東華大學圖書館 |

Pesticides, Telomere Length, & Cancer: Findings From the Agricultural Health Study /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Pesticides, Telomere Length, & Cancer: Findings From the Agricultural Health Study // Patricia Erickson.
Author:	Erickson, Patricia,
Description:	1 electronic resource (196 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Epidemiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31240420
ISBN:	9798383179925

Pesticides, Telomere Length, & Cancer: Findings From the Agricultural Health Study /
Erickson, Patricia,

Pesticides, Telomere Length, & Cancer: Findings From the Agricultural Health Study /Patricia Erickson. - 1 electronic resource (196 pages)

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Background: Previous studies have reported that specific pesticide exposures are associated with increased risks of certain malignancies, including non-Hodgkin lymphoma and prostate cancer. However, the mechanisms underlying these associations are not well understood. Many of these prior studies have focused on organochlorine and organophosphate pesticides; as a result, less is known about other pesticides. Moreover, most studies to date have been conducted in predominately male, occupational cohorts; consequently, less is known about risk of cancer at lower levels of exposures or among women.Objective: This dissertation was designed to examine: (a) the association between use of carbaryl and risk of cancer overall and by site among pesticide applicators in the Agricultural Health Study (AHS) cohort; (b) the association between carbaryl and risk of cancer overall and by site among female spouses of pesticide applicators in the AHS cohort, and (c) potential mechanisms of pesticide carcinogenesis by assessing the association between occupational pesticide use and relative leukocyte telomere length among pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study within the AHS.Methods: Data from the AHS, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina, and BEEA, a molecular sub-study of male pesticide applicators in the AHS, were used. The association between carbaryl exposure and risk of incident cancer among pesticide applicators and their female spouses was evaluated using Poisson regression. Linear regression models were used to assess the association between occupational pesticide use and relative telomere length (RTL) among pesticide applicators in BEEA.Results: Among 52,625 pesticide applicators in the AHS, approximately 50% reported use of carbaryl and 8,713 incident cancers were diagnosed. Increasing use of carbaryl was associated with an increased risk of stomach cancer (third tertile vs. never use; Risk Ratio (RR)T3=2.07, 95% Confidence Interval (CI): 1.05-4.07, p-trend=0.02). Ever use of carbaryl was associated with elevated risks of esophageal (RR=1.52, 95% CI: 1.01-2.27) and tongue (RR=1.91, 95% CI: 0.95-3.81) cancers, as well as aggressive prostate cancer when exposure was lagged by 30 years (RRQ4=1.56, 95% CI: 1.18-2.07, p-trend=0.002). Among 29,723 female spouses in the AHS cohort, 30% reported personal use of carbaryl and 4,157 incident cancers were identified. Personal use of carbaryl was associated with increased risks of stomach (RR=1.83, 95% CI: 0.90, 3.73), pancreatic (1.46, 95% CI: 0.97, 2.18), and uterine cancers (RR=1.15, 95% CI: 0.92, 1.42) as well as follicular lymphoma (RR: 1.54, 95% CI: 0.90, 2.61). Among 1,539 male pesticide applicators from BEEA, mean RTL was associated with increasing use of the insecticides lindane (highest quartile vs. never use: percent change = 4.51%, 95% CI -0.22% to 9.46%; p-trend=0.048) and diazinon (highest quartile vs. never use percent change=4.77%, 95% CI: 0.17 to 9.58, p-trend=0.055), as well as with ever-use of aldicarb (percent change=3.27, 95% CI: 0.23 to 6.40, p=0.035). Increasing use of the insecticide heptachlor or the herbicide 2,4,5-TP was inversely associated with RTL.Discussion: This dissertation provides novel evidence of potential associations between carbaryl use and increased risk of specific malignancies, including stomach cancer, which was noted among both pesticide applicators and their female spouses. These studies are the largest and most comprehensive of carbaryl to date and provide important insight into the carcinogenic potential of carbaryl. Moreover, analysis of the results from BEEA, particularly those related to lindane and diazinon, provides novel evidence that use of certain pesticides is associated with altered telomere length. As greater emphasis is placed upon mechanistic studies, these findings may inform future assessments of the carcinogenic potential of pesticides by organizations such as the International Agency for Research on Cancer, the United States Environmental Protection Agency, and other public health agencies.

