東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The effects of microglial inactivati...

Texas Christian University.

Linked to FindBook

Google Book

Amazon

博客來

The effects of microglial inactivation and decreased prostaglandin synthesis on lipopolysaccharide-induced learning deficits.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effects of microglial inactivation and decreased prostaglandin synthesis on lipopolysaccharide-induced learning deficits./
Author:	Tarr, Andrew Justin.
Description:	52 p.
Notes:	Adviser: Gary W. Boehm.
Contained By:	Masters Abstracts International45-03.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1440522

The effects of microglial inactivation and decreased prostaglandin synthesis on lipopolysaccharide-induced learning deficits.
Tarr, Andrew Justin.

The effects of microglial inactivation and decreased prostaglandin synthesis on lipopolysaccharide-induced learning deficits. - 52 p.

Adviser: Gary W. Boehm.

Thesis (M.S.)--Texas Christian University, 2007.

Microglial inhibitors and non-selective COX inhibitors maybe possible treatments for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis by reducing cytokine overexpression. Experiments 1 & 2 attempted to further the understanding of the mechanisms of how proinflammatory cytokines contribute to learning/memory deficits seen after lipopolysaccharide administration and to the extent to which microglial cells play a role in this. Specifically, the present study investigated the role of prostaglandin production and microglial activation in the development of LPS-induced cognitive impairments. Experiment 1 consisted of a co-administration of minocycline and LPS to C57BL/6J male mice. Experiment 2 consisted of a co-administration of indomethacin and LPS also to C57BL/6J male mice. We hypothesized that minocycline and indomethacin would reduce central cytokine levels and reduce or eliminate the effects of LPS-induced anxiety and cognitive deficits in both elevated plus maze and 2-way active avoidance conditioning paradigms.Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The effects of microglial inactivation and decreased prostaglandin synthesis on lipopolysaccharide-induced learning deficits.
LDR:01995nam 2200289 a 45 001 852102
005 20100629
008 100629s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI1440522
035 $a AAI1440522
040 $a UMI $c UMI
100 1 $a Tarr, Andrew Justin. $3 1017820
245 1 4 $a The effects of microglial inactivation and decreased prostaglandin synthesis on lipopolysaccharide-induced learning deficits.
300 $a 52 p.
500 $a Adviser: Gary W. Boehm.
500 $a Source: Masters Abstracts International, Volume: 45-03, page: 1681.
502 $a Thesis (M.S.)--Texas Christian University, 2007.
520 $a Microglial inhibitors and non-selective COX inhibitors maybe possible treatments for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis by reducing cytokine overexpression. Experiments 1 & 2 attempted to further the understanding of the mechanisms of how proinflammatory cytokines contribute to learning/memory deficits seen after lipopolysaccharide administration and to the extent to which microglial cells play a role in this. Specifically, the present study investigated the role of prostaglandin production and microglial activation in the development of LPS-induced cognitive impairments. Experiment 1 consisted of a co-administration of minocycline and LPS to C57BL/6J male mice. Experiment 2 consisted of a co-administration of indomethacin and LPS also to C57BL/6J male mice. We hypothesized that minocycline and indomethacin would reduce central cytokine levels and reduce or eliminate the effects of LPS-induced anxiety and cognitive deficits in both elevated plus maze and 2-way active avoidance conditioning paradigms.
590 $a School code: 0229.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Psychology, Experimental. $3 517106
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0317
690 $a 0349
690 $a 0623
690 $a 0982
710 2 $a Texas Christian University. $3 1017819
773 0 $t Masters Abstracts International $g 45-03.
790 $a 0229
790 1 0 $a Boehm, Gary W., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1440522