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Properties of Coronavirus Spike Prot...

Addetia, Amin,

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Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them // Amin Addetia.
Author:	Addetia, Amin,
Description:	1 electronic resource (263 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-10, Section: B.
Contained By:	Dissertations Abstracts International85-10B.
Subject:	Biochemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30988463
ISBN:	9798382211145

Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /
Addetia, Amin,

Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /Amin Addetia. - 1 electronic resource (263 pages)

Source: Dissertations Abstracts International, Volume: 85-10, Section: B.

Coronaviruses have a propensity to spillover from zoonotic reservoirs and cause significant morbidity and mortality in the human population. Three coronaviruses emerged and caused significant human outbreaks in recent history: severe acute respiratory syndrome coronavirus (SARS-CoV-1) in 2003, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019. The coronavirus spike protein facilitates viral entry into target cells by engaging the host receptors and fusing the viral and host membrane together. As the primary determinant of viral entry into target cells, the coronavirus spike protein is the target of most vaccines and therapeutics. Antibodies induced by prior infection and vaccination and therapeutics may select for spike protein mutations that evade these antibodies without disrupting the spike protein's ability to engage the host receptor and mediate membrane fusion. In the following dissertation, I detail a unique mechanism of antibody evasion induced by a mutation in the receptor binding domain of the SARS-CoV-2 spike protein. I additionally describe the impact of spike protein mutations observed in the SARS-CoV-2 Omicron variants on receptor engagement, fusogenicity, and evasion from infection- and vaccine-elicited antibodies. I further examine how updated SARS-CoV-2 vaccine formulations shape the humoral immune response. Finally, I detail the contribution of spike protein domains and epitopes to the neutralizing activity of convalescent plasma collected from individuals infected with MERS-CoV. Collectively, my work is informing the development of the next generation of coronavirus vaccines and therapeutics.

English

ISBN: 9798382211145Subjects--Topical Terms:

518028
Biochemistry.
Subjects--Index Terms:

Coronaviruses

Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /
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245 1 0 $a Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them / $c Amin Addetia.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (263 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 85-10, Section: B.
500 $a Advisors: Veesler, David J. Committee members: Bloom, Jesse D.; Greninger, Alex.
502 $b Ph.D. $c University of Washington $d 2024.
520 $a Coronaviruses have a propensity to spillover from zoonotic reservoirs and cause significant morbidity and mortality in the human population. Three coronaviruses emerged and caused significant human outbreaks in recent history: severe acute respiratory syndrome coronavirus (SARS-CoV-1) in 2003, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019. The coronavirus spike protein facilitates viral entry into target cells by engaging the host receptors and fusing the viral and host membrane together. As the primary determinant of viral entry into target cells, the coronavirus spike protein is the target of most vaccines and therapeutics. Antibodies induced by prior infection and vaccination and therapeutics may select for spike protein mutations that evade these antibodies without disrupting the spike protein's ability to engage the host receptor and mediate membrane fusion. In the following dissertation, I detail a unique mechanism of antibody evasion induced by a mutation in the receptor binding domain of the SARS-CoV-2 spike protein. I additionally describe the impact of spike protein mutations observed in the SARS-CoV-2 Omicron variants on receptor engagement, fusogenicity, and evasion from infection- and vaccine-elicited antibodies. I further examine how updated SARS-CoV-2 vaccine formulations shape the humoral immune response. Finally, I detail the contribution of spike protein domains and epitopes to the neutralizing activity of convalescent plasma collected from individuals infected with MERS-CoV. Collectively, my work is informing the development of the next generation of coronavirus vaccines and therapeutics.
546 $a English
590 $a School code: 0250
650 4 $a Biochemistry. $3 518028
650 4 $a Immunology. $3 611031
650 4 $a Virology. $3 642304
653 $a Coronaviruses
653 $a Respiratory syndrome
653 $a Immune response
653 $a Vaccines
690 $a 0487
690 $a 0982
690 $a 0720
710 2 $a University of Washington. $b Molecular and Cellular Biology. $e degree granting institution. $3 3827251
720 1 $a Veesler, David J. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-10B.
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791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30988463