English

ISBN: 9798383179925Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

Cancer

Pesticides, Telomere Length, & Cancer: Findings From the Agricultural Health Study /
LDR:05769nmm a22004693i 4500 001 2436482
005 20251023121224.5
006 m o d
007 cr|nu||||||||
008 261011s2024 miu||||||m |||||||eng d
020 $a 9798383179925
035 $a (MiAaPQD)AAI31240420
035 $a AAI31240420
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Erickson, Patricia, $e author. $3 3827135
245 1 0 $a Pesticides, Telomere Length, & Cancer: Findings From the Agricultural Health Study / $c Patricia Erickson.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (196 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
500 $a Advisors: Hughes Barry, Kathryn; Pereira, Edna Committee members: Beane Freeman, Laura E.; Hofmann, Jonathan N.; McDiarmid, Melissa A.; Sorkin, John D.
502 $b Ph.D. $c University of Maryland, Baltimore $d 2024.
520 $a Background: Previous studies have reported that specific pesticide exposures are associated with increased risks of certain malignancies, including non-Hodgkin lymphoma and prostate cancer. However, the mechanisms underlying these associations are not well understood. Many of these prior studies have focused on organochlorine and organophosphate pesticides; as a result, less is known about other pesticides. Moreover, most studies to date have been conducted in predominately male, occupational cohorts; consequently, less is known about risk of cancer at lower levels of exposures or among women.Objective: This dissertation was designed to examine: (a) the association between use of carbaryl and risk of cancer overall and by site among pesticide applicators in the Agricultural Health Study (AHS) cohort; (b) the association between carbaryl and risk of cancer overall and by site among female spouses of pesticide applicators in the AHS cohort, and (c) potential mechanisms of pesticide carcinogenesis by assessing the association between occupational pesticide use and relative leukocyte telomere length among pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study within the AHS.Methods: Data from the AHS, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina, and BEEA, a molecular sub-study of male pesticide applicators in the AHS, were used. The association between carbaryl exposure and risk of incident cancer among pesticide applicators and their female spouses was evaluated using Poisson regression. Linear regression models were used to assess the association between occupational pesticide use and relative telomere length (RTL) among pesticide applicators in BEEA.Results: Among 52,625 pesticide applicators in the AHS, approximately 50% reported use of carbaryl and 8,713 incident cancers were diagnosed. Increasing use of carbaryl was associated with an increased risk of stomach cancer (third tertile vs. never use; Risk Ratio (RR)T3=2.07, 95% Confidence Interval (CI): 1.05-4.07, p-trend=0.02). Ever use of carbaryl was associated with elevated risks of esophageal (RR=1.52, 95% CI: 1.01-2.27) and tongue (RR=1.91, 95% CI: 0.95-3.81) cancers, as well as aggressive prostate cancer when exposure was lagged by 30 years (RRQ4=1.56, 95% CI: 1.18-2.07, p-trend=0.002). Among 29,723 female spouses in the AHS cohort, 30% reported personal use of carbaryl and 4,157 incident cancers were identified. Personal use of carbaryl was associated with increased risks of stomach (RR=1.83, 95% CI: 0.90, 3.73), pancreatic (1.46, 95% CI: 0.97, 2.18), and uterine cancers (RR=1.15, 95% CI: 0.92, 1.42) as well as follicular lymphoma (RR: 1.54, 95% CI: 0.90, 2.61). Among 1,539 male pesticide applicators from BEEA, mean RTL was associated with increasing use of the insecticides lindane (highest quartile vs. never use: percent change = 4.51%, 95% CI -0.22% to 9.46%; p-trend=0.048) and diazinon (highest quartile vs. never use percent change=4.77%, 95% CI: 0.17 to 9.58, p-trend=0.055), as well as with ever-use of aldicarb (percent change=3.27, 95% CI: 0.23 to 6.40, p=0.035). Increasing use of the insecticide heptachlor or the herbicide 2,4,5-TP was inversely associated with RTL.Discussion: This dissertation provides novel evidence of potential associations between carbaryl use and increased risk of specific malignancies, including stomach cancer, which was noted among both pesticide applicators and their female spouses. These studies are the largest and most comprehensive of carbaryl to date and provide important insight into the carcinogenic potential of carbaryl. Moreover, analysis of the results from BEEA, particularly those related to lindane and diazinon, provides novel evidence that use of certain pesticides is associated with altered telomere length. As greater emphasis is placed upon mechanistic studies, these findings may inform future assessments of the carcinogenic potential of pesticides by organizations such as the International Agency for Research on Cancer, the United States Environmental Protection Agency, and other public health agencies.
546 $a English
590 $a School code: 0373
650 4 $a Epidemiology. $3 568544
650 4 $a Agriculture. $3 518588
650 4 $a Environmental health. $3 543032
650 4 $a Oncology. $3 751006
650 4 $a Agricultural chemistry. $3 523947
653 $a Cancer
653 $a Environmental exposures
653 $a Occupational exposures
653 $a Pesticides
653 $a Telomeres
690 $a 0766
690 $a 0992
690 $a 0749
690 $a 0470
690 $a 0473
710 2 $a University of Maryland, Baltimore. $b Epidemiology and Preventive Medicine. $e degree granting institution. $3 3827136
720 1 $a Hughes Barry, Kathryn $e degree supervisor.
720 1 $a Pereira, Edna $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-12B.
790 $a 0373
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31240420