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Fluid-Structure Interaction Modellin...

Bruneau, David Andrew,

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Fluid-Structure Interaction Modelling of High-Frequency Wall Vibrations in Intracranial Aneurysms /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Fluid-Structure Interaction Modelling of High-Frequency Wall Vibrations in Intracranial Aneurysms // David Andrew Bruneau.
Author:	Bruneau, David Andrew,
Description:	1 electronic resource (166 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
Contained By:	Dissertations Abstracts International86-05B.
Subject:	Biomechanics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31298444
ISBN:	9798342755528

Fluid-Structure Interaction Modelling of High-Frequency Wall Vibrations in Intracranial Aneurysms /
Bruneau, David Andrew,

Fluid-Structure Interaction Modelling of High-Frequency Wall Vibrations in Intracranial Aneurysms /David Andrew Bruneau. - 1 electronic resource (166 pages)

Source: Dissertations Abstracts International, Volume: 86-05, Section: B.

An intracranial aneurysm is an abnormal outpouching of a blood vessel inside the skull, present in over 3% of people. While aneurysm rupture is deadly, many do not rupture, and therefore there is a clinical need for predictors of growth or rupture for unruptured aneurysms discovered incidentally. Since the, 1960s, intracranial aneurysms have been known to produce sounds due to underlying vibrations, however, the mechanism driving the vibrations has been debated, with proposed mechanisms ranging from self-excitation by stable pulsatile flow, to vibration caused by laminar vortex-shedding or turbulent-like flow. This thesis uses recent advances in fluid-structure interaction (FSI) modelling to simulate aneurysm vibrations and reveal the underlying mechanics.Under a slowly increasing, steady inflow, we induced flow phenotypes ranging from stable flow, to harmonic vortex shedding, to turbulent-like flow, in two aneurysm geometries. Both vortex-shedding and turbulent-like flows induced vibrations at specific narrow-band frequencies (100 - 500 Hz) that corresponded with structural mode shapes. We then incorporated pulsatile flow and found that stable pulsatile flow did not induce vibrations, while underlying flow instabilities transmitted through the wall as broad-band, random vibrations (consistent with previously-described bruits), and the sac also exhibited distinct narrow-band vibrations at specific structural modes, which extended into diastole (consistent with previous clinical recordings of musical murmurs). Finally, we showed how aneurysm vibrations could be estimated by un-coupled computational fluid dynamics (CFD) and modal analysis. The modal frequencies observed in aneurysm FSI were predicted accurately by modal analysis, while CFD reasonably predicted the underlying flow instability. Furthermore, the bruit vibration amplitude could be estimated by a linear relationship with the amplitude of flow instability, while the amplitude of the first mode was estimated by a squared relationship with the amplitude of flow instability, combined with the concentration of flow instability at the modal frequency.Our results provide a plausible explanation for distinct intracranial aneurysm sounds, and a pathway towards estimating the likelihood of an individual aneurysm vibrating. Our enriched understanding of the deformation patterns and amplitudes of vibrating aneurysms can inform future mechanobiological experiments to quantify the role of vibrations in aneurysm growth and remodelling.

English

ISBN: 9798342755528Subjects--Topical Terms:

548685
Biomechanics.
Subjects--Index Terms:

Aneurysm

Fluid-Structure Interaction Modelling of High-Frequency Wall Vibrations in Intracranial Aneurysms /
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520 $a An intracranial aneurysm is an abnormal outpouching of a blood vessel inside the skull, present in over 3% of people. While aneurysm rupture is deadly, many do not rupture, and therefore there is a clinical need for predictors of growth or rupture for unruptured aneurysms discovered incidentally. Since the, 1960s, intracranial aneurysms have been known to produce sounds due to underlying vibrations, however, the mechanism driving the vibrations has been debated, with proposed mechanisms ranging from self-excitation by stable pulsatile flow, to vibration caused by laminar vortex-shedding or turbulent-like flow. This thesis uses recent advances in fluid-structure interaction (FSI) modelling to simulate aneurysm vibrations and reveal the underlying mechanics.Under a slowly increasing, steady inflow, we induced flow phenotypes ranging from stable flow, to harmonic vortex shedding, to turbulent-like flow, in two aneurysm geometries. Both vortex-shedding and turbulent-like flows induced vibrations at specific narrow-band frequencies (100 - 500 Hz) that corresponded with structural mode shapes. We then incorporated pulsatile flow and found that stable pulsatile flow did not induce vibrations, while underlying flow instabilities transmitted through the wall as broad-band, random vibrations (consistent with previously-described bruits), and the sac also exhibited distinct narrow-band vibrations at specific structural modes, which extended into diastole (consistent with previous clinical recordings of musical murmurs). Finally, we showed how aneurysm vibrations could be estimated by un-coupled computational fluid dynamics (CFD) and modal analysis. The modal frequencies observed in aneurysm FSI were predicted accurately by modal analysis, while CFD reasonably predicted the underlying flow instability. Furthermore, the bruit vibration amplitude could be estimated by a linear relationship with the amplitude of flow instability, while the amplitude of the first mode was estimated by a squared relationship with the amplitude of flow instability, combined with the concentration of flow instability at the modal frequency.Our results provide a plausible explanation for distinct intracranial aneurysm sounds, and a pathway towards estimating the likelihood of an individual aneurysm vibrating. Our enriched understanding of the deformation patterns and amplitudes of vibrating aneurysms can inform future mechanobiological experiments to quantify the role of vibrations in aneurysm growth and remodelling.
546 $a English
590 $a School code: 0779
650 4 $a Biomechanics. $3 548685
650 4 $a Fluid mechanics. $3 528155
650 4 $a Mechanical engineering. $3 649730
650 4 $a Industrial engineering. $3 526216
653 $a Aneurysm
653 $a Finite element method
653 $a Fluid-structure interaction
653 $a Hemodynamics
653 $a Spectral analysis
690 $a 0648
690 $a 0204
690 $a 0548
690 $a 0546
710 2 $a University of Toronto (Canada). $b Mechanical and Industrial Engineering. $e degree granting institution. $3 3819498
720 1 $a Steinman, David A. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-05B.
790 $a 0779
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31298444