東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Quest for the Best Safety and Optimi...

Slingerland-Boot, Rianne,

FindBook

Google Book

Amazon

博客來

Quest for the Best Safety and Optimization of Nutrition Therapy During Critical Illness and Convalescence /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Quest for the Best Safety and Optimization of Nutrition Therapy During Critical Illness and Convalescence // Rianne Slingerland-Boot.
作者:	Slingerland-Boot, Rianne,
面頁冊數:	1 electronic resource (283 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-08, Section: B.
Contained By:	Dissertations Abstracts International86-08B.
標題:	Insulin resistance. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31876593
ISBN:	9798304988711

Quest for the Best Safety and Optimization of Nutrition Therapy During Critical Illness and Convalescence /
Slingerland-Boot, Rianne,

Quest for the Best Safety and Optimization of Nutrition Therapy During Critical Illness and Convalescence /Rianne Slingerland-Boot. - 1 electronic resource (283 pages)

Source: Dissertations Abstracts International, Volume: 86-08, Section: B.

Annually over 85.000 patients are admitted to Dutch Intensive care units (ICUs), a number expected to increase with an ageing population living longer with more chronic conditions. Even though the number of ICU survivors has steadily increased over the past decades, little is known about their long-term health. Despite the observed reduction in ICU mortality, the long-term consequences of ICU admission are a growing concern as more patients are dismissed to rehabilitation centres. Moreover, an increase in physical and functional disabilities with a decrease in quality of life (QoL) has been reported. Many ICU survivors suffer from prolonged physical, mental and cognitive health problems, and even for ICU survivors who do not experience these issues, (complete) recovery can take an unexpectedly long time. These observations may lead to the question: "Are we creating survivors... or victims in critical care?" .Nonetheless, there are minimal evidence-based therapies to enhance recovery and thus optimise QoL in the post-ICU convalescence. Undoubtedly, recovery after the acute phase of critical illness can only be accomplished with adequate nutrition, particularly proteins. However, the disrupted metabolism (including mitochondrial dysfunction) during critical illness has implications for nutrition therapy. Therefore, this thesis aims to increase knowledge about the nutritional journey of critically ill patients in the ICU and post-ICU period, with the ultimate goal of improving current nutritional strategies and preventing adverse effects.In this thesis several aspects of nutritional therapy during ICU stay were investigated, including some metabolic interactions of macronutrient administration during refeeding syndrome. In addition, the evolution of mitochondrial dysfunction during sepsis was studied, as well as the impact of continuous sedation (which in vivo suppresses mitochondrial function) on clinical outcomes, as this has consequences for nutritional support. Finally, it was examined what happens to nutrition during the postICU hospitalization period, including possible associations with clinical outcomes.

English

ISBN: 9798304988711Subjects--Topical Terms:

1016456
Insulin resistance.
Subjects--Index Terms:

Intensive care units

Quest for the Best Safety and Optimization of Nutrition Therapy During Critical Illness and Convalescence /
LDR:03665nmm a22004453i 4500 001 2435659
005 20251009122902.5
006 m o d
007 cr|nu||||||||
008 261011s2025 miu||||||m |||||||eng d
020 $a 9798304988711
035 $a (MiAaPQD)AAI31876593
035 $a (MiAaPQD)Wageningen639001
035 $a AAI31876593
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Slingerland-Boot, Rianne, $e author. $3 3826036
245 1 0 $a Quest for the Best Safety and Optimization of Nutrition Therapy During Critical Illness and Convalescence / $c Rianne Slingerland-Boot.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2025
300 $a 1 electronic resource (283 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-08, Section: B.
500 $a Advisors: van Zanten, Arthur; Mensink, Marco.
502 $b Ph.D. $c Wageningen University and Research $d 2025.
520 $a Annually over 85.000 patients are admitted to Dutch Intensive care units (ICUs), a number expected to increase with an ageing population living longer with more chronic conditions. Even though the number of ICU survivors has steadily increased over the past decades, little is known about their long-term health. Despite the observed reduction in ICU mortality, the long-term consequences of ICU admission are a growing concern as more patients are dismissed to rehabilitation centres. Moreover, an increase in physical and functional disabilities with a decrease in quality of life (QoL) has been reported. Many ICU survivors suffer from prolonged physical, mental and cognitive health problems, and even for ICU survivors who do not experience these issues, (complete) recovery can take an unexpectedly long time. These observations may lead to the question: "Are we creating survivors... or victims in critical care?" .Nonetheless, there are minimal evidence-based therapies to enhance recovery and thus optimise QoL in the post-ICU convalescence. Undoubtedly, recovery after the acute phase of critical illness can only be accomplished with adequate nutrition, particularly proteins. However, the disrupted metabolism (including mitochondrial dysfunction) during critical illness has implications for nutrition therapy. Therefore, this thesis aims to increase knowledge about the nutritional journey of critically ill patients in the ICU and post-ICU period, with the ultimate goal of improving current nutritional strategies and preventing adverse effects.In this thesis several aspects of nutritional therapy during ICU stay were investigated, including some metabolic interactions of macronutrient administration during refeeding syndrome. In addition, the evolution of mitochondrial dysfunction during sepsis was studied, as well as the impact of continuous sedation (which in vivo suppresses mitochondrial function) on clinical outcomes, as this has consequences for nutritional support. Finally, it was examined what happens to nutrition during the postICU hospitalization period, including possible associations with clinical outcomes.
546 $a English
590 $a School code: 2157
650 4 $a Insulin resistance. $3 1016456
650 4 $a Ventilators. $3 3685015
650 4 $a Lipids. $3 558980
650 4 $a Respiration. $3 610890
650 4 $a Mortality. $3 533218
650 4 $a Adenosine triphosphate. $3 3331834
650 4 $a Adenosine diphosphate. $3 3768687
650 4 $a Health sciences. $3 3168359
650 4 $a Nutrition. $3 517777
653 $a Intensive care units
653 $a Quality of life
653 $a Nutritional strategies
653 $a Refeeding syndrome
690 $a 0566
690 $a 0769
690 $a 0570
710 2 $a Wageningen University and Research. $e degree granting institution. $3 3815267
720 1 $a van Zanten, Arthur $e degree supervisor.
720 1 $a Mensink, Marco $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-08B.
790 $a 2157
791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31876593