東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Heterogeneous Molecular Characterist...

Snow, Santina Marie,

Linked to FindBook

Google Book

Amazon

博客來

Heterogeneous Molecular Characteristics Lead to Disparate Colon Tumor Growth and Therapeutic Response /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Heterogeneous Molecular Characteristics Lead to Disparate Colon Tumor Growth and Therapeutic Response // Santina Marie Snow.
Author:	Snow, Santina Marie,
Description:	1 electronic resource (286 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
Contained By:	Dissertations Abstracts International86-01B.
Subject:	Oncology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31332202
ISBN:	9798383206102

Heterogeneous Molecular Characteristics Lead to Disparate Colon Tumor Growth and Therapeutic Response /
Snow, Santina Marie,

Heterogeneous Molecular Characteristics Lead to Disparate Colon Tumor Growth and Therapeutic Response /Santina Marie Snow. - 1 electronic resource (286 pages)

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

Tumorigenesis in the colon is a multi-step process. Colon polyps arise from two pathways, the classic adenoma to carcinoma sequence or the serrated pathway. Each pathway contains distinct molecular characteristics, which leads to variation between lesions or intertumoral heterogeneity. Though the genetic alterations for each pathway are well known, it is unclear which polyps will remain polyps, and which polyps will progress to invasive cancers. Intertumoral heterogeneity is also prevalent in colorectal cancers. Based on similar molecular characteristics, colorectal cancers can be subtyped to better understand treatment responses and patient outcomes. The current methodology to subtype colorectal cancers greatly limits its use in clinical practice, therefore, alternative methods have been developed and now require validation. Not all colorectal cancers within the same molecular subtype respond to the same therapies. This may be due to intra-tumoral heterogeneity or different clonal populations within a tumor. The development of new mouse models that recapitulate tumor heterogeneity would aid in understanding how heterogeneity impacts tumor development and response to therapies. This dissertation will explore how inter- and intra-tumoral heterogeneity at various stages in the continuum of normal colon to polyp to cancer impacts lesion growth and therapeutic response.

English

ISBN: 9798383206102Subjects--Topical Terms:

751006
Oncology.
Subjects--Index Terms:

Colon cancer

Heterogeneous Molecular Characteristics Lead to Disparate Colon Tumor Growth and Therapeutic Response /
LDR:02956nmm a22004453i 4500 001 2436497
005 20251023121228.5
006 m o d
007 cr|nu||||||||
008 261011s2024 miu||||||m |||||||eng d
020 $a 9798383206102
035 $a (MiAaPQD)AAI31332202
035 $a AAI31332202
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Snow, Santina Marie, $e author. $3 3827163
245 1 0 $a Heterogeneous Molecular Characteristics Lead to Disparate Colon Tumor Growth and Therapeutic Response / $c Santina Marie Snow.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (286 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
500 $a Advisors: Halberg, Richard B. Committee members: Deming, Dustin A.; Matkowskyj, Kristina A.; Miyamoto, Shigeki; Newton, Michael A.; Sugden, Bill.
502 $b Ph.D. $c The University of Wisconsin - Madison $d 2024.
520 $a Tumorigenesis in the colon is a multi-step process. Colon polyps arise from two pathways, the classic adenoma to carcinoma sequence or the serrated pathway. Each pathway contains distinct molecular characteristics, which leads to variation between lesions or intertumoral heterogeneity. Though the genetic alterations for each pathway are well known, it is unclear which polyps will remain polyps, and which polyps will progress to invasive cancers. Intertumoral heterogeneity is also prevalent in colorectal cancers. Based on similar molecular characteristics, colorectal cancers can be subtyped to better understand treatment responses and patient outcomes. The current methodology to subtype colorectal cancers greatly limits its use in clinical practice, therefore, alternative methods have been developed and now require validation. Not all colorectal cancers within the same molecular subtype respond to the same therapies. This may be due to intra-tumoral heterogeneity or different clonal populations within a tumor. The development of new mouse models that recapitulate tumor heterogeneity would aid in understanding how heterogeneity impacts tumor development and response to therapies. This dissertation will explore how inter- and intra-tumoral heterogeneity at various stages in the continuum of normal colon to polyp to cancer impacts lesion growth and therapeutic response.
546 $a English
590 $a School code: 0262
650 4 $a Oncology. $3 751006
650 4 $a Cellular biology. $3 3172791
650 4 $a Pathology. $3 643180
650 4 $a Immunology. $3 611031
653 $a Colon cancer
653 $a Colon polyps
653 $a Immune checkpoint inhibition
653 $a Therapeutics
653 $a Tumor heterogeneity
690 $a 0992
690 $a 0379
690 $a 0982
690 $a 0571
710 2 $a The University of Wisconsin - Madison. $b Cancer Biology. $e degree granting institution. $3 3827164
720 1 $a Halberg, Richard B. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-01B.
790 $a 0262
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31332202