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Investigating the Impact of Gamma-Am...

Aggarwal, Dishant,

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Investigating the Impact of Gamma-Aminobutyric Acid (GABA) Producing Probiotics on Healthy Aging /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigating the Impact of Gamma-Aminobutyric Acid (GABA) Producing Probiotics on Healthy Aging // Dishant Aggarwal.
Author:	Aggarwal, Dishant,
Description:	1 electronic resource (99 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-10.
Contained By:	Masters Abstracts International86-10.
Subject:	Pharmaceutical sciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31932943
ISBN:	9798310350601

Investigating the Impact of Gamma-Aminobutyric Acid (GABA) Producing Probiotics on Healthy Aging /
Aggarwal, Dishant,

Investigating the Impact of Gamma-Aminobutyric Acid (GABA) Producing Probiotics on Healthy Aging /Dishant Aggarwal. - 1 electronic resource (99 pages)

Source: Masters Abstracts International, Volume: 86-10.

Aging is linked to reduced GABA production and gut microbiota changes, impacting metabolism and immunity. We hypothesize that a GABA-producing probiotic will enhance immune function and alter the metabolic profile of aging mice. This intervention may also improve intestinal barrier integrity and reduce inflammation, offering antiaging benefits. Declining gut lactic acid bacteria (LAB) and GABA levels may contribute to unhealthy aging and immune-related diseases. In our current study, we introduce the Lactococcus lactis strain IL1403 and Lactococcus lactis-P8s-GAD, a genetically engineered probiotic into the adult rats that increases the production of GABA in the gut and considered the subsequent impact on the microbial diversity through 16S rRNA sequencing, and developed proteomic and metabolic profiles in aging animals. We found significant differences in the body weight of animals up to 6 weeks of the study. However, we found a difference in the microbial diversity of the group treated with original bacterial strain IL1403 compared to other groups. Further we found little evidence of reduction in the ratio of firmicutes/bacteroidetes among the treatment group of animals, an indicator of oxidative stress among aged animals. In proteomic analysis, we able to express the number of proteins either upregulated or downregulated which play a crucial role in the pathophysiology of the different ailments and can target specific proteins for the diagnosis and treatment of degenerative disease. Through metabolite analysis, we are able to quantify the metabolites such as GABA and Glutamic Acid from the faecal sample after the treatment with bacterial strains but there is little significant result came.

English

ISBN: 9798310350601Subjects--Topical Terms:

3173021
Pharmaceutical sciences.
Subjects--Index Terms:

GABA

Investigating the Impact of Gamma-Aminobutyric Acid (GABA) Producing Probiotics on Healthy Aging /
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520 $a Aging is linked to reduced GABA production and gut microbiota changes, impacting metabolism and immunity. We hypothesize that a GABA-producing probiotic will enhance immune function and alter the metabolic profile of aging mice. This intervention may also improve intestinal barrier integrity and reduce inflammation, offering antiaging benefits. Declining gut lactic acid bacteria (LAB) and GABA levels may contribute to unhealthy aging and immune-related diseases. In our current study, we introduce the Lactococcus lactis strain IL1403 and Lactococcus lactis-P8s-GAD, a genetically engineered probiotic into the adult rats that increases the production of GABA in the gut and considered the subsequent impact on the microbial diversity through 16S rRNA sequencing, and developed proteomic and metabolic profiles in aging animals. We found significant differences in the body weight of animals up to 6 weeks of the study. However, we found a difference in the microbial diversity of the group treated with original bacterial strain IL1403 compared to other groups. Further we found little evidence of reduction in the ratio of firmicutes/bacteroidetes among the treatment group of animals, an indicator of oxidative stress among aged animals. In proteomic analysis, we able to express the number of proteins either upregulated or downregulated which play a crucial role in the pathophysiology of the different ailments and can target specific proteins for the diagnosis and treatment of degenerative disease. Through metabolite analysis, we are able to quantify the metabolites such as GABA and Glutamic Acid from the faecal sample after the treatment with bacterial strains but there is little significant result came.
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653 $a Probiotics
653 $a Proteomics
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710 2 $a Idaho State University. $b College of Pharmacy - Biomedical and Pharmaceutical Sciences. $e degree granting institution. $3 3821690
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