity in neural regions vital to thermoregulation, we examined whether GnRH was capable of eliciting skin temperature change. First we designed a system in sheep through which peripheral skin temperature change could be reliably measured using lipopolysaccharide as a control inducer of transient temperature change. Next we performed large, IV, bolus injection of GnRH, however, no change in peripheral skin temperature was observed following such injections. While we were unable to induce peripheral temperature change in sheep using GnRH, further work must be done before the possibility that GnRH influences thermoregulation can be ruled out.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Extra-pituitary functions for GnRH.
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502 $a Thesis (M.S.)--University of Wyoming, 2007.
520 $a Gonadotropin Releasing Hormone (GnRH) is a hypothalamic decapeptide with a well known role as the primary regulatory of gonadal function. It exerts this regulation by controlling the release of the gonadotropins, Follicle Stimulating Hormone and Luteinizing Hormone from the anterior pituitary gland. While this role for GnRH is widely accepted, it is becoming apparent that GnRH may actually have a variety of vital roles in normal physiology. This has become evident from work implicating actions of GnRH in a variety of non-pituitary tissues. Most interesting of these tissues is the brain. We further elucidated potential extra-pituitary roles for GnRH within the brain by using immunohistochemistry to label the specific neural regions expressing the GnRH receptor. Additionally, we labeled pituitary gonadotrope cells for the GnRH receptor, something previously absent from the literature. Within the brain, the GnRH receptor was expressed in a variety of regions including the cerebral cortex, cerebellum, hippocampus, amygdala, olfactory system, preoptic region, lateral septum, and hypothalamus. It is clear that the GnRH receptor is widely distributed in a variety of neural regions leaving the potential that GnRH influences the activity of many neural pathways. Because of strong GnRH receptor immunoreactivity in neural regions vital to thermoregulation, we examined whether GnRH was capable of eliciting skin temperature change. First we designed a system in sheep through which peripheral skin temperature change could be reliably measured using lipopolysaccharide as a control inducer of transient temperature change. Next we performed large, IV, bolus injection of GnRH, however, no change in peripheral skin temperature was observed following such injections. While we were unable to induce peripheral temperature change in sheep using GnRH, further work must be done before the possibility that GnRH influences thermoregulation can be ruled out.
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