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Variability in the Hormone Environme...

Delahanty, Michelle Terese,

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Variability in the Hormone Environment Before and During Pregnancy and the Likelihood of Autism Spectrum Disorder /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Variability in the Hormone Environment Before and During Pregnancy and the Likelihood of Autism Spectrum Disorder // Michelle Terese Delahanty.
Author:	Delahanty, Michelle Terese,
Description:	1 electronic resource (136 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
Subject:	Epidemiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31846873
ISBN:	9798315714873

Variability in the Hormone Environment Before and During Pregnancy and the Likelihood of Autism Spectrum Disorder /
Delahanty, Michelle Terese,

Variability in the Hormone Environment Before and During Pregnancy and the Likelihood of Autism Spectrum Disorder /Michelle Terese Delahanty. - 1 electronic resource (136 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition for which the prevalence continues to increase. The etiology of ASD is hypothesized to include both genetic and environmental factors. Because ASD characteristics arise in the first few years of life, epidemiologic studies often focus on pregnancy-related exposures. Previous research implicates various hormonal exposures prior to and/or during pregnancy with atypical neurodevelopment in offspring, including thyroid dysfunction, cardiometabolic conditions, and endocrine disrupting chemicals. Few studies have investigated hormonal contraception and fertility treatments, two common reproductive exposures, in association with ASD. Results are inconclusive. This study aims: 1) to investigate the relationship between hormonal contraception used in the three months prior to pregnancy or continued during pregnancy in association with ASD, and 2) to investigate the relationship between fertility treatments in association with ASD overall and in a subgroup of participants with female-factor infertility.We used data from the Study to Explore Early Development (SEED) a multi-site case-control study of ASD in the U.S., with data collection in select states from 2007 to 2020. Children with and without ASD were identified from clinical/education sources and vital records, respectively, and enrolled at ages 2.5-5 years. We confirmed ASD case status by in-person developmental assessment. Both aims used the structured interview to define exposure status and adjusted logistic regression to calculate odds ratios and 95% confidence intervals. Results suggest no association between hormonal contraception and ovulation-inducing medications use prior to pregnancy and ASD. There was a suggestive association between hormonal contraception use during pregnancy and ASD. Results for all fertility treatments were attenuated in a subsample defined by a history of infertility compared to the overall sample. For exposures in both aims, confidence intervals were imprecise and reflected uncertainty.This research contributes to the body of evidence on the etiology of ASD. Additional research is needed on hormonal reproductive treatments and ASD, with careful consideration for exposure timing. Still, this research may reassure people with the capacity to become pregnant about the safety of treatments prior to conception.

English

ISBN: 9798315714873Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

Autism spectrum disorder

Variability in the Hormone Environment Before and During Pregnancy and the Likelihood of Autism Spectrum Disorder /
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520 $a Autism spectrum disorder (ASD) is a complex neurodevelopmental condition for which the prevalence continues to increase. The etiology of ASD is hypothesized to include both genetic and environmental factors. Because ASD characteristics arise in the first few years of life, epidemiologic studies often focus on pregnancy-related exposures. Previous research implicates various hormonal exposures prior to and/or during pregnancy with atypical neurodevelopment in offspring, including thyroid dysfunction, cardiometabolic conditions, and endocrine disrupting chemicals. Few studies have investigated hormonal contraception and fertility treatments, two common reproductive exposures, in association with ASD. Results are inconclusive. This study aims: 1) to investigate the relationship between hormonal contraception used in the three months prior to pregnancy or continued during pregnancy in association with ASD, and 2) to investigate the relationship between fertility treatments in association with ASD overall and in a subgroup of participants with female-factor infertility.We used data from the Study to Explore Early Development (SEED) a multi-site case-control study of ASD in the U.S., with data collection in select states from 2007 to 2020. Children with and without ASD were identified from clinical/education sources and vital records, respectively, and enrolled at ages 2.5-5 years. We confirmed ASD case status by in-person developmental assessment. Both aims used the structured interview to define exposure status and adjusted logistic regression to calculate odds ratios and 95% confidence intervals. Results suggest no association between hormonal contraception and ovulation-inducing medications use prior to pregnancy and ASD. There was a suggestive association between hormonal contraception use during pregnancy and ASD. Results for all fertility treatments were attenuated in a subsample defined by a history of infertility compared to the overall sample. For exposures in both aims, confidence intervals were imprecise and reflected uncertainty.This research contributes to the body of evidence on the etiology of ASD. Additional research is needed on hormonal reproductive treatments and ASD, with careful consideration for exposure timing. Still, this research may reassure people with the capacity to become pregnant about the safety of treatments prior to conception.
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