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Synthesis and Characterization of So...

Alyaseen, Waleed,

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Synthesis and Characterization of Sodium Alginate and Polyacrylamide Based Hydrogel for Effective Encapsulation and Release of Pharmaceutical Agents /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis and Characterization of Sodium Alginate and Polyacrylamide Based Hydrogel for Effective Encapsulation and Release of Pharmaceutical Agents // Waleed Alyaseen.
Author:	Alyaseen, Waleed,
Description:	1 electronic resource (114 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-07.
Contained By:	Masters Abstracts International86-07.
Subject:	Chemical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31767206
ISBN:	9798302177612

Synthesis and Characterization of Sodium Alginate and Polyacrylamide Based Hydrogel for Effective Encapsulation and Release of Pharmaceutical Agents /
Alyaseen, Waleed,

Synthesis and Characterization of Sodium Alginate and Polyacrylamide Based Hydrogel for Effective Encapsulation and Release of Pharmaceutical Agents /Waleed Alyaseen. - 1 electronic resource (114 pages)

Source: Masters Abstracts International, Volume: 86-07.

This thesis investigates the synthesis, characterization, and applications of synthetic malleable hydrogels, specifically focusing on Sodium Alginate/Polyacrylamide (SA/PAAM) hydrogels for drug delivery systems in medical and cosmetic fields. The study highlights the development of stretchable hydrogels engineered for the controlled release of therapeutic agents, with Riboflavin (vitamin B2) serving as a model drug. The hydrogels exhibit a remarkable average swelling ratio of six times their dry volume when fully loaded, demonstrating their capacity to sustain the controlled release of pharmaceuticals. Release studies indicate that peak concentrations occur approximately 24 hours post-administration, following a diffusion-controlled release mechanism. Additionally, the research explores the encapsulation of antidepressant medications, specifically Venlafaxine Hydrochloride and Paroxetine Hydrochloride, utilizing the Free Radical Polymerization method. The synthesized hydrogels exhibited high porosity and excellent swelling properties, critical for maximizing drug encapsulation efficiency. Comprehensive drug release studies revealed sustained release profiles for both antidepressants, suggesting a controlled release mechanism advantageous for long-term therapeutic applications. The findings underscore the potential of SA/PAAM hydrogels as effective drug delivery platforms, with implications for improved patient compliance and treatment efficacy. Future research will focus on optimizing the hydrogel formulation to enhance drug loading and release kinetics, paving the way for advanced applications in drug delivery systems.

English

ISBN: 9798302177612Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

Polyacrylamide

Synthesis and Characterization of Sodium Alginate and Polyacrylamide Based Hydrogel for Effective Encapsulation and Release of Pharmaceutical Agents /
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100 1 $a Alyaseen, Waleed, $e author. $0 (orcid)0009-0001-7502-7473 $3 3829518
245 1 0 $a Synthesis and Characterization of Sodium Alginate and Polyacrylamide Based Hydrogel for Effective Encapsulation and Release of Pharmaceutical Agents / $c Waleed Alyaseen.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (114 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Masters Abstracts International, Volume: 86-07.
500 $a Advisors: Guzman, Roberto Committee members: Saez, Edwardo; Savagatrup, Suchol.
502 $b M.E. $c The University of Arizona $d 2024.
520 $a This thesis investigates the synthesis, characterization, and applications of synthetic malleable hydrogels, specifically focusing on Sodium Alginate/Polyacrylamide (SA/PAAM) hydrogels for drug delivery systems in medical and cosmetic fields. The study highlights the development of stretchable hydrogels engineered for the controlled release of therapeutic agents, with Riboflavin (vitamin B2) serving as a model drug. The hydrogels exhibit a remarkable average swelling ratio of six times their dry volume when fully loaded, demonstrating their capacity to sustain the controlled release of pharmaceuticals. Release studies indicate that peak concentrations occur approximately 24 hours post-administration, following a diffusion-controlled release mechanism. Additionally, the research explores the encapsulation of antidepressant medications, specifically Venlafaxine Hydrochloride and Paroxetine Hydrochloride, utilizing the Free Radical Polymerization method. The synthesized hydrogels exhibited high porosity and excellent swelling properties, critical for maximizing drug encapsulation efficiency. Comprehensive drug release studies revealed sustained release profiles for both antidepressants, suggesting a controlled release mechanism advantageous for long-term therapeutic applications. The findings underscore the potential of SA/PAAM hydrogels as effective drug delivery platforms, with implications for improved patient compliance and treatment efficacy. Future research will focus on optimizing the hydrogel formulation to enhance drug loading and release kinetics, paving the way for advanced applications in drug delivery systems.
546 $a English
590 $a School code: 0009
650 4 $a Chemical engineering. $3 560457
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Pharmaceutical sciences. $3 3173021
653 $a Polyacrylamide
653 $a Malleable hydrogels
653 $a Drug delivery
653 $a Polymerization
690 $a 0542
690 $a 0572
690 $a 0495
710 2 $a The University of Arizona. $b Chemical Engineering. $e degree granting institution. $3 3823734
720 1 $a Guzman, Roberto $e degree supervisor.
773 0 $t Masters Abstracts International $g 86-07.
790 $a 0009
791 $a M.E.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31767206