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Design and Construction of Synthetic...

Jones, Ethan Mackenzie,

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Design and Construction of Synthetic Biology Tools for Sustainable Lanthanide Extraction /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Design and Construction of Synthetic Biology Tools for Sustainable Lanthanide Extraction // Ethan Mackenzie Jones.
Author:	Jones, Ethan Mackenzie,
Description:	1 electronic resource (135 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31239070
ISBN:	9798382775388

Design and Construction of Synthetic Biology Tools for Sustainable Lanthanide Extraction /
Jones, Ethan Mackenzie,

Design and Construction of Synthetic Biology Tools for Sustainable Lanthanide Extraction /Ethan Mackenzie Jones. - 1 electronic resource (135 pages)

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Lanthanides are critical elements used in numerous modern technologies, but their mining and purification pose significant environmental challenges. This thesis describes the development of synthetic biology tools to enable more sustainable extraction of lanthanides using engineered microbes. In Chapter 1, I engineer LanTERN, a first-of-its-kind fluorescent biosensor that directly transduces lanthanide binding into a fluorescent signal. LanTERN enables direct fluorescent detection of lanthanide binding, overcoming the limitations of previous sensors. Chapter 2 details early work on generating small, stable lanthanide-binding peptides through de novo design. Finally, Chapter 3 places this work in the broader context of synthetic microbiology for sustainability applications. I present a framework categorizing sustainability efforts based on their level of environmental containment and discuss research priorities for responsibly deploying engineered microbes. Together, the tools and perspectives provided help lay a foundation for engineering microbes to extract, concentrate, and separate lanthanides in a more environmentally friendly manner.

English

ISBN: 9798382775388Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Biosensor

Design and Construction of Synthetic Biology Tools for Sustainable Lanthanide Extraction /
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500 $a Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
500 $a Advisors: Silver, Pamela A. Committee members: Mitchison, Timothy; Yin, Peng; Polizzi, Nicholas.
502 $b Ph.D. $c Harvard University $d 2024.
520 $a Lanthanides are critical elements used in numerous modern technologies, but their mining and purification pose significant environmental challenges. This thesis describes the development of synthetic biology tools to enable more sustainable extraction of lanthanides using engineered microbes. In Chapter 1, I engineer LanTERN, a first-of-its-kind fluorescent biosensor that directly transduces lanthanide binding into a fluorescent signal. LanTERN enables direct fluorescent detection of lanthanide binding, overcoming the limitations of previous sensors. Chapter 2 details early work on generating small, stable lanthanide-binding peptides through de novo design. Finally, Chapter 3 places this work in the broader context of synthetic microbiology for sustainability applications. I present a framework categorizing sustainability efforts based on their level of environmental containment and discuss research priorities for responsibly deploying engineered microbes. Together, the tools and perspectives provided help lay a foundation for engineering microbes to extract, concentrate, and separate lanthanides in a more environmentally friendly manner.
546 $a English
590 $a School code: 0084
650 4 $a Biology. $3 522710
650 4 $a Biochemistry. $3 518028
650 4 $a Bioengineering. $3 657580
650 4 $a Systematic biology. $3 3173492
653 $a Biosensor
653 $a GCaMP
653 $a Lanthanides
653 $a Protein engineering
690 $a 0306
690 $a 0487
690 $a 0202
690 $a 0423
710 2 $a Harvard University. $b Systems Biology. $e degree granting institution. $3 3826130
720 1 $a Silver, Pamela A. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-12B.
790 $a 0084
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31239070