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Molecular Basis of Plasticity of Por...

Rexhepaj, Megi,

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Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection // Megi Rexhepaj.
Author:	Rexhepaj, Megi,
Description:	1 electronic resource (85 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
Contained By:	Dissertations Abstracts International86-03B.
Subject:	Biochemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31557634
ISBN:	9798384098867

Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /
Rexhepaj, Megi,

Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /Megi Rexhepaj. - 1 electronic resource (85 pages)

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

Porcine deltacoronavirus (PDCoV) is an enteric pathogen that infects a broad range of mammal and avian species. Viral entry is achieved through the transmembrane spike (S) glycoprotein, specifically the receptor binding domain (RBD), binding to host receptor aminopeptidase N (APN). The S glycoprotein plays a key role in modulating host and tissue tropism, zoonotic transmission, and pathogenesis. The mechanism by which the S glycoprotein binds to a broad range of host receptors is not understood. Given that the S glycoprotein is the main target of antibodies and that neutralizing antibody titers are a correlate of protection against coronaviruses, the development of vaccines and therapeutics focuses intensively on this glycoprotein target. This research describes the molecular basis of binding of the S glycoprotein to host receptors and identifies the neutralizing epitopes on the S glycoproteins providing the first line of protection for a possible future PDCoV epidemic.

English

ISBN: 9798384098867Subjects--Topical Terms:

518028
Biochemistry.
Subjects--Index Terms:

Porcine deltacoronavirus

Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /
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020 $a 9798384098867
035 $a (MiAaPQD)AAI31557634
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100 1 $a Rexhepaj, Megi, $e author. $3 3828546
245 1 0 $a Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection / $c Megi Rexhepaj.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (85 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
500 $a Advisors: Kollman, Justin M. Committee members: Hoppins, Suzanne; Hurley, James B.; Voorhis, Wesley van C.; Wills, Andrea.
502 $b Ph.D. $c University of Washington $d 2024.
520 $a Porcine deltacoronavirus (PDCoV) is an enteric pathogen that infects a broad range of mammal and avian species. Viral entry is achieved through the transmembrane spike (S) glycoprotein, specifically the receptor binding domain (RBD), binding to host receptor aminopeptidase N (APN). The S glycoprotein plays a key role in modulating host and tissue tropism, zoonotic transmission, and pathogenesis. The mechanism by which the S glycoprotein binds to a broad range of host receptors is not understood. Given that the S glycoprotein is the main target of antibodies and that neutralizing antibody titers are a correlate of protection against coronaviruses, the development of vaccines and therapeutics focuses intensively on this glycoprotein target. This research describes the molecular basis of binding of the S glycoprotein to host receptors and identifies the neutralizing epitopes on the S glycoproteins providing the first line of protection for a possible future PDCoV epidemic.
546 $a English
590 $a School code: 0250
650 4 $a Biochemistry. $3 518028
650 4 $a Molecular biology. $3 517296
650 4 $a Immunology. $3 611031
650 4 $a Virology. $3 642304
653 $a Porcine deltacoronavirus
653 $a Receptor binding domain
653 $a Glycoprotein
653 $a Aminopeptidase N
653 $a Monoclonal antibodies
690 $a 0487
690 $a 0720
690 $a 0982
690 $a 0307
710 2 $a University of Washington. $b Biochemistry. $e degree granting institution. $3 3828547
720 1 $a Kollman, Justin M. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-03B.
790 $a 0250
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31557634