東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Assessment of Salivary Flow Patterns...

Alsunni, Mouna Abdulshaheed,

Linked to FindBook

Google Book

Amazon

博客來

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) // Mouna Abdulshaheed Alsunni.
Author:	Alsunni, Mouna Abdulshaheed,
Description:	1 electronic resource (55 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-05.
Contained By:	Masters Abstracts International86-05.
Subject:	Dentistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31633794
ISBN:	9798342744713

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /
Alsunni, Mouna Abdulshaheed,

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /Mouna Abdulshaheed Alsunni. - 1 electronic resource (55 pages)

Source: Masters Abstracts International, Volume: 86-05.

Aim and Hypothesis: Salivary flow follows a circadian pattern and is influenced by clock genes, which also regulate Aquaporins (AQPs), water channels responsible for salivary flow regulation in salivary glands. A deficiency in AQP5 in mouse salivary glands disrupted this pattern. We hypothesized that patients with Sjogren's Disease (SjD) do not exhibit the same circadian salivary flow pattern as healthy controls. The study compared salivary flow patterns in healthy individuals and SjD patients. To do this, we assessed stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) patterns in SjD subjects compared with healthy controls.Methods: Thirteen subjects per group were required to achieve 80% power. SjD subjects met the ACR/EULAR2016 criteria. During the first visit, participants provided consent. They received instructions for saliva collection at home at two time points (5 AM and 10 AM) for unstimulated whole saliva (UWS, 5 minutes) and stimulated whole saliva (SWS, 2 minutes), with a third sample collected on-site at 3 PM. Friedman's test compared salivary flow within each group across time points, while the Mann-Whitney U test compared salivary flow between groups. Generalized linear mixed models assessed group-time point interactions. Significance was set at α=0.05.Results: The study analyzed 13 healthy controls (10 female, 3 male, mean age 48.9 ± 10.7 years) and 13 SjD subjects (all female, mean age 65.3 ± 8.4 years). In SjD subjects, SWS 0.84 ± 0.83 mL/min, 1.08 ± 1.13 mL/min, and 1.00 ± 1.12 mL/min (p = 0.037) respectively. UWS ranged from 0.17 ± 0.21 mL/min at 5 AM to 0.24 ± 0.22 mL/min at 3 PM (p=0.46). No significant differences in control SWS; p = 0.527, with respective means of 2.80 ± 1.41 mL/min, 3.25 ± 1.81 mL/min, and 2.70 ± 1.42 mL/min. similar results were found in UWS: 1.03 ± 1.24 mL/min at 5 AM, 1.16 ± 1.34 mL/min at 10 AM, and 1.07 ± 1.29 mL/min at 3 PM (p = 0.527). SjD subjectsivhad significantly lower UWS and SWS rates than healthy controls (p0.05).Conclusion: The data do not support the hypothesis that SjD subjects have an altered salivary flow pattern compared to healthy controls. Neither SWS nor UWS exhibited a clear circadian pattern in healthy individuals, suggesting a need for further research into circadian influences on salivary flow in the healthy population.

English

ISBN: 9798342744713Subjects--Topical Terms:

828971
Dentistry.
Subjects--Index Terms:

Circadian pattern

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /
LDR:03800nmm a22004453i 4500 001 2437538
005 20251124054801.5
006 m o d
007 cr|nu||||||||
008 261011s2024 miu||||||m |||||||eng d
020 $a 9798342744713
035 $a (MiAaPQD)AAI31633794
035 $a AAI31633794
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Alsunni, Mouna Abdulshaheed, $e author. $3 3828556
245 1 0 $a Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) / $c Mouna Abdulshaheed Alsunni.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (55 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Masters Abstracts International, Volume: 86-05.
500 $a Advisors: Sankar, Vidya Committee members: Singh, Mabi; Finkelman, Matthew; Papas, Athena S.
502 $b M.S. $c Tufts University School of Dental Medicine $d 2024.
520 $a Aim and Hypothesis: Salivary flow follows a circadian pattern and is influenced by clock genes, which also regulate Aquaporins (AQPs), water channels responsible for salivary flow regulation in salivary glands. A deficiency in AQP5 in mouse salivary glands disrupted this pattern. We hypothesized that patients with Sjogren's Disease (SjD) do not exhibit the same circadian salivary flow pattern as healthy controls. The study compared salivary flow patterns in healthy individuals and SjD patients. To do this, we assessed stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) patterns in SjD subjects compared with healthy controls.Methods: Thirteen subjects per group were required to achieve 80% power. SjD subjects met the ACR/EULAR2016 criteria. During the first visit, participants provided consent. They received instructions for saliva collection at home at two time points (5 AM and 10 AM) for unstimulated whole saliva (UWS, 5 minutes) and stimulated whole saliva (SWS, 2 minutes), with a third sample collected on-site at 3 PM. Friedman's test compared salivary flow within each group across time points, while the Mann-Whitney U test compared salivary flow between groups. Generalized linear mixed models assessed group-time point interactions. Significance was set at α=0.05.Results: The study analyzed 13 healthy controls (10 female, 3 male, mean age 48.9 ± 10.7 years) and 13 SjD subjects (all female, mean age 65.3 ± 8.4 years). In SjD subjects, SWS 0.84 ± 0.83 mL/min, 1.08 ± 1.13 mL/min, and 1.00 ± 1.12 mL/min (p = 0.037) respectively. UWS ranged from 0.17 ± 0.21 mL/min at 5 AM to 0.24 ± 0.22 mL/min at 3 PM (p=0.46). No significant differences in control SWS; p = 0.527, with respective means of 2.80 ± 1.41 mL/min, 3.25 ± 1.81 mL/min, and 2.70 ± 1.42 mL/min. similar results were found in UWS: 1.03 ± 1.24 mL/min at 5 AM, 1.16 ± 1.34 mL/min at 10 AM, and 1.07 ± 1.29 mL/min at 3 PM (p = 0.527). SjD subjectsivhad significantly lower UWS and SWS rates than healthy controls (p0.05).Conclusion: The data do not support the hypothesis that SjD subjects have an altered salivary flow pattern compared to healthy controls. Neither SWS nor UWS exhibited a clear circadian pattern in healthy individuals, suggesting a need for further research into circadian influences on salivary flow in the healthy population.
546 $a English
590 $a School code: 1547
650 4 $a Dentistry. $3 828971
650 4 $a Health sciences. $3 3168359
650 4 $a Physiology. $3 518431
653 $a Circadian pattern
653 $a Circadian rhythm
653 $a Diurnal
653 $a Saliva
653 $a Salivary flow
653 $a Sjogren's disease
690 $a 0567
690 $a 0566
690 $a 0719
710 2 $a Tufts University School of Dental Medicine. $b Other. $e degree granting institution. $3 3828557
720 1 $a Sankar, Vidya $e degree supervisor.
773 0 $t Masters Abstracts International $g 86-05.
790 $a 1547
791 $a M.S.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31633794