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Bone Functional Adaptation: Life His...

Gildee, Cristina,

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Bone Functional Adaptation: Life History Constraints and Implications for Aging Research /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Bone Functional Adaptation: Life History Constraints and Implications for Aging Research // Cristina Gildee.
Author:	Gildee, Cristina,
Description:	1 electronic resource (225 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 87-01, Section: B.
Contained By:	Dissertations Abstracts International87-01B.
Subject:	Physical anthropology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32116263
ISBN:	9798288823244

Bone Functional Adaptation: Life History Constraints and Implications for Aging Research /
Gildee, Cristina,

Bone Functional Adaptation: Life History Constraints and Implications for Aging Research /Cristina Gildee. - 1 electronic resource (225 pages)

Source: Dissertations Abstracts International, Volume: 87-01, Section: B.

This dissertation examines skeletal adaptation across human life history, emphasizing how reproductive investment and aging influence bone mineral density (BMD), a crucial determinant of bone health and resilience. Specifically, it investigates how parity, habitual mechanical loading, and cellular aging-proxied by leukocyte telomere length (TL)--interact to shape regional variation in BMD. The first study analyzed associations between parity and regional BMD using anthropometric, dual-energy X-ray absorptiometry, health biomarker, and questionnaire data from the National Health and Nutrition Examination Survey (NHANES cohorts 2007-2018). Results showed that higher parity was linked with lower BMD, particularly in metabolically active skeletal sites such as the lumbar spine, highlighting the metabolic demands of reproduction on skeletal maintenance. The second study assessed whether habitual mechanical loading could buffer age-related BMD loss by comparing weight-bearing and non-weight-bearing skeletal regions. Findings demonstrated similar age-related declines between weight-bearing and non-weight-bearing regions, though gendered differences emerged; women experienced steeper declines in non-weight-bearing regions compared to weight-bearing regions, indicating that loading alone is insufficient to protect against aging-related skeletal deterioration. The third study investigated whether telomere length, a biomarker of cellular aging, is associated with regional BMD variation and parity (NHANES 1999-2002). Results showed that shorter TL correlated with lower BMD selectively in women but did not mediate the association between parity and BMD. Together, these findings demonstrate that reproductive history and cellular aging independently influence skeletal health across the lifespan. This dissertation emphasizes the complexity of skeletal aging and the importance of integrating life history theory, biomechanical analysis, and cellular biology to understand bone health in evolutionary, clinical, and public health contexts. .

English

ISBN: 9798288823244Subjects--Topical Terms:

518358
Physical anthropology.
Subjects--Index Terms:

Biological anthropology

Bone Functional Adaptation: Life History Constraints and Implications for Aging Research /
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245 1 0 $a Bone Functional Adaptation: Life History Constraints and Implications for Aging Research / $c Cristina Gildee.
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500 $a Source: Dissertations Abstracts International, Volume: 87-01, Section: B.
500 $a Advisors: Kramer, Patricia Ann Committee members: Martin, Melanie; Eisenberg, Dan T. A.
502 $b Ph.D. $c University of Washington $d 2025.
520 $a This dissertation examines skeletal adaptation across human life history, emphasizing how reproductive investment and aging influence bone mineral density (BMD), a crucial determinant of bone health and resilience. Specifically, it investigates how parity, habitual mechanical loading, and cellular aging-proxied by leukocyte telomere length (TL)--interact to shape regional variation in BMD. The first study analyzed associations between parity and regional BMD using anthropometric, dual-energy X-ray absorptiometry, health biomarker, and questionnaire data from the National Health and Nutrition Examination Survey (NHANES cohorts 2007-2018). Results showed that higher parity was linked with lower BMD, particularly in metabolically active skeletal sites such as the lumbar spine, highlighting the metabolic demands of reproduction on skeletal maintenance. The second study assessed whether habitual mechanical loading could buffer age-related BMD loss by comparing weight-bearing and non-weight-bearing skeletal regions. Findings demonstrated similar age-related declines between weight-bearing and non-weight-bearing regions, though gendered differences emerged; women experienced steeper declines in non-weight-bearing regions compared to weight-bearing regions, indicating that loading alone is insufficient to protect against aging-related skeletal deterioration. The third study investigated whether telomere length, a biomarker of cellular aging, is associated with regional BMD variation and parity (NHANES 1999-2002). Results showed that shorter TL correlated with lower BMD selectively in women but did not mediate the association between parity and BMD. Together, these findings demonstrate that reproductive history and cellular aging independently influence skeletal health across the lifespan. This dissertation emphasizes the complexity of skeletal aging and the importance of integrating life history theory, biomechanical analysis, and cellular biology to understand bone health in evolutionary, clinical, and public health contexts. .
546 $a English
590 $a School code: 0250
650 4 $a Physical anthropology. $3 518358
650 4 $a Cellular biology. $3 3172791
650 4 $a Aging. $3 543123
653 $a Biological anthropology
653 $a Bone mineral density
653 $a Reproduction
690 $a 0327
690 $a 0379
690 $a 0493
710 2 $a University of Washington. $b Anthropology. $e degree granting institution. $3 3828212
720 1 $a Kramer, Patricia Ann $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 87-01B.
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791 $a Ph.D.
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