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The Role of MAIT Cells in Colon Canc...

Cheng, Olivia Jessica,

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The Role of MAIT Cells in Colon Cancer and the Transcriptional Regulation of Their Effector Functions /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of MAIT Cells in Colon Cancer and the Transcriptional Regulation of Their Effector Functions // Olivia Jessica Cheng.
Author:	Cheng, Olivia Jessica,
Description:	1 electronic resource (80 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-08, Section: B.
Contained By:	Dissertations Abstracts International86-08B.
Subject:	Immunology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31557315
ISBN:	9798302872210

The Role of MAIT Cells in Colon Cancer and the Transcriptional Regulation of Their Effector Functions /
Cheng, Olivia Jessica,

The Role of MAIT Cells in Colon Cancer and the Transcriptional Regulation of Their Effector Functions /Olivia Jessica Cheng. - 1 electronic resource (80 pages)

Source: Dissertations Abstracts International, Volume: 86-08, Section: B.

This dissertation investigates the role of Mucosal-Associated Invariant T (MAIT) cells in colon cancer and their transcriptional regulation governing activation and effector functions.In Chapter 2, using a RAG1 knockout background, it is demonstrated that peritumoral injection of MAIT cells inhibits tumor growth in an MC38 mouse model. This intervention is associated with a notable increase in proinflammatory cytokines and cytokines modulating innate cell responses within the tumor microenvironment.Chapter 3 delves into the role of transcription factors STAT1, STAT3, STAT5, and HIF1α in regulating MAIT cell activation, effector functions, and glycolytic metabolism.These findings lay a foundation for future research aimed at integrating the study of transcriptional regulation of MAIT cell functions in disease models, particularly in colon cancer. The insights gained from this dissertation can be extended to explore broader aspects of MAIT cell functionality in various immune-related diseases.

English

ISBN: 9798302872210Subjects--Topical Terms:

611031
Immunology.
Subjects--Index Terms:

Mucosal-Associated Invariant T

The Role of MAIT Cells in Colon Cancer and the Transcriptional Regulation of Their Effector Functions /
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264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (80 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 86-08, Section: B.
500 $a Advisors: Leung, Daniel Ted Committee members: Tantin, Dean R.; Hale, Jeffrey Scott; Bettini, Maria; Rondina, Matthew Thomas.
502 $b Ph.D. $c The University of Utah $d 2024.
520 $a This dissertation investigates the role of Mucosal-Associated Invariant T (MAIT) cells in colon cancer and their transcriptional regulation governing activation and effector functions.In Chapter 2, using a RAG1 knockout background, it is demonstrated that peritumoral injection of MAIT cells inhibits tumor growth in an MC38 mouse model. This intervention is associated with a notable increase in proinflammatory cytokines and cytokines modulating innate cell responses within the tumor microenvironment.Chapter 3 delves into the role of transcription factors STAT1, STAT3, STAT5, and HIF1α in regulating MAIT cell activation, effector functions, and glycolytic metabolism.These findings lay a foundation for future research aimed at integrating the study of transcriptional regulation of MAIT cell functions in disease models, particularly in colon cancer. The insights gained from this dissertation can be extended to explore broader aspects of MAIT cell functionality in various immune-related diseases.
546 $a English
590 $a School code: 0240
650 4 $a Immunology. $3 611031
650 4 $a Cellular biology. $3 3172791
650 4 $a Oncology. $3 751006
650 4 $a Molecular biology. $3 517296
653 $a Mucosal-Associated Invariant T
653 $a Colon cancer
653 $a Transcriptional regulation
653 $a Glycolytic metabolism
653 $a Cytokines
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690 $a 0379
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710 2 $a The University of Utah. $b Pathology. $e degree granting institution. $3 3827192
720 1 $a Leung, Daniel Ted $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-08B.
790 $a 0240
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31557315