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The T Cell Receptor Guides Developme...

Viswanathan, Mayuri,

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The T Cell Receptor Guides Development, Polarization, and Peripheral Function of γδ T Cells /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The T Cell Receptor Guides Development, Polarization, and Peripheral Function of γδ T Cells // Mayuri Viswanathan.
Author:	Viswanathan, Mayuri,
Description:	1 electronic resource (93 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
Contained By:	Dissertations Abstracts International86-02B.
Subject:	Immunology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31556512
ISBN:	9798384011729

The T Cell Receptor Guides Development, Polarization, and Peripheral Function of γδ T Cells /
Viswanathan, Mayuri,

The T Cell Receptor Guides Development, Polarization, and Peripheral Function of γδ T Cells /Mayuri Viswanathan. - 1 electronic resource (93 pages)

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

γδ T cells occupy a unique immunological niche, bridging innate and adaptive immune function within a single cellular compartment. The lineage-defining γδ T cell receptor undergoes VDJ recombination in the thymus, but can recognize self-ligands, bind to ligands using germline encoded residues, and recognize antigens outside the context of MHC molecules. This dissertation addresses the still unknown role of the γδ TCR in postnatal thymic Vδ1+ T cell development, and shows that variation in the constant region of the γδ TCR durably influences thymic programming and peripheral function of γδ T cells. These roles for the γδ TCR in T cell function are distinct from known programs of αβ T cell development and function, and provide novel insights into the role of the γδ TCR in programming T cells in health and disease.

English

ISBN: 9798384011729Subjects--Topical Terms:

611031
Immunology.
Subjects--Index Terms:

Gamma delta T cells

The T Cell Receptor Guides Development, Polarization, and Peripheral Function of γδ T Cells /
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100 1 $a Viswanathan, Mayuri, $e author. $0 (orcid)0000-0002-8559-042X $3 3827189
245 1 0 $a The T Cell Receptor Guides Development, Polarization, and Peripheral Function of γδ T Cells / $c Mayuri Viswanathan.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (93 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
500 $a Advisors: Adams, Erin J. Committee members: Huang, Jun; Alegre, Marisa; Reder, Anthony T.
502 $b Ph.D. $c The University of Chicago $d 2024.
520 $a γδ T cells occupy a unique immunological niche, bridging innate and adaptive immune function within a single cellular compartment. The lineage-defining γδ T cell receptor undergoes VDJ recombination in the thymus, but can recognize self-ligands, bind to ligands using germline encoded residues, and recognize antigens outside the context of MHC molecules. This dissertation addresses the still unknown role of the γδ TCR in postnatal thymic Vδ1+ T cell development, and shows that variation in the constant region of the γδ TCR durably influences thymic programming and peripheral function of γδ T cells. These roles for the γδ TCR in T cell function are distinct from known programs of αβ T cell development and function, and provide novel insights into the role of the γδ TCR in programming T cells in health and disease.
546 $a English
590 $a School code: 0330
650 4 $a Immunology. $3 611031
650 4 $a Cellular biology. $3 3172791
650 4 $a Oncology. $3 751006
650 4 $a Biochemistry. $3 518028
653 $a Gamma delta T cells
653 $a T cell receptors
653 $a Unconventional T cell development
653 $a Functional polarization
653 $a Peripheral function
690 $a 0982
690 $a 0379
690 $a 0992
690 $a 0487
710 2 $a The University of Chicago. $b Interdisciplinary Scientist Training Program: Immunology. $e degree granting institution. $3 3827190
720 1 $a Adams, Erin J. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-02B.
790 $a 0330
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31556512