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Encapsulation of Hydrophobic Drugs I...

Li, Guanrui,

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Encapsulation of Hydrophobic Drugs Into Polymeric Nanoparticles During Polymerization Induced Self-Assembly (PISA) /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Encapsulation of Hydrophobic Drugs Into Polymeric Nanoparticles During Polymerization Induced Self-Assembly (PISA) // Guanrui Li.
Author:	Li, Guanrui,
Description:	1 electronic resource (249 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
Subject:	Chemical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31632837
ISBN:	9798302171559

Encapsulation of Hydrophobic Drugs Into Polymeric Nanoparticles During Polymerization Induced Self-Assembly (PISA) /
Li, Guanrui,

Encapsulation of Hydrophobic Drugs Into Polymeric Nanoparticles During Polymerization Induced Self-Assembly (PISA) /Guanrui Li. - 1 electronic resource (249 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Polymerization-induced self-assembly (PISA) is an efficient method for creating block copolymer nanoparticles, offering a simple platform for drug encapsulation. However, the impact of drug loading and block copolymer composition on nanoparticle shape and encapsulation efficiency remains unclear. Our first study explores the encapsulation of phenylacetic acid (PA) in poly(glycerol monomethacrylate)-block-poly(2-hydroxypropyl methacrylate) (PGMA-PHPMA) nanoparticles. Transmission electron microscopy and light scattering revealed that increasing PA loading shifts the nanoparticle morphology from spherical to cylindrical micelles, eventually forming vesicles, with a maximum encapsulation efficiency of 80% at 32 mg/mL. Surprisingly, varying the hydrophobic core block length had little effect, indicating PA associates mainly with the hydrophilic corona block. The investigation continued by replacing PGMA-PHPMA with poly(ethylene glycol) methyl ether (PEG)-PHPMA. With PA loading up to 16 mg/mL, PEG interacted with PA, leading to macrophase separation. PA facilitated the formation of PEG-PHPMA micelles, but their size and morphology remained unchanged until PA concentration reached 20 mg/mL. At the PEG-PHPMA/PA PISA system, PA was distributed among micelles, solvents, and other polymeric species, emphasizing the critical role of the hydrophilic corona block in drug encapsulation. Finally, we investigated acetaminophen (ACP) encapsulation in PEG-PHPMA and PGMA-PHPMA systems. Unlike the PEG-PHPMA/PA system, increasing ACP concentration did not impact the dispersion of PEG or PGMA. However, differences in ACP loading between the two systems led to distinct drug distributions, emphasizing the key roles of the corona block and drug properties in determining encapsulation efficiency and spatial distribution in PISA-formed nanoparticles.

English

ISBN: 9798302171559Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

Block copolymer nanoparticles

Encapsulation of Hydrophobic Drugs Into Polymeric Nanoparticles During Polymerization Induced Self-Assembly (PISA) /
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520 $a Polymerization-induced self-assembly (PISA) is an efficient method for creating block copolymer nanoparticles, offering a simple platform for drug encapsulation. However, the impact of drug loading and block copolymer composition on nanoparticle shape and encapsulation efficiency remains unclear. Our first study explores the encapsulation of phenylacetic acid (PA) in poly(glycerol monomethacrylate)-block-poly(2-hydroxypropyl methacrylate) (PGMA-PHPMA) nanoparticles. Transmission electron microscopy and light scattering revealed that increasing PA loading shifts the nanoparticle morphology from spherical to cylindrical micelles, eventually forming vesicles, with a maximum encapsulation efficiency of 80% at 32 mg/mL. Surprisingly, varying the hydrophobic core block length had little effect, indicating PA associates mainly with the hydrophilic corona block. The investigation continued by replacing PGMA-PHPMA with poly(ethylene glycol) methyl ether (PEG)-PHPMA. With PA loading up to 16 mg/mL, PEG interacted with PA, leading to macrophase separation. PA facilitated the formation of PEG-PHPMA micelles, but their size and morphology remained unchanged until PA concentration reached 20 mg/mL. At the PEG-PHPMA/PA PISA system, PA was distributed among micelles, solvents, and other polymeric species, emphasizing the critical role of the hydrophilic corona block in drug encapsulation. Finally, we investigated acetaminophen (ACP) encapsulation in PEG-PHPMA and PGMA-PHPMA systems. Unlike the PEG-PHPMA/PA system, increasing ACP concentration did not impact the dispersion of PEG or PGMA. However, differences in ACP loading between the two systems led to distinct drug distributions, emphasizing the key roles of the corona block and drug properties in determining encapsulation efficiency and spatial distribution in PISA-formed nanoparticles.
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650 4 $a Pharmacology. $3 634543
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653 $a Block copolymer nanoparticles
653 $a Drug delivery
653 $a Micelles
653 $a Polymerization induced self-assembly
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710 2 $a The Florida State University. $b Chemical & Biochemical Engineering. $e degree granting institution. $3 3827206
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