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Abaloparatide to Treat Alveolar Bone...

Latimer, Jessica Michelle,

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Abaloparatide to Treat Alveolar Bone Loss for Dental Implant Reconstruction /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Abaloparatide to Treat Alveolar Bone Loss for Dental Implant Reconstruction // Jessica Michelle Latimer.
Author:	Latimer, Jessica Michelle,
Description:	1 electronic resource (186 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
Contained By:	Dissertations Abstracts International85-11B.
Subject:	Dentistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30996351
ISBN:	9798382742809

Abaloparatide to Treat Alveolar Bone Loss for Dental Implant Reconstruction /
Latimer, Jessica Michelle,

Abaloparatide to Treat Alveolar Bone Loss for Dental Implant Reconstruction /Jessica Michelle Latimer. - 1 electronic resource (186 pages)

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

Systemic administration of ABL significantly reduces the risk of fragility fractures in the femur, hip, and vertebrae, but no data exists on the likely positive effects that could be exerted on alveolar bone of the jaws. Considering the mechanism of action in which ABL directly influences osteoblastic cell lines and the previous clinical data reporting a substantial treatment effect of TPD in the regeneration of periodontal defects, the osteoanabolic effect of ABL could be leveraged to enhance procedures that aim to regenerate alveolar bone.The preclinical investigations in the present report evaluate the potential of systemic ABL therapy to increase alveolar bone formation and bone mineral density (BMD), in applications of tooth extraction socket healing, implant osseointegration, and peri-implant regeneration. A series of two experiments were performed in female, Sprague-Dawley rats to assess the effects of ABL under conditions simulating: 1) osteoporosis, in animals that received ovariectomy surgery to induce bone loss via estrogen-deficiency and; 2) in healthy, young animals with normal bone metabolism. These experiments assess the biologic possibility that ABL may increase alveolar bone quality prior to implant placement, enhance primary dental implant fixation, and accelerate healing in dental implant therapy.

English

ISBN: 9798382742809Subjects--Topical Terms:

828971
Dentistry.
Subjects--Index Terms:

Anabolics

Abaloparatide to Treat Alveolar Bone Loss for Dental Implant Reconstruction /
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500 $a Advisors: Giannobile, William V. Committee members: Rosen, Vicki; Spector, Myron; Treister, Nathaniel.
502 $b D.M.Sc. $c Harvard University School of Dental Medicine $d 2024.
520 $a Systemic administration of ABL significantly reduces the risk of fragility fractures in the femur, hip, and vertebrae, but no data exists on the likely positive effects that could be exerted on alveolar bone of the jaws. Considering the mechanism of action in which ABL directly influences osteoblastic cell lines and the previous clinical data reporting a substantial treatment effect of TPD in the regeneration of periodontal defects, the osteoanabolic effect of ABL could be leveraged to enhance procedures that aim to regenerate alveolar bone.The preclinical investigations in the present report evaluate the potential of systemic ABL therapy to increase alveolar bone formation and bone mineral density (BMD), in applications of tooth extraction socket healing, implant osseointegration, and peri-implant regeneration. A series of two experiments were performed in female, Sprague-Dawley rats to assess the effects of ABL under conditions simulating: 1) osteoporosis, in animals that received ovariectomy surgery to induce bone loss via estrogen-deficiency and; 2) in healthy, young animals with normal bone metabolism. These experiments assess the biologic possibility that ABL may increase alveolar bone quality prior to implant placement, enhance primary dental implant fixation, and accelerate healing in dental implant therapy.
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590 $a School code: 2122
650 4 $a Dentistry. $3 828971
650 4 $a Biology. $3 522710
650 4 $a Medicine. $3 641104
653 $a Anabolics
653 $a Bone regeneration
653 $a Dental implants
653 $a Medical-dental integration
653 $a Osteoporosis
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710 2 $a Harvard University School of Dental Medicine. $b Periodontology. $e degree granting institution. $3 3829423
720 1 $a Giannobile, William V. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-11B.
790 $a 2122
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