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DNA methylation as an epigenetic inf...

Kendall, Lindsay Rosselet,

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DNA methylation as an epigenetic information system in marine invertebrates /

Record Type:	Electronic resources : Monograph/item
Title/Author:	DNA methylation as an epigenetic information system in marine invertebrates // Lindsay Rosselet Kendall.
Author:	Kendall, Lindsay Rosselet,
Description:	1 electronic resource (149 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 70-09, Section: B.
Contained By:	Dissertations Abstracts International70-09B.
Subject:	Genetics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3344038
ISBN:	9781109784008

DNA methylation as an epigenetic information system in marine invertebrates /
Kendall, Lindsay Rosselet,

DNA methylation as an epigenetic information system in marine invertebrates /Lindsay Rosselet Kendall. - 1 electronic resource (149 pages)

Source: Dissertations Abstracts International, Volume: 70-09, Section: B.

The field of epigenetics, defined as the study of the information system which lies on top of DNA, has been rapidly growing over the past decade. Recent findings have shed light on the mechanisms and functions of mammalian epigenetic information systems, including histone modifications, small RNAs, and DNA methylation. The functions and mechanisms of non-mammalian epigenetic information systems have also been investigated, although overall much less is known about invertebrate than mammalian epigenetics. An ultimate role for DNA methylation in invertebrates is yet to be agreed upon, as several invertebrate species seem to be lacking DNA methylation entirely. If DNA methylation is ubiquitously present in all invertebrate phyla, it would provide evidence that the ultimate role of DNA methylation in invertebrates is necessary to invertebrate genome function and not a vestigial phenomenon. The poecilogonous polychaete Streblospio benedicti has dual developmental modes, with individual worms developing either as planktotrophs or lecithotrophs. The mechanism controlling the developmental "choice" between planktotrophy and lecithotrophy is yet unknown, although it has been found that developmental morphs do not have different mitochondrial genetic sequences. In light of recent advances in understanding epigenetics in mammalian systems, it seems plausible that the developmental morphotype "choice" may be governed by an epigenetic system. In mammalian systems, it has been demonstrated that the environment can directly change epigenetic signatures, however such a phenomenon has not been documented in an invertebrate system. Endogenous epigenetic signatures of the polychaete S. benedicti sort by geographic clade, indicating that the environment may directly impact the epigenome of this marine polychaete. This study investigates the distribution of an epigenetic information system, DNA methylation, across the invertebrate phyla, as well as investigating further the DNA methylation system in the poecilogonous polychaete, Streblospio benedicti.

English

ISBN: 9781109784008Subjects--Topical Terms:

530508
Genetics.
Subjects--Index Terms:

DNA methylation

DNA methylation as an epigenetic information system in marine invertebrates /
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100 1 $a Kendall, Lindsay Rosselet, $e author. $3 3828421
245 1 0 $a DNA methylation as an epigenetic information system in marine invertebrates / $c Lindsay Rosselet Kendall.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2009
300 $a 1 electronic resource (149 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 70-09, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisors: Marsh, Adam G. Committee members: Burnside, Joan; Gaffney, Patrick; Targett, Nancy.
502 $b Ph.D. $c University of Delaware $d 2009.
520 $a The field of epigenetics, defined as the study of the information system which lies on top of DNA, has been rapidly growing over the past decade. Recent findings have shed light on the mechanisms and functions of mammalian epigenetic information systems, including histone modifications, small RNAs, and DNA methylation. The functions and mechanisms of non-mammalian epigenetic information systems have also been investigated, although overall much less is known about invertebrate than mammalian epigenetics. An ultimate role for DNA methylation in invertebrates is yet to be agreed upon, as several invertebrate species seem to be lacking DNA methylation entirely. If DNA methylation is ubiquitously present in all invertebrate phyla, it would provide evidence that the ultimate role of DNA methylation in invertebrates is necessary to invertebrate genome function and not a vestigial phenomenon. The poecilogonous polychaete Streblospio benedicti has dual developmental modes, with individual worms developing either as planktotrophs or lecithotrophs. The mechanism controlling the developmental "choice" between planktotrophy and lecithotrophy is yet unknown, although it has been found that developmental morphs do not have different mitochondrial genetic sequences. In light of recent advances in understanding epigenetics in mammalian systems, it seems plausible that the developmental morphotype "choice" may be governed by an epigenetic system. In mammalian systems, it has been demonstrated that the environment can directly change epigenetic signatures, however such a phenomenon has not been documented in an invertebrate system. Endogenous epigenetic signatures of the polychaete S. benedicti sort by geographic clade, indicating that the environment may directly impact the epigenome of this marine polychaete. This study investigates the distribution of an epigenetic information system, DNA methylation, across the invertebrate phyla, as well as investigating further the DNA methylation system in the poecilogonous polychaete, Streblospio benedicti.
546 $a English
590 $a School code: 0060
650 4 $a Genetics. $3 530508
650 4 $a Biological oceanography. $3 2122748
653 $a DNA methylation
653 $a Epigenetics
653 $a HPLC
653 $a Invertebrates
653 $a Methylation
653 $a Streblospio
690 $a 0369
690 $a 0416
710 2 $a University of Delaware. $b Marine Studies. $e degree granting institution. $3 3816843
720 1 $a Marsh, Adam G. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 70-09B.
790 $a 0060
791 $a Ph.D.
792 $a 2009
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