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Investigating the Role of Maternal M...

Cinzori, Maria E.,

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Investigating the Role of Maternal Mitochondria in Pregnancy: Implications for Fetal Growth and Gestational Length /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigating the Role of Maternal Mitochondria in Pregnancy: Implications for Fetal Growth and Gestational Length // Maria E Cinzori.
作者:	Cinzori, Maria E.,
面頁冊數:	1 electronic resource (52 pages)
附註:	Source: Masters Abstracts International, Volume: 86-01.
Contained By:	Masters Abstracts International86-01.
標題:	Epidemiology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31482095
ISBN:	9798383287163

Investigating the Role of Maternal Mitochondria in Pregnancy: Implications for Fetal Growth and Gestational Length /
Cinzori, Maria E.,

Investigating the Role of Maternal Mitochondria in Pregnancy: Implications for Fetal Growth and Gestational Length /Maria E Cinzori. - 1 electronic resource (52 pages)

Source: Masters Abstracts International, Volume: 86-01.

Background: Little is understood about the role of mitochondria in pregnancy-related adaptations. Therefore, we evaluated associations of maternal early-to-mid pregnancy mitochondrial DNA copy number (mtDNAcn) and mtDNA methylation with birth size and gestational length.Methods: Michigan women (n=396) provided venous bloodspots at median 11 weeks gestation to quantify mtDNAcn marker NADH-ubiquinone oxidoreductase chain 1 (ND1) using real-time quantitative PCR and mtDNA methylation at several regions within four mitochondria-specific genes using pyrosequencing: MTTF (mt-TF/RNR1 locus), DLOOP (D-loop promoter region, heavy strand), CYTB (cytochrome b), and LDLR (D-loop promoter region, light strand). We abstracted gestational length and birthweight from birth certificates and calculated birthweight z-scores using published references. We used multivariable linear regression to evaluate associations of mtDNAcn and mtDNA methylation with birthweight and birthweight z-scores. Cox Proportional Hazards Models (PHMs) and quantile regression characterized associations of mitochondrial measures with gestational length. We also considered differences by fetal sex.Results: Using linear regression and Cox PHMs, mtDNAcn was not associated with birth outcomes, whereas associations of mtDNA methylation with birth outcomes were inconsistent. However, using quantile regression, mtDNAcn was associated with shorter gestation in female newborns at the upper quantiles of gestational length, but with longer gestational length in males at the lower quantiles of gestational length. Maternal LDLR, DLOOP, and MTTF methylation was associated with longer gestational length in females at the upper quantiles and in males at lower gestational length quantiles. Conclusions: Maternal mtDNAcn and mtDNA methylation were associated with gestational length in babies born comparatively early or late, which could reflect adaptations in mitochondrial processes that regulate the length of gestation.

English

ISBN: 9798383287163Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

Methylation

Investigating the Role of Maternal Mitochondria in Pregnancy: Implications for Fetal Growth and Gestational Length /
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500 $a Includes supplementary digital materials.
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520 $a Background: Little is understood about the role of mitochondria in pregnancy-related adaptations. Therefore, we evaluated associations of maternal early-to-mid pregnancy mitochondrial DNA copy number (mtDNAcn) and mtDNA methylation with birth size and gestational length.Methods: Michigan women (n=396) provided venous bloodspots at median 11 weeks gestation to quantify mtDNAcn marker NADH-ubiquinone oxidoreductase chain 1 (ND1) using real-time quantitative PCR and mtDNA methylation at several regions within four mitochondria-specific genes using pyrosequencing: MTTF (mt-TF/RNR1 locus), DLOOP (D-loop promoter region, heavy strand), CYTB (cytochrome b), and LDLR (D-loop promoter region, light strand). We abstracted gestational length and birthweight from birth certificates and calculated birthweight z-scores using published references. We used multivariable linear regression to evaluate associations of mtDNAcn and mtDNA methylation with birthweight and birthweight z-scores. Cox Proportional Hazards Models (PHMs) and quantile regression characterized associations of mitochondrial measures with gestational length. We also considered differences by fetal sex.Results: Using linear regression and Cox PHMs, mtDNAcn was not associated with birth outcomes, whereas associations of mtDNA methylation with birth outcomes were inconsistent. However, using quantile regression, mtDNAcn was associated with shorter gestation in female newborns at the upper quantiles of gestational length, but with longer gestational length in males at the lower quantiles of gestational length. Maternal LDLR, DLOOP, and MTTF methylation was associated with longer gestational length in females at the upper quantiles and in males at lower gestational length quantiles. Conclusions: Maternal mtDNAcn and mtDNA methylation were associated with gestational length in babies born comparatively early or late, which could reflect adaptations in mitochondrial processes that regulate the length of gestation.
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650 4 $a Obstetrics. $3 634501
653 $a Methylation
653 $a Mitochondria
653 $a Pregnancy
653 $a Gestational length
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690 $a 0769
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710 2 $a Michigan State University. $b Epidemiology - Master of Science. $e degree granting institution. $3 3829089
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773 0 $t Masters Abstracts International $g 86-01.
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