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Sex-Specific Cardiac Effects of Mate...

Fang, Yun-Ju,

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Sex-Specific Cardiac Effects of Maternal and Offspring High-Fat, High-Sucrose Diets in C57BL/6J Mice /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Sex-Specific Cardiac Effects of Maternal and Offspring High-Fat, High-Sucrose Diets in C57BL/6J Mice // Yun-Ju Fang.
Author:	Fang, Yun-Ju,
Description:	1 electronic resource (78 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-11.
Contained By:	Masters Abstracts International86-11.
Subject:	Kinesiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32000238
ISBN:	9798314891643

Sex-Specific Cardiac Effects of Maternal and Offspring High-Fat, High-Sucrose Diets in C57BL/6J Mice /
Fang, Yun-Ju,

Sex-Specific Cardiac Effects of Maternal and Offspring High-Fat, High-Sucrose Diets in C57BL/6J Mice /Yun-Ju Fang. - 1 electronic resource (78 pages)

Source: Masters Abstracts International, Volume: 86-11.

Maternal obesity and exposure to high-fat, high-sucrose (HFHS) diets during development have been linked to long-term cardiometabolic risk in offspring. This study investigated the combined effects of prenatal and postnatal HFHS diet exposure on body composition and cardiac function in male and female mice. Offspring were maintained on the same diets as their dams (control [CON] or HFHS) until tissue collection at 29-32 weeks of age. Body weight and fat mass were significantly increased in HFHS groups, with males showing the greatest adiposity and final body weight. Lean mass was also higher in males, though lean mass relative to body weight declined with HFHS exposure. Cardiac assessments revealed both load-dependent and load-independent impairments. HFHS exposure led to increased end-diastolic and end-systolic volumes, reduced ejection fraction, and lower end-systolic elastance (Ees), consistent with systolic dysfunction. Diastolic function was compromised in a sex-specific manner: male HFHS animals exhibited reduced dP/dt min (relaxation), while female HFHS animals showed increased end-diastolic elastance (Eed), indicating elevated ventricular stiffness. Ventricular-arterial coupling, measured by Ees/Ea ratio, was reduced in HFHS animals of both sexes, with more pronounced impairments in females. These findings highlight sex-specific susceptibilities to HFHS-induced cardiovascular dysfunction, with female offspring exhibiting greater impairments in myocardial contractility and stiffness. This study underscores the need to consider sex as a biological variable in dietary programming research and supports the use of sex-specific approaches in cardiovascular disease prevention.

English

ISBN: 9798314891643Subjects--Topical Terms:

517627
Kinesiology.
Subjects--Index Terms:

Cardiovascular disease prevention

Sex-Specific Cardiac Effects of Maternal and Offspring High-Fat, High-Sucrose Diets in C57BL/6J Mice /
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520 $a Maternal obesity and exposure to high-fat, high-sucrose (HFHS) diets during development have been linked to long-term cardiometabolic risk in offspring. This study investigated the combined effects of prenatal and postnatal HFHS diet exposure on body composition and cardiac function in male and female mice. Offspring were maintained on the same diets as their dams (control [CON] or HFHS) until tissue collection at 29-32 weeks of age. Body weight and fat mass were significantly increased in HFHS groups, with males showing the greatest adiposity and final body weight. Lean mass was also higher in males, though lean mass relative to body weight declined with HFHS exposure. Cardiac assessments revealed both load-dependent and load-independent impairments. HFHS exposure led to increased end-diastolic and end-systolic volumes, reduced ejection fraction, and lower end-systolic elastance (Ees), consistent with systolic dysfunction. Diastolic function was compromised in a sex-specific manner: male HFHS animals exhibited reduced dP/dt min (relaxation), while female HFHS animals showed increased end-diastolic elastance (Eed), indicating elevated ventricular stiffness. Ventricular-arterial coupling, measured by Ees/Ea ratio, was reduced in HFHS animals of both sexes, with more pronounced impairments in females. These findings highlight sex-specific susceptibilities to HFHS-induced cardiovascular dysfunction, with female offspring exhibiting greater impairments in myocardial contractility and stiffness. This study underscores the need to consider sex as a biological variable in dietary programming research and supports the use of sex-specific approaches in cardiovascular disease prevention.
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653 $a Maternal obesity
653 $a End-systolic elastance
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