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The characteristic expression of cyt...

The University of Mississippi Medical Center.

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The characteristic expression of cytokines and toll-like receptors by CD3+ cells in leukemia.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The characteristic expression of cytokines and toll-like receptors by CD3+ cells in leukemia./
Author:	Webb, Rachel N.
Description:	93 p.
Notes:	Adviser: Julius Cruse.
Contained By:	Masters Abstracts International45-05.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1442977

The characteristic expression of cytokines and toll-like receptors by CD3+ cells in leukemia.
Webb, Rachel N.

The characteristic expression of cytokines and toll-like receptors by CD3+ cells in leukemia. - 93 p.

Adviser: Julius Cruse.

Thesis (M.S.)--The University of Mississippi Medical Center, 2007.

Toll-like receptors and cytokines function in immune regulation and thus may be dysregulated in disease. In the present study, 25 leukemia cases and 10 normal controls were analyzed by flow cytometry for differential cytokine and TLR expression. Percentages of CD3+ cells producing TNF-alpha, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12, and IFN-gamma and TLR3, TLR4, TLR8, and TLR9 expression levels in CD3+ cells were determined. Statistically significant differences between lymphocytic leukemic cases and normals were observed for all cytokines except IL-12. Differences in expression of all cytokines other than IL-6 and IFN-gamma proved to be statistically significant between myeloid leukemic and normal cases. IFN-gamma and IL-3 dual-staining was observed to be most prominent in leukemic samples. The increased expression level of TLR9 in leukemic cases compared to levels in normal controls was statistically significant. These results warrant further study of the mechanism and potential therapeutic value targeting these leukemic patterns.Subjects--Topical Terms:

1017686
Biology, Cell.

The characteristic expression of cytokines and toll-like receptors by CD3+ cells in leukemia.
LDR:01923nam 2200277 a 45 001 852119
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008 100629s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI1442977
035 $a AAI1442977
040 $a UMI $c UMI
100 1 $a Webb, Rachel N. $3 1017853
245 1 4 $a The characteristic expression of cytokines and toll-like receptors by CD3+ cells in leukemia.
300 $a 93 p.
500 $a Adviser: Julius Cruse.
500 $a Source: Masters Abstracts International, Volume: 45-05, page: 2465.
502 $a Thesis (M.S.)--The University of Mississippi Medical Center, 2007.
520 $a Toll-like receptors and cytokines function in immune regulation and thus may be dysregulated in disease. In the present study, 25 leukemia cases and 10 normal controls were analyzed by flow cytometry for differential cytokine and TLR expression. Percentages of CD3+ cells producing TNF-alpha, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12, and IFN-gamma and TLR3, TLR4, TLR8, and TLR9 expression levels in CD3+ cells were determined. Statistically significant differences between lymphocytic leukemic cases and normals were observed for all cytokines except IL-12. Differences in expression of all cytokines other than IL-6 and IFN-gamma proved to be statistically significant between myeloid leukemic and normal cases. IFN-gamma and IL-3 dual-staining was observed to be most prominent in leukemic samples. The increased expression level of TLR9 in leukemic cases compared to levels in normal controls was statistically significant. These results warrant further study of the mechanism and potential therapeutic value targeting these leukemic patterns.
590 $a School code: 0805.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0379
690 $a 0571
690 $a 0982
710 2 $a The University of Mississippi Medical Center. $3 1017852
773 0 $t Masters Abstracts International $g 45-05.
790 $a 0805
790 1 0 $a Cruse, Julius, $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1442977