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Muscle Protein Turnover in Health an...

Gugel, Jack,

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Muscle Protein Turnover in Health and Disease /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Muscle Protein Turnover in Health and Disease // Jack Gugel.
Author:	Gugel, Jack,
Description:	1 electronic resource (95 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 87-02, Section: B.
Contained By:	Dissertations Abstracts International87-02B.
Subject:	Molecular biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32169814
ISBN:	9798291578803

Muscle Protein Turnover in Health and Disease /
Gugel, Jack,

Muscle Protein Turnover in Health and Disease /Jack Gugel. - 1 electronic resource (95 pages)

Source: Dissertations Abstracts International, Volume: 87-02, Section: B.

Protein turnover is an essential cellular process in which old proteins are degraded and replaced with newly synthesized ones. Striated muscle, which includes cardiac and skeletal muscle, is responsible for over 50% of full body protein turnover. Dysregulation of protein turnover is implicated in muscle diseases ranging from sarcopenia to heart failure. And yet, how protein turnover rates differ between different muscle types and disease states remains incompletely understood. We used a combination of stable isotope labeling, proteomics, and imaging techniques to measure the half-lives of hundreds of individual muscle proteins and visualize protein longevity across four different muscle types. We observed muscle-type dependence of protein turnover, visualized protein age heterogeneity at multiple spatial scales, and identified previously unknown long-lived proteins in skeletal muscle. Finally, we applied these approaches to a mouse model of Muscular Dystrophy, where we demonstrated that dystrophic muscles have elevated rates of protein synthesis that can be partially reversed by treatment with a fast skeletal myosin inhibitor.

English

ISBN: 9798291578803Subjects--Topical Terms:

517296
Molecular biology.
Subjects--Index Terms:

Protein turnover

Muscle Protein Turnover in Health and Disease /
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500 $a Advisors: Leinwand, Leslie; Stowell, Michael Committee members: Park, Soyeon; Arrojo e Drigo, Rafael; Lau, Edward.
502 $b Ph.D. $c University of Colorado at Boulder $d 2025.
520 $a Protein turnover is an essential cellular process in which old proteins are degraded and replaced with newly synthesized ones. Striated muscle, which includes cardiac and skeletal muscle, is responsible for over 50% of full body protein turnover. Dysregulation of protein turnover is implicated in muscle diseases ranging from sarcopenia to heart failure. And yet, how protein turnover rates differ between different muscle types and disease states remains incompletely understood. We used a combination of stable isotope labeling, proteomics, and imaging techniques to measure the half-lives of hundreds of individual muscle proteins and visualize protein longevity across four different muscle types. We observed muscle-type dependence of protein turnover, visualized protein age heterogeneity at multiple spatial scales, and identified previously unknown long-lived proteins in skeletal muscle. Finally, we applied these approaches to a mouse model of Muscular Dystrophy, where we demonstrated that dystrophic muscles have elevated rates of protein synthesis that can be partially reversed by treatment with a fast skeletal myosin inhibitor.
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650 4 $a Physiology. $3 518431
650 4 $a Biology. $3 522710
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653 $a Protein turnover
653 $a Skeletal myosin inhibitor
653 $a Protein synthesis
653 $a Muscular Dystrophy
653 $a Striated muscle
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792 $a 2025
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