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Environmental Exposure to Metals in ...

Ogunesan, Oludesola,

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Environmental Exposure to Metals in Children and Their Effects on Autism Spectrum Disorder /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Environmental Exposure to Metals in Children and Their Effects on Autism Spectrum Disorder // Oludesola Ogunesan.
Author:	Ogunesan, Oludesola,
Description:	1 electronic resource (181 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-12, Section: A.
Contained By:	Dissertations Abstracts International86-12A.
Subject:	Environmental health. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31934934
ISBN:	9798315790822

Environmental Exposure to Metals in Children and Their Effects on Autism Spectrum Disorder /
Ogunesan, Oludesola,

Environmental Exposure to Metals in Children and Their Effects on Autism Spectrum Disorder /Oludesola Ogunesan. - 1 electronic resource (181 pages)

Source: Dissertations Abstracts International, Volume: 86-12, Section: A.

As scientific understanding of environmental determinants of health advances, growing attention has turned to the role of toxic metal exposures in exacerbating neurodevelopmental outcomes, particularly in vulnerable populations such as children with autism spectrum disorder (ASD). This dissertation investigates the intersection of environmental metal exposure, biomonitoring innovation, and social factors shaping ASD severity in Alabama. Using a multidisciplinary framework, four interrelated studies explore biological, environmental, and participatory dimensions of ASD research and public health. The first study evaluates the utility of Volumetric Absorptive Microsampling (VAMS) for measuring exposure to cadmium (Cd), chromium (Cr), lead (Pb), manganese (Mn), and mercury (Hg) in children diagnosed with ASD. VAMS offers a minimally invasive and accessible alternative to venous blood collection, especially beneficial for pediatric populations. However, technical challenges such as contamination and limited sample volume highlight the need for refinement before widespread adoption in environmental epidemiology. The second study investigates the correlation between census-tract-level airborne metal concentrations estimated via environmental screening tools and ASD severity across Alabama. Findings reveal that children residing in areas with elevated airborne metal pollution, particularly in industrialized zones, tend to exhibit more severe ASD symptoms, underscoring the spatial inequalities in exposure risk. The third study analyzes the association between blood metal concentrations and ASD severity, identifying significant positive correlations between cadmium and lead and increased symptom severity. These findings reinforce concerns about the neurotoxic potential of environmental metals and their disproportionate burden on children with developmental vulnerabilities. The fourth study assesses parental awareness and participation in environmental ASD research. It reveals notable gaps in environmental health literacy and highlights how previous research engagement influences communication preferences and study participation. Barriers such as mistrust, time constraints, and perceived lack of benefit reduce participation among caregivers, particularly in underserved communities. Together, these studies provide a comprehensive understanding of how environmental exposures, spatial disparities, and community engagement intersect to influence ASD outcomes in Alabama. They collectively underscore the urgent need for targeted public health interventions, refined exposure assessment techniques, and inclusive research practices.

English

ISBN: 9798315790822Subjects--Topical Terms:

543032
Environmental health.
Subjects--Index Terms:

Autism spectrum disorder

Environmental Exposure to Metals in Children and Their Effects on Autism Spectrum Disorder /
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520 $a As scientific understanding of environmental determinants of health advances, growing attention has turned to the role of toxic metal exposures in exacerbating neurodevelopmental outcomes, particularly in vulnerable populations such as children with autism spectrum disorder (ASD). This dissertation investigates the intersection of environmental metal exposure, biomonitoring innovation, and social factors shaping ASD severity in Alabama. Using a multidisciplinary framework, four interrelated studies explore biological, environmental, and participatory dimensions of ASD research and public health. The first study evaluates the utility of Volumetric Absorptive Microsampling (VAMS) for measuring exposure to cadmium (Cd), chromium (Cr), lead (Pb), manganese (Mn), and mercury (Hg) in children diagnosed with ASD. VAMS offers a minimally invasive and accessible alternative to venous blood collection, especially beneficial for pediatric populations. However, technical challenges such as contamination and limited sample volume highlight the need for refinement before widespread adoption in environmental epidemiology. The second study investigates the correlation between census-tract-level airborne metal concentrations estimated via environmental screening tools and ASD severity across Alabama. Findings reveal that children residing in areas with elevated airborne metal pollution, particularly in industrialized zones, tend to exhibit more severe ASD symptoms, underscoring the spatial inequalities in exposure risk. The third study analyzes the association between blood metal concentrations and ASD severity, identifying significant positive correlations between cadmium and lead and increased symptom severity. These findings reinforce concerns about the neurotoxic potential of environmental metals and their disproportionate burden on children with developmental vulnerabilities. The fourth study assesses parental awareness and participation in environmental ASD research. It reveals notable gaps in environmental health literacy and highlights how previous research engagement influences communication preferences and study participation. Barriers such as mistrust, time constraints, and perceived lack of benefit reduce participation among caregivers, particularly in underserved communities. Together, these studies provide a comprehensive understanding of how environmental exposures, spatial disparities, and community engagement intersect to influence ASD outcomes in Alabama. They collectively underscore the urgent need for targeted public health interventions, refined exposure assessment techniques, and inclusive research practices.
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650 4 $a Toxicology. $3 556884
650 4 $a Epidemiology. $3 568544
650 4 $a Pediatrics. $3 559143
650 4 $a Disability studies. $3 543687
653 $a Autism spectrum disorder
653 $a Environmental exposure
653 $a Metal biomarkers
653 $a Parental engagement
653 $a Spatial analysis
653 $a Volumetric absorptive microsampling
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