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A Minority of Th1 and Tfh Effector C...

Osum, Kevin Charles,

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A Minority of Th1 and Tfh Effector Cells Express Survival Genes Shared by Memory Cell Progeny and Require Il-7 or TCR Signaling to Persist /

Record Type:	Electronic resources : Monograph/item
Title/Author:	A Minority of Th1 and Tfh Effector Cells Express Survival Genes Shared by Memory Cell Progeny and Require Il-7 or TCR Signaling to Persist // Kevin Charles Osum.
Author:	Osum, Kevin Charles,
Description:	1 electronic resource (131 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
Contained By:	Dissertations Abstracts International86-05B.
Subject:	Immunology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31561777
ISBN:	9798342714167

A Minority of Th1 and Tfh Effector Cells Express Survival Genes Shared by Memory Cell Progeny and Require Il-7 or TCR Signaling to Persist /
Osum, Kevin Charles,

A Minority of Th1 and Tfh Effector Cells Express Survival Genes Shared by Memory Cell Progeny and Require Il-7 or TCR Signaling to Persist /Kevin Charles Osum. - 1 electronic resource (131 pages)

Source: Dissertations Abstracts International, Volume: 86-05, Section: B.

It is not clear how CD4+ memory T cells are formed from a much larger pool of earlier effector cells. We found that transient systemic bacterial infection rapidly generates several antigen-specific Th1 and T follicular helper (Tfh) effector cell populations with different tissue residence behaviors. Each Th1 and Tfh effector cell type produced a similar memory cell type, which was maintained by IL-7, or in the case of germinal center Tfh cells, by the T cell antigen receptor (TCR). Although most cells of all varieties had transcriptomes indicative of cell stress and death at the peak of the response, some had already acquired a quiescence signature. This thesis demonstrates that acute infection induces differentiation of Th1 and Tfh effector cells, a minority of which quickly adopt a transcriptional program that allows escape from death and become memory cells that survive from sensing IL-7 or a TCR ligand.

English

ISBN: 9798342714167Subjects--Topical Terms:

611031
Immunology.
Subjects--Index Terms:

Memory

A Minority of Th1 and Tfh Effector Cells Express Survival Genes Shared by Memory Cell Progeny and Require Il-7 or TCR Signaling to Persist /
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100 1 $a Osum, Kevin Charles, $e author. $3 3827197
245 1 2 $a A Minority of Th1 and Tfh Effector Cells Express Survival Genes Shared by Memory Cell Progeny and Require Il-7 or TCR Signaling to Persist / $c Kevin Charles Osum.
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300 $a 1 electronic resource (131 pages)
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337 $a computer $b c $2 rdamedia
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500 $a Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
500 $a Advisors: Jenkins, Marc K. Committee members: Fife, Brian; Masopust, David; Stromnes, Ingunn; Hogquist, Kris.
502 $b Ph.D. $c University of Minnesota $d 2024.
520 $a It is not clear how CD4+ memory T cells are formed from a much larger pool of earlier effector cells. We found that transient systemic bacterial infection rapidly generates several antigen-specific Th1 and T follicular helper (Tfh) effector cell populations with different tissue residence behaviors. Each Th1 and Tfh effector cell type produced a similar memory cell type, which was maintained by IL-7, or in the case of germinal center Tfh cells, by the T cell antigen receptor (TCR). Although most cells of all varieties had transcriptomes indicative of cell stress and death at the peak of the response, some had already acquired a quiescence signature. This thesis demonstrates that acute infection induces differentiation of Th1 and Tfh effector cells, a minority of which quickly adopt a transcriptional program that allows escape from death and become memory cells that survive from sensing IL-7 or a TCR ligand.
546 $a English
590 $a School code: 0130
650 4 $a Immunology. $3 611031
650 4 $a Cellular biology. $3 3172791
653 $a Memory
653 $a T cells
653 $a Cell stress
653 $a Quiescence signature
690 $a 0982
690 $a 0379
710 2 $a University of Minnesota. $b Microbiology, Immunology and Cancer Biology. $e degree granting institution. $3 3827198
720 1 $a Jenkins, Marc K. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-05B.
790 $a 0130
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31561777