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HOXA1 and Quercetin as Key Regulator...

McCluskey, Elizabeth,

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HOXA1 and Quercetin as Key Regulators of Airway Epithelial Regeneration in COPD /

Record Type:	Electronic resources : Monograph/item
Title/Author:	HOXA1 and Quercetin as Key Regulators of Airway Epithelial Regeneration in COPD // Elizabeth McCluskey.
Author:	McCluskey, Elizabeth,
Description:	1 electronic resource (218 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
Subject:	Biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31767180
ISBN:	9798315760306

HOXA1 and Quercetin as Key Regulators of Airway Epithelial Regeneration in COPD /
McCluskey, Elizabeth,

HOXA1 and Quercetin as Key Regulators of Airway Epithelial Regeneration in COPD /Elizabeth McCluskey. - 1 electronic resource (218 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, structural remodeling, and impaired epithelial regeneration. The therapeutic potential of quercetin, a naturally occurring flavonoid, and HOXA1, a homeobox gene, in promoting epithelial repair and addressing COPD pathology, are studied. The findings demonstrate that quercetin enhances airway epithelial regeneration by modulating epigenetic mechanisms, promoting proper differentiation, and exerting anti-inflammatory effects. Specifically, quercetin treatment increased transepithelial resistance (TER), restored epithelial integrity, and normalized cell composition by increasing ciliated cells and reducing goblet cell hyperplasia. Furthermore, quercetin reduced pro-inflammatory cytokines, such as IL-6 and IL-8, suggesting its role in mitigating the chronic inflammatory state in COPD.In parallel, HOXA1's critical role as a regulator of epithelial repair is studied. HOXA1 deficiency was associated with impaired epithelial differentiation, delayed wound healing, and G1/S phase cell cycle arrest. HOXA1 knockout models revealed disrupted epithelial regeneration and abnormal airway structure, emphasizing the gene's importance in maintaining epithelial integrity. HOXA1's transcriptional regulation is further explored, underscoring a broader regulatory network involved in airway epithelial homeostasis.Together, these findings suggest a synergistic therapeutic potential of combining quercetin's multifaceted action with targeted modulation of HOXA1. This dual approach addresses multiple facets of COPD pathology, including inflammation, remodeling, and impaired repair processes. Further exploration of these therapeutic strategies, emphasizing their potential to provide more effective and personalized interventions for COPD and other chronic respiratory diseases is advocated for. These insights pave the way for innovative approaches to improve patient outcomes and quality of life.

English

ISBN: 9798315760306Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Chronic obstructive pulmonary disease

HOXA1 and Quercetin as Key Regulators of Airway Epithelial Regeneration in COPD /
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520 $a Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, structural remodeling, and impaired epithelial regeneration. The therapeutic potential of quercetin, a naturally occurring flavonoid, and HOXA1, a homeobox gene, in promoting epithelial repair and addressing COPD pathology, are studied. The findings demonstrate that quercetin enhances airway epithelial regeneration by modulating epigenetic mechanisms, promoting proper differentiation, and exerting anti-inflammatory effects. Specifically, quercetin treatment increased transepithelial resistance (TER), restored epithelial integrity, and normalized cell composition by increasing ciliated cells and reducing goblet cell hyperplasia. Furthermore, quercetin reduced pro-inflammatory cytokines, such as IL-6 and IL-8, suggesting its role in mitigating the chronic inflammatory state in COPD.In parallel, HOXA1's critical role as a regulator of epithelial repair is studied. HOXA1 deficiency was associated with impaired epithelial differentiation, delayed wound healing, and G1/S phase cell cycle arrest. HOXA1 knockout models revealed disrupted epithelial regeneration and abnormal airway structure, emphasizing the gene's importance in maintaining epithelial integrity. HOXA1's transcriptional regulation is further explored, underscoring a broader regulatory network involved in airway epithelial homeostasis.Together, these findings suggest a synergistic therapeutic potential of combining quercetin's multifaceted action with targeted modulation of HOXA1. This dual approach addresses multiple facets of COPD pathology, including inflammation, remodeling, and impaired repair processes. Further exploration of these therapeutic strategies, emphasizing their potential to provide more effective and personalized interventions for COPD and other chronic respiratory diseases is advocated for. These insights pave the way for innovative approaches to improve patient outcomes and quality of life.
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653 $a Chronic obstructive pulmonary disease
653 $a Transepithelial resistance
653 $a Quercetin
653 $a Inflammation
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