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The Transgenerational Effects of a D...

De Serrano, Alexandra Rae,

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The Transgenerational Effects of a Dpaminergic Drug on the Behaviour and Morphology of the Trinidadian Guppy (Poecilia Reticulata) /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Transgenerational Effects of a Dpaminergic Drug on the Behaviour and Morphology of the Trinidadian Guppy (Poecilia Reticulata) // Alexandra Rae De Serrano.
Author:	De Serrano, Alexandra Rae,
Description:	1 electronic resource (270 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-09, Section: B.
Contained By:	Dissertations Abstracts International83-09B.
Subject:	Evolution & development. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28773502
ISBN:	9798209903758

The Transgenerational Effects of a Dpaminergic Drug on the Behaviour and Morphology of the Trinidadian Guppy (Poecilia Reticulata) /
De Serrano, Alexandra Rae,

The Transgenerational Effects of a Dpaminergic Drug on the Behaviour and Morphology of the Trinidadian Guppy (Poecilia Reticulata) /Alexandra Rae De Serrano. - 1 electronic resource (270 pages)

Source: Dissertations Abstracts International, Volume: 83-09, Section: B.

Maternal effects are ubiquitous, but paternal effects, the nongenetic influence of fathers on their offspring, were traditionally thought to be limited to animal species with paternal care/investment, however, there is now evidence that fathers can influence their offspring via nongenetic factors (interactions with females, modifications to sperm/ejaculate). There is also limited evidence that both maternal and paternal effects can span several generations, i.e. they can be transgenerational, but it is not yet clear if this phenomenon is generalizable across taxa. For my dissertation, I asked if there were parental and transgenerational effects of a dopaminergic drug (the psychostimulant methylphenidate hydrochloride (MPH), known as Ritalin or Concerta) on Trinidadian guppies. I selected MPH because it is highly prescribed for the treatment of Attention-deficit/hyperactivity disorder and, given its pharmacology, it was predicted that it could cause transgenerational effects; despite this, the paternal and transgenerational effects of MPH were unknown. I found that MPH treatment had significant effects on the behaviour of first-generation males, and the morphology of first-generation males and females. I also found that some of these effects persisted across generations. First, MPH treatment directly affected male mating behaviours, with downstream effects on the behaviour of offspring; there was evidence that paternal effects were mediated by females for the offspring of control fathers, but, not for the offspring of MPH-treated fathers, suggesting nongenetic modifications to sperm as a potential mechanism. I also describe transgenerational effects of MPH in later generations and observed that behavioural effects of MPH were transmitted through the paternal, but not maternal, line to male and female great-grandoffspring-a generation that was not directly exposed to MPH. For morphological traits (body size and male colouration), I observed that both maternal and paternal treatment affected some offspring and grandoffspring morphological traits, highlighting the importance of exploring maternal and paternal effects in tandem. Taken together, this research is the first to demonstrate that MPH can cause transgenerational effects, which highlights the need to consider parental and transgenerational effects in studies of human health and the responses of natural populations to anthropogenic effects (e.g. exposure to pollutants, climate change).

English

ISBN: 9798209903758Subjects--Topical Terms:

3172418
Evolution & development.
Subjects--Index Terms:

Dopamine

The Transgenerational Effects of a Dpaminergic Drug on the Behaviour and Morphology of the Trinidadian Guppy (Poecilia Reticulata) /
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520 $a Maternal effects are ubiquitous, but paternal effects, the nongenetic influence of fathers on their offspring, were traditionally thought to be limited to animal species with paternal care/investment, however, there is now evidence that fathers can influence their offspring via nongenetic factors (interactions with females, modifications to sperm/ejaculate). There is also limited evidence that both maternal and paternal effects can span several generations, i.e. they can be transgenerational, but it is not yet clear if this phenomenon is generalizable across taxa. For my dissertation, I asked if there were parental and transgenerational effects of a dopaminergic drug (the psychostimulant methylphenidate hydrochloride (MPH), known as Ritalin or Concerta) on Trinidadian guppies. I selected MPH because it is highly prescribed for the treatment of Attention-deficit/hyperactivity disorder and, given its pharmacology, it was predicted that it could cause transgenerational effects; despite this, the paternal and transgenerational effects of MPH were unknown. I found that MPH treatment had significant effects on the behaviour of first-generation males, and the morphology of first-generation males and females. I also found that some of these effects persisted across generations. First, MPH treatment directly affected male mating behaviours, with downstream effects on the behaviour of offspring; there was evidence that paternal effects were mediated by females for the offspring of control fathers, but, not for the offspring of MPH-treated fathers, suggesting nongenetic modifications to sperm as a potential mechanism. I also describe transgenerational effects of MPH in later generations and observed that behavioural effects of MPH were transmitted through the paternal, but not maternal, line to male and female great-grandoffspring-a generation that was not directly exposed to MPH. For morphological traits (body size and male colouration), I observed that both maternal and paternal treatment affected some offspring and grandoffspring morphological traits, highlighting the importance of exploring maternal and paternal effects in tandem. Taken together, this research is the first to demonstrate that MPH can cause transgenerational effects, which highlights the need to consider parental and transgenerational effects in studies of human health and the responses of natural populations to anthropogenic effects (e.g. exposure to pollutants, climate change).
546 $a English
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650 4 $a Evolution & development. $3 3172418
650 4 $a Ecology. $3 516476
650 4 $a Behavioral sciences. $3 529833
653 $a Dopamine
653 $a Epigenetics
653 $a Trinidadian guppies
653 $a Paternal effects
653 $a Transgenerational effects
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710 2 $a University of Toronto (Canada). $b Ecology and Evolutionary Biology. $e degree granting institution. $3 3815388
720 1 $a Rodd, Helen $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 83-09B.
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791 $a Ph.D.
792 $a 2022
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28773502