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A Biomimetic Study of Brain Concussion /

Wang, Qifu,

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A Biomimetic Study of Brain Concussion /

Record Type:	Electronic resources : Monograph/item
Title/Author:	A Biomimetic Study of Brain Concussion // Qifu Wang.
Author:	Wang, Qifu,
Description:	1 electronic resource (140 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
Subject:	Bioengineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31766361
ISBN:	9798302159151

A Biomimetic Study of Brain Concussion /
Wang, Qifu,

A Biomimetic Study of Brain Concussion /Qifu Wang. - 1 electronic resource (140 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Traumatic brain injuries (TBI) resulting from sudden impacts, such as car crashes or falls, represent a significant global health concern. Despite extensive research efforts, the mechanisms underlying brain injuries remain unclear, primarily due to the skull's opacity that hinders direct observation of the brain motion and deformation during impact. A review of the literature reveals a substantial knowledge gap in current concussion research: the role of cerebrospinal fluid (CSF) flow through the porous arachnoid trabeculae (AT) in the subarachnoid space (SAS) has been insufficiently explored. This dissertation develops a novel biomimetic approach to address this knowledge gap. Specifically, it will examine (1) the role of CSF on brain motion and deformation during rotational and translational impacts, and (2) the role of AT as the head is subject to translational impacts. The overarching goal of this dissertation is to better understand the fundamental mechanisms behind concussive brain injuries.A comprehensive research approach combining systematic, numerical, and experimental methods was developed to deepen understanding of TBI mechanisms. (1) Using a biomimetic head surrogate, we have examined the TBI mechanism due to translational and rotational impacts. Specifically, we experimentally captured the CSF pressurization during the impact process and relate it to the motion and deformation of the brain matter due to the impact on the skull. (2) Through a comprehensive experimental and numerical study, we investigated the deformation of a soft hydrogel ball immersed in a liquid environment, subjected to accelerating and decelerating rotational impacts. The study conclusively demonstrates that the Arbitrary Lagrange-Eulerian (ALE) method is a suitable approach for examining the mechanisms of TBI. (3) Utilizing a novel indentation system, we experimentally and theoretically examined the behavior of soft, porous media under impact. The insights gained from this work have inspired us to investigate the role of AT in brain concussions. (4) A biomimetic AT structure, created from porous foam, was strategically placed inside the head surrogate to investigate its potential as a protective layer during translational impacts. The resulting CSF pressurization, when compared to scenarios where AT are absent, clearly demonstrates the critical role of AT in mitigating impacts on brain tissues. The series of studies conducted herein have laid a solid foundation for uncovering the complex mechanisms of TBI. This foundational work is crucial for the development of more effective head protection systems, ultimately helping reduce the incidence and severity of concussive injuries across various fields.

English

ISBN: 9798302159151Subjects--Topical Terms:

657580
Bioengineering.
Subjects--Index Terms:

Brain concussion

A Biomimetic Study of Brain Concussion /
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520 $a Traumatic brain injuries (TBI) resulting from sudden impacts, such as car crashes or falls, represent a significant global health concern. Despite extensive research efforts, the mechanisms underlying brain injuries remain unclear, primarily due to the skull's opacity that hinders direct observation of the brain motion and deformation during impact. A review of the literature reveals a substantial knowledge gap in current concussion research: the role of cerebrospinal fluid (CSF) flow through the porous arachnoid trabeculae (AT) in the subarachnoid space (SAS) has been insufficiently explored. This dissertation develops a novel biomimetic approach to address this knowledge gap. Specifically, it will examine (1) the role of CSF on brain motion and deformation during rotational and translational impacts, and (2) the role of AT as the head is subject to translational impacts. The overarching goal of this dissertation is to better understand the fundamental mechanisms behind concussive brain injuries.A comprehensive research approach combining systematic, numerical, and experimental methods was developed to deepen understanding of TBI mechanisms. (1) Using a biomimetic head surrogate, we have examined the TBI mechanism due to translational and rotational impacts. Specifically, we experimentally captured the CSF pressurization during the impact process and relate it to the motion and deformation of the brain matter due to the impact on the skull. (2) Through a comprehensive experimental and numerical study, we investigated the deformation of a soft hydrogel ball immersed in a liquid environment, subjected to accelerating and decelerating rotational impacts. The study conclusively demonstrates that the Arbitrary Lagrange-Eulerian (ALE) method is a suitable approach for examining the mechanisms of TBI. (3) Utilizing a novel indentation system, we experimentally and theoretically examined the behavior of soft, porous media under impact. The insights gained from this work have inspired us to investigate the role of AT in brain concussions. (4) A biomimetic AT structure, created from porous foam, was strategically placed inside the head surrogate to investigate its potential as a protective layer during translational impacts. The resulting CSF pressurization, when compared to scenarios where AT are absent, clearly demonstrates the critical role of AT in mitigating impacts on brain tissues. The series of studies conducted herein have laid a solid foundation for uncovering the complex mechanisms of TBI. This foundational work is crucial for the development of more effective head protection systems, ultimately helping reduce the incidence and severity of concussive injuries across various fields.
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650 4 $a Neurosciences. $3 588700
650 4 $a Health sciences. $3 3168359
653 $a Brain concussion
653 $a Brain trabeculae
653 $a Digital image correlation
653 $a Head surrogate
653 $a Rotational/translational impacts
653 $a Traumatic brain injury
690 $a 0202
690 $a 0566
690 $a 0317
710 2 $a Villanova University. $b College of Engineering. $e degree granting institution. $3 3829517
720 1 $a Wu, Qianhong $e degree supervisor.
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791 $a Ph.D.
792 $a 2024
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