東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The Role of the Omega-3 Polyunsatura...

Lovins, Hannah Brooke,

Linked to FindBook

Google Book

Amazon

博客來

The Role of the Omega-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, and Its Downstream Pro-Resolving Mediators in Ozone-Induced Airspace Inflammation /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of the Omega-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, and Its Downstream Pro-Resolving Mediators in Ozone-Induced Airspace Inflammation // Hannah Brooke Lovins.
Author:	Lovins, Hannah Brooke,
Description:	1 electronic resource (145 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
Subject:	Nutrition. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32111870
ISBN:	9798314890035

The Role of the Omega-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, and Its Downstream Pro-Resolving Mediators in Ozone-Induced Airspace Inflammation /
Lovins, Hannah Brooke,

The Role of the Omega-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, and Its Downstream Pro-Resolving Mediators in Ozone-Induced Airspace Inflammation /Hannah Brooke Lovins. - 1 electronic resource (145 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

Ambient concentrations of the air pollutant, ozone, are rising with increasing global temperatures. Ozone is known to increase incidence and exacerbation of chronic lung diseases, which will increase as ambient ozone levels rise. Studies have identified diet as a variable that is able to modulate the pulmonary health effects associated with ozone exposure. Eicosapentaenoic acid (EPA) is an n-3 (?-3) PUFA consumed through diet, which lowers inflammation through conversion to oxylipins including hydroxy-eicosapentaenoic acids (HEPEs) and the Specialized Pro-Resolving Lipid Mediator (SPM), Resolvin E1 (RvE1). We have previously shown ozone exposure downregulates expression of the RvE1 receptor, CHEMR23. RvE1 signaling through CHEMR23 drives resolution of inflammation. However, the role of dietary EPA and its downstream signaling of RvE1 and CHEMR23 in ozone-induced pulmonary inflammation is unknown. Therefore, we hypothesized that increasing dietary EPA will decrease ozone-induced pulmonary inflammation and injury through the production of HEPEs and RvE1, and that the absence of the CHEMR23 receptor will augment ozone-induced pulmonary inflammation.To test this hypothesis, we divided it into two projects. First, we utilized an EPA-supplemented diet along with 5-HEPE and 12-HEPE treatment in wildtype C57BL/6J mice to identify whether EPA supplementation leads to protection from ozone-induced pulmonary inflammation. Bronchoalveolar lavage and lung tissue were harvested and analyzed for markers of inflammation, injury, and the pulmonary lipidome. Additionally, we utilized a CHEMR23 whole-body knockout mouse model to evaluate the mechanism by which EPA inhibits ozone-induced inflammation through the RvE1/CHEMR23 signaling axis. Bronchoalveolar lavage, lung tissue, and adipose tissue were collected to measure inflammation and injury. Additionally, CHEMR23 KO bone marrow chimeras were used to evaluate the hemopoietic role of CHEMR23 signaling following ozone exposure.Together, our data indicates that an EPA-supplemented diet protects against ozone-induced airspace inflammation which is, in part, due to increasing pulmonary amounts of 5-HEPEs and 12-HEPEs. Additionally, RvE1 signaling through CHEMR23, in part, protects against ozone-induced inflammation. These findings suggest that dietary EPA in the lung can reduce ozone-driven incidences and exacerbations of chronic pulmonary diseases through metabolism to oxylipins including RvE1, which binds CHEMR23.

English

ISBN: 9798314890035Subjects--Topical Terms:

517777
Nutrition.
Subjects--Index Terms:

Eicosapentaenoic acid

The Role of the Omega-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, and Its Downstream Pro-Resolving Mediators in Ozone-Induced Airspace Inflammation /
LDR:04074nmm a22004453i 4500 001 2435238
005 20251001062520.5
006 m o d
007 cr|nu||||||||
008 261011s2025 miu||||||m |||||||eng d
020 $a 9798314890035
035 $a (MiAaPQD)AAI32111870
035 $a AAI32111870
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Lovins, Hannah Brooke, $e author. $3 3825477
245 1 0 $a The Role of the Omega-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, and Its Downstream Pro-Resolving Mediators in Ozone-Induced Airspace Inflammation / $c Hannah Brooke Lovins.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2025
300 $a 1 electronic resource (145 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
500 $a Advisors: Gowdy, Kymberly M. Committee members: Britt, Rodney; Davis, Ian; Wold, Loren E.; Belury, Martha; Shaikh, Saame Raza.
502 $b Ph.D. $c The Ohio State University $d 2025.
520 $a Ambient concentrations of the air pollutant, ozone, are rising with increasing global temperatures. Ozone is known to increase incidence and exacerbation of chronic lung diseases, which will increase as ambient ozone levels rise. Studies have identified diet as a variable that is able to modulate the pulmonary health effects associated with ozone exposure. Eicosapentaenoic acid (EPA) is an n-3 (?-3) PUFA consumed through diet, which lowers inflammation through conversion to oxylipins including hydroxy-eicosapentaenoic acids (HEPEs) and the Specialized Pro-Resolving Lipid Mediator (SPM), Resolvin E1 (RvE1). We have previously shown ozone exposure downregulates expression of the RvE1 receptor, CHEMR23. RvE1 signaling through CHEMR23 drives resolution of inflammation. However, the role of dietary EPA and its downstream signaling of RvE1 and CHEMR23 in ozone-induced pulmonary inflammation is unknown. Therefore, we hypothesized that increasing dietary EPA will decrease ozone-induced pulmonary inflammation and injury through the production of HEPEs and RvE1, and that the absence of the CHEMR23 receptor will augment ozone-induced pulmonary inflammation.To test this hypothesis, we divided it into two projects. First, we utilized an EPA-supplemented diet along with 5-HEPE and 12-HEPE treatment in wildtype C57BL/6J mice to identify whether EPA supplementation leads to protection from ozone-induced pulmonary inflammation. Bronchoalveolar lavage and lung tissue were harvested and analyzed for markers of inflammation, injury, and the pulmonary lipidome. Additionally, we utilized a CHEMR23 whole-body knockout mouse model to evaluate the mechanism by which EPA inhibits ozone-induced inflammation through the RvE1/CHEMR23 signaling axis. Bronchoalveolar lavage, lung tissue, and adipose tissue were collected to measure inflammation and injury. Additionally, CHEMR23 KO bone marrow chimeras were used to evaluate the hemopoietic role of CHEMR23 signaling following ozone exposure.Together, our data indicates that an EPA-supplemented diet protects against ozone-induced airspace inflammation which is, in part, due to increasing pulmonary amounts of 5-HEPEs and 12-HEPEs. Additionally, RvE1 signaling through CHEMR23, in part, protects against ozone-induced inflammation. These findings suggest that dietary EPA in the lung can reduce ozone-driven incidences and exacerbations of chronic pulmonary diseases through metabolism to oxylipins including RvE1, which binds CHEMR23.
546 $a English
590 $a School code: 0168
650 4 $a Nutrition. $3 517777
650 4 $a Biochemistry. $3 518028
650 4 $a Biology. $3 522710
650 4 $a Environmental health. $3 543032
650 4 $a Immunology. $3 611031
653 $a Eicosapentaenoic acid
653 $a Air pollutant
653 $a Ozone levels
653 $a Chronic pulmonary diseases
690 $a 0570
690 $a 0487
690 $a 0306
690 $a 0982
690 $a 0470
710 2 $a The Ohio State University. $b Molecular, Cellular and Developmental Biology. $e degree granting institution. $3 3825478
720 1 $a Gowdy, Kymberly M. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-11B.
790 $a 0168
791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32111870