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Identification of Therapeutics for P...

Morales Vasquez, Desarey,

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Identification of Therapeutics for Public Health Emergent Viruses: Zika Virus and Severe Acute Respiratory Syndrome Coronavirus 2 /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Identification of Therapeutics for Public Health Emergent Viruses: Zika Virus and Severe Acute Respiratory Syndrome Coronavirus 2 // Desarey Morales Vasquez.
Author:	Morales Vasquez, Desarey,
Description:	1 electronic resource (183 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
Contained By:	Dissertations Abstracts International86-02B.
Subject:	Virology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31299908
ISBN:	9798383683750

Identification of Therapeutics for Public Health Emergent Viruses: Zika Virus and Severe Acute Respiratory Syndrome Coronavirus 2 /
Morales Vasquez, Desarey,

Identification of Therapeutics for Public Health Emergent Viruses: Zika Virus and Severe Acute Respiratory Syndrome Coronavirus 2 /Desarey Morales Vasquez. - 1 electronic resource (183 pages)

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

The emergence of viral outbreaks has posed a great human threat and severely affected communities, public health infrastructures, and economies globally. In the last 20 years, the world has been hit by several and significant viral diseases, including the 2003 outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV), the 2009 outbreak of H1N1 influenza virus, the 2012 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV), the 2015 outbreak of Zika virus (ZIKV), the 2020 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the 2022 outbreak of monkeypox virus (MPOX). These outbreaks caused severe damage overall to the countries affected but more importantly, they also demonstrated how unprepared the world is for these emerging pathogens. Despite efforts, the prophylactics and therapeutics developed to combat these viruses were not effective and/or long lasting, urging to identify better approaches. In this dissertation, the goal was to utilize drug repurposing, e.g. drugs already approved or studied for the treatment of a new disease, as an approach to identify broad-spectrum antivirals that could be used against emerging viral infections. This is possible due to the target of the compound being a host factor that is required by different viruses to replicate. While identifying therapeutics against ZIKV, SARS-CoV-2 emerged so we applied our expertise in drug discovery to identify therapeutics against SARS-CoV-2 . Utilizing compounds from ReFRAME and NPC libraries, we were able to identify inhibitors against ZIKV and SARS-CoV-2.

English

ISBN: 9798383683750Subjects--Topical Terms:

642304
Virology.
Subjects--Index Terms:

Public health emergence

Identification of Therapeutics for Public Health Emergent Viruses: Zika Virus and Severe Acute Respiratory Syndrome Coronavirus 2 /
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520 $a The emergence of viral outbreaks has posed a great human threat and severely affected communities, public health infrastructures, and economies globally. In the last 20 years, the world has been hit by several and significant viral diseases, including the 2003 outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV), the 2009 outbreak of H1N1 influenza virus, the 2012 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV), the 2015 outbreak of Zika virus (ZIKV), the 2020 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the 2022 outbreak of monkeypox virus (MPOX). These outbreaks caused severe damage overall to the countries affected but more importantly, they also demonstrated how unprepared the world is for these emerging pathogens. Despite efforts, the prophylactics and therapeutics developed to combat these viruses were not effective and/or long lasting, urging to identify better approaches. In this dissertation, the goal was to utilize drug repurposing, e.g. drugs already approved or studied for the treatment of a new disease, as an approach to identify broad-spectrum antivirals that could be used against emerging viral infections. This is possible due to the target of the compound being a host factor that is required by different viruses to replicate. While identifying therapeutics against ZIKV, SARS-CoV-2 emerged so we applied our expertise in drug discovery to identify therapeutics against SARS-CoV-2 . Utilizing compounds from ReFRAME and NPC libraries, we were able to identify inhibitors against ZIKV and SARS-CoV-2.
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650 4 $a Public health. $3 534748
650 4 $a Pharmacology. $3 634543
650 4 $a Immunology. $3 611031
653 $a Public health emergence
653 $a Repurposing
653 $a Severe acute respiratory syndrome coronavirus 2
653 $a Screening
653 $a Therapeutics
653 $a Zika virus
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690 $a 0419
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710 2 $a The University of Texas Health Science Center at San Antonio. $b Molecular Medicine. $e degree granting institution. $3 3828525
720 1 $a Martinez-Sobrido, Luis $e degree supervisor.
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