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Insights Into the Evolution of Chrom...

Wright, Dynisty,

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Insights Into the Evolution of Chromatin Architecture Generated by Inversion Breakpoints in Drosophila pseudoobscura /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Insights Into the Evolution of Chromatin Architecture Generated by Inversion Breakpoints in Drosophila pseudoobscura // Dynisty Wright.
Author:	Wright, Dynisty,
Description:	1 electronic resource (172 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
Contained By:	Dissertations Abstracts International85-05B.
Subject:	Gene expression. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30720652
ISBN:	9798380726863

Insights Into the Evolution of Chromatin Architecture Generated by Inversion Breakpoints in Drosophila pseudoobscura /
Wright, Dynisty,

Insights Into the Evolution of Chromatin Architecture Generated by Inversion Breakpoints in Drosophila pseudoobscura /Dynisty Wright. - 1 electronic resource (172 pages)

Source: Dissertations Abstracts International, Volume: 85-05, Section: B.

DNA is organized into chromosome territories, compartments, and topologically associated domains (TADs) within the nucleus. Chromosome rearrangements can alter this structure possibly leading to altered gene expression as well. The many mutations that can cause this are inversions, duplications, insertions, and more. In this thesis, we focus on inversion mutations. An inversion occurs when two breakpoints on one or two genes cause the sequence to orient in the opposite direction. In some species such as humans, inversions can cause negative effects; however, this does not occur in Drosophila. Instead, Drosophila harbors extensive inversion mutations, some of which are persistent in natural populations. Based on what we now know about chromatin architecture, we can understand more about the persisting inversions in Drosophila pseudoobscura. Chromatin architecture is vital throughout this thesis because we need to examine chromatin architecture to understand how TADs have evolved over a short-time scale. TADs are self-interacting domains that show preferential internal chromatin interactions with preferences for size, proteins, and structure involved in their formation. In D. pseudoobscura, seven different arrangements are separated by one persisting inversion: Standard (ST), Treeline (TL), Cuernavaca (CU), Pikes Peak (PP), Arrowhead (AR), Santa Cruz (SC), and Chiricahua (CH). We used TL and AR genomes to map TAD boundaries and breakpoints. We found that breakpoints are constrained to occur at boundaries possibly to prevent negative effects from occurring within D. pseudoobscura populations.

English

ISBN: 9798380726863Subjects--Topical Terms:

643979
Gene expression.
Subjects--Index Terms:

Natural populations

Insights Into the Evolution of Chromatin Architecture Generated by Inversion Breakpoints in Drosophila pseudoobscura /
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500 $a Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
500 $a Advisors: Schaeffer, Stephen Committee members: Perry, George P. J.; Mahony, Shaun; Toews, David; Mcgraw, Elizabeth.
502 $b Ph.D. $c The Pennsylvania State University $d 2023.
520 $a DNA is organized into chromosome territories, compartments, and topologically associated domains (TADs) within the nucleus. Chromosome rearrangements can alter this structure possibly leading to altered gene expression as well. The many mutations that can cause this are inversions, duplications, insertions, and more. In this thesis, we focus on inversion mutations. An inversion occurs when two breakpoints on one or two genes cause the sequence to orient in the opposite direction. In some species such as humans, inversions can cause negative effects; however, this does not occur in Drosophila. Instead, Drosophila harbors extensive inversion mutations, some of which are persistent in natural populations. Based on what we now know about chromatin architecture, we can understand more about the persisting inversions in Drosophila pseudoobscura. Chromatin architecture is vital throughout this thesis because we need to examine chromatin architecture to understand how TADs have evolved over a short-time scale. TADs are self-interacting domains that show preferential internal chromatin interactions with preferences for size, proteins, and structure involved in their formation. In D. pseudoobscura, seven different arrangements are separated by one persisting inversion: Standard (ST), Treeline (TL), Cuernavaca (CU), Pikes Peak (PP), Arrowhead (AR), Santa Cruz (SC), and Chiricahua (CH). We used TL and AR genomes to map TAD boundaries and breakpoints. We found that breakpoints are constrained to occur at boundaries possibly to prevent negative effects from occurring within D. pseudoobscura populations.
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650 4 $a Gene expression. $3 643979
650 4 $a Population genetics. $3 517299
650 4 $a Phylogenetics. $3 3561778
650 4 $a Mutation. $3 837917
650 4 $a Genetic engineering. $3 530509
650 4 $a Adaptation. $3 3562958
650 4 $a Insects. $3 516323
650 4 $a Genomes. $3 592593
650 4 $a Mosquitoes. $3 1244706
650 4 $a Genomics. $3 600531
650 4 $a Genetic diversity. $3 3685454
650 4 $a Polymorphism. $3 3560380
650 4 $a X chromosomes. $3 3561798
650 4 $a Molecular biology. $3 517296
650 4 $a Genetics. $3 530508
650 4 $a Biology. $3 522710
653 $a Natural populations
653 $a Gene expression
653 $a Chromosome territories
653 $a D. pseudoobscura
653 $a Inversion mutations
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710 2 $a The Pennsylvania State University. $e degree granting institution. $3 3765934
720 1 $a Schaeffer, Stephen $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-05B.
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792 $a 2023
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