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The Mitochondrial Membrane Potential...

McGlothen, Kendra,

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The Mitochondrial Membrane Potential as a Screening Tool for Immunostimulation /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Mitochondrial Membrane Potential as a Screening Tool for Immunostimulation // Kendra McGlothen.
Author:	McGlothen, Kendra,
Description:	1 electronic resource (194 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
Contained By:	Dissertations Abstracts International86-02B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31293726
ISBN:	9798383590188

The Mitochondrial Membrane Potential as a Screening Tool for Immunostimulation /
McGlothen, Kendra,

The Mitochondrial Membrane Potential as a Screening Tool for Immunostimulation /Kendra McGlothen. - 1 electronic resource (194 pages)

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

The rise of neuroinflammatory disorders highlights the importance of early detection and intervention for more effective treatment options. Neuroinflammation is associated with the pathogenesis of many neurological disorders, including Major Depressive Disorder, Alzheimer's disease, and Multiple Sclerosis. There has been a focus on neurons to advance our understanding of the underlying mechanisms of neuroinflammation and its role in neurodegeneration. However, recent studies have highlighted the pivotal role of glial cells, particularly microglia, in neuroinflammation due to their active participation in the immune response. This study investigates glial-specific indicators of morphology, metabolic changes, and drug efficacy in neuroinflammatory conditions. By analyzing the glial-specific activity of microglia at various levels, we uncover distinct patterns that correlate with disease progression. These findings offer insights into the early stages of neurological diseases and provide potential biomarkers for early detection. Moreover, this study explores the modulation of microglial metabolic activity as a screen for therapeutic approaches. We examine the impact of pharmacological interventions on glial cells and their subsequent effects on disease outcomes. In summary, this dissertation expands the current understanding of the dynamic interplay between glial cells, neuroinflammation, and disease progression, ultimately contributing to the development of a novel drug screening tool. Identifying glial-specific metabolic indicators and evaluating drug efficacy offer promising avenues for early detection and targeted therapeutic interventions in neurological diseases.

English

ISBN: 9798383590188Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Emapunil

The Mitochondrial Membrane Potential as a Screening Tool for Immunostimulation /
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100 1 $a McGlothen, Kendra, $e author. $0 (orcid)0000-0001-5250-1980 $3 3827142
245 1 0 $a The Mitochondrial Membrane Potential as a Screening Tool for Immunostimulation / $c Kendra McGlothen.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (194 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
500 $a Advisors: Hines, Dustin Committee members: Hines, Rochelle; McGinnis, Graham; Lee, David.
502 $b Ph.D. $c University of Nevada, Las Vegas $d 2024.
520 $a The rise of neuroinflammatory disorders highlights the importance of early detection and intervention for more effective treatment options. Neuroinflammation is associated with the pathogenesis of many neurological disorders, including Major Depressive Disorder, Alzheimer's disease, and Multiple Sclerosis. There has been a focus on neurons to advance our understanding of the underlying mechanisms of neuroinflammation and its role in neurodegeneration. However, recent studies have highlighted the pivotal role of glial cells, particularly microglia, in neuroinflammation due to their active participation in the immune response. This study investigates glial-specific indicators of morphology, metabolic changes, and drug efficacy in neuroinflammatory conditions. By analyzing the glial-specific activity of microglia at various levels, we uncover distinct patterns that correlate with disease progression. These findings offer insights into the early stages of neurological diseases and provide potential biomarkers for early detection. Moreover, this study explores the modulation of microglial metabolic activity as a screen for therapeutic approaches. We examine the impact of pharmacological interventions on glial cells and their subsequent effects on disease outcomes. In summary, this dissertation expands the current understanding of the dynamic interplay between glial cells, neuroinflammation, and disease progression, ultimately contributing to the development of a novel drug screening tool. Identifying glial-specific metabolic indicators and evaluating drug efficacy offer promising avenues for early detection and targeted therapeutic interventions in neurological diseases.
546 $a English
590 $a School code: 0506
650 4 $a Neurosciences. $3 588700
650 4 $a Microbiology. $3 536250
650 4 $a Cellular biology. $3 3172791
650 4 $a Molecular biology. $3 517296
650 4 $a Immunology. $3 611031
653 $a Emapunil
653 $a Lipopolysaccharide
653 $a Microglia
653 $a Mitochondrial membrane potential
653 $a Tetramethylrhodamine ethyl ester
690 $a 0317
690 $a 0379
690 $a 0410
690 $a 0982
690 $a 0307
710 2 $a University of Nevada, Las Vegas. $b Interdisciplinary Programs. $e degree granting institution. $3 3827143
720 1 $a Hines, Dustin $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-02B.
790 $a 0506
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31293726