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Dietary Animal Fat Disrupts Gut Micr...

Millick, Danielle D.,

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Dietary Animal Fat Disrupts Gut Microbiota and Aggravates Graft-Versus-Host Disease Following Hematopoietic Stem Cell Transfer /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dietary Animal Fat Disrupts Gut Microbiota and Aggravates Graft-Versus-Host Disease Following Hematopoietic Stem Cell Transfer // Danielle D Millick.
Author:	Millick, Danielle D.,
Description:	1 electronic resource (114 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
Contained By:	Dissertations Abstracts International85-11B.
Subject:	Immunology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31143273
ISBN:	9798382759739

Dietary Animal Fat Disrupts Gut Microbiota and Aggravates Graft-Versus-Host Disease Following Hematopoietic Stem Cell Transfer /
Millick, Danielle D.,

Dietary Animal Fat Disrupts Gut Microbiota and Aggravates Graft-Versus-Host Disease Following Hematopoietic Stem Cell Transfer /Danielle D Millick. - 1 electronic resource (114 pages)

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

The gut microbiome and dietary regimen are two modifiable variables that have been widely investigated as factors that can impact Graft-versus-host disease (GVHD) following allogeneic bone marrow transplant. The rise in fat content has been linked to a reduction in gut microbiome diversity and an aggravation of GVHD. However, the impact of the quality of dietary fat on both the gut microbiota and GVHD outcome remains elusive. Here, we developed two rodent diets with moderate fat, ensuring equivalent macronutrient composition while varying only in fat type-animal-derived versus plant-derived fat. We found that mice fed the animal fat diet (AFD) compared to a plant fed diet (PFD) exhibited worse outcomes in a model of chronic GVHD. The mice fed an AFD had an elevated serum cytokine response, more severe skin inflammation and more intestinal immune dysregulation, compared to mice fed a PFD. While both diets caused reductions of gut microbial diversity, the diets induced discrete gut microbial structures. Further, we identified two guilds consisting of 18 amplicon sequence variants (ASVs) that distinguished between AFD and PFD-fed mice and may contribute to disease severity in AFD group. Our data show that even short-term feeding of diets that are equal in macronutrient content but different in fat source can promote different gut microbiomes, alter intestinal homeostasis, and drive differential Scl-cGVHD outcomes.

English

ISBN: 9798382759739Subjects--Topical Terms:

611031
Immunology.
Subjects--Index Terms:

Gut microbiome

Dietary Animal Fat Disrupts Gut Microbiota and Aggravates Graft-Versus-Host Disease Following Hematopoietic Stem Cell Transfer /
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520 $a The gut microbiome and dietary regimen are two modifiable variables that have been widely investigated as factors that can impact Graft-versus-host disease (GVHD) following allogeneic bone marrow transplant. The rise in fat content has been linked to a reduction in gut microbiome diversity and an aggravation of GVHD. However, the impact of the quality of dietary fat on both the gut microbiota and GVHD outcome remains elusive. Here, we developed two rodent diets with moderate fat, ensuring equivalent macronutrient composition while varying only in fat type-animal-derived versus plant-derived fat. We found that mice fed the animal fat diet (AFD) compared to a plant fed diet (PFD) exhibited worse outcomes in a model of chronic GVHD. The mice fed an AFD had an elevated serum cytokine response, more severe skin inflammation and more intestinal immune dysregulation, compared to mice fed a PFD. While both diets caused reductions of gut microbial diversity, the diets induced discrete gut microbial structures. Further, we identified two guilds consisting of 18 amplicon sequence variants (ASVs) that distinguished between AFD and PFD-fed mice and may contribute to disease severity in AFD group. Our data show that even short-term feeding of diets that are equal in macronutrient content but different in fat source can promote different gut microbiomes, alter intestinal homeostasis, and drive differential Scl-cGVHD outcomes.
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