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Metabolic Reprogramming in Gut Micro...

Li, Lingjun,

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Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics // Lingjun Li.
Author:	Li, Lingjun,
Description:	1 electronic resource (76 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-11.
Contained By:	Masters Abstracts International86-11.
Subject:	Nutrition. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31997298
ISBN:	9798314876404

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /
Li, Lingjun,

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /Lingjun Li. - 1 electronic resource (76 pages)

Source: Masters Abstracts International, Volume: 86-11.

Microplastics (MPs), typically less than 5 mm in size, are widespread environmental pollutants that primarily result from the degradation of plastics and the release of products commonly used in daily life. As global plastic production continues to increase, the accumulation of MPs in ecosystems has raised significant concerns. These pollutants not only threaten environmental systems but also pose risks to human health, particularly by disrupting the relationship between humans and their gut microbiota. Research suggests that MPs could alter gut microbiota composition and function, potentially impacting microbial metabolic processes. To investigate this, three bacterial strains-Escherichia coli MG1655, Nissle 1917, and Lactobacillus rhamnosus-were exposed in vitro to varying concentrations (0-500 μg/mL) of 1 μm polystyrene MPs under controlled anaerobic conditions. The findings showed that MP exposure inhibited bacterial growth in a concentration-dependent manner. Metabolomic analysis, using LC-MS, identified significant changes in critical metabolic pathways, such as sulfur metabolism, amino sugar metabolism, and nucleotide sugar metabolism. In vivo analysis using gut microbiota from C57BL/6 mice further revealed significant shifts in microbial communities, with an increase in Lactobacillus and a decrease in Erysipelatoclostridium in MP-exposed groups. Metabolomics also revealed alterations in tryptophan metabolism and energy pathways. These results highlight MPs' potential to disrupt gut microbiota through metabolic changes, offering insights into their possible health impacts.

English

ISBN: 9798314876404Subjects--Topical Terms:

517777
Nutrition.
Subjects--Index Terms:

Microplastics

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /
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520 $a Microplastics (MPs), typically less than 5 mm in size, are widespread environmental pollutants that primarily result from the degradation of plastics and the release of products commonly used in daily life. As global plastic production continues to increase, the accumulation of MPs in ecosystems has raised significant concerns. These pollutants not only threaten environmental systems but also pose risks to human health, particularly by disrupting the relationship between humans and their gut microbiota. Research suggests that MPs could alter gut microbiota composition and function, potentially impacting microbial metabolic processes. To investigate this, three bacterial strains-Escherichia coli MG1655, Nissle 1917, and Lactobacillus rhamnosus-were exposed in vitro to varying concentrations (0-500 μg/mL) of 1 μm polystyrene MPs under controlled anaerobic conditions. The findings showed that MP exposure inhibited bacterial growth in a concentration-dependent manner. Metabolomic analysis, using LC-MS, identified significant changes in critical metabolic pathways, such as sulfur metabolism, amino sugar metabolism, and nucleotide sugar metabolism. In vivo analysis using gut microbiota from C57BL/6 mice further revealed significant shifts in microbial communities, with an increase in Lactobacillus and a decrease in Erysipelatoclostridium in MP-exposed groups. Metabolomics also revealed alterations in tryptophan metabolism and energy pathways. These results highlight MPs' potential to disrupt gut microbiota through metabolic changes, offering insights into their possible health impacts.
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650 4 $a Microbiology. $3 536250
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653 $a Gut microbiota
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