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Development of Flexible Lactate-Spec...

Animashaun, Christopher,

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Development of Flexible Lactate-Specific Molecularly Imprinted Polymers Based on Laser-Induced Graphene Electrochemical Biosensors for Disease Diagnosis /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of Flexible Lactate-Specific Molecularly Imprinted Polymers Based on Laser-Induced Graphene Electrochemical Biosensors for Disease Diagnosis // Christopher Animashaun.
Author:	Animashaun, Christopher,
Description:	1 electronic resource (129 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
Contained By:	Dissertations Abstracts International86-12B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32038508
ISBN:	9798280750531

Development of Flexible Lactate-Specific Molecularly Imprinted Polymers Based on Laser-Induced Graphene Electrochemical Biosensors for Disease Diagnosis /
Animashaun, Christopher,

Development of Flexible Lactate-Specific Molecularly Imprinted Polymers Based on Laser-Induced Graphene Electrochemical Biosensors for Disease Diagnosis /Christopher Animashaun. - 1 electronic resource (129 pages)

Source: Dissertations Abstracts International, Volume: 86-12, Section: B.

Lactate is a critical biomarker linked to conditions such as sepsis, ischemia, cancer, and heart failure. Current lactate detection methods remain invasive, costly, and unsuitable for real-time, continuous monitoring. This study presents the development of a flexible, non-enzymatic electrochemical biosensor based on laser-induced graphene (LIG) electrodes modified with gold nanoparticles (AuNPs) and molecularly imprinted polymers (MIPs) for highly selective and sensitive lactate measurement. The integration of AuNPs enhanced surface conductivity and provided nanoscale heterogeneity, facilitating superior signal amplification. The optimized LIG/AuNP/MIP sensor achieved an extensive dynamic detection range from 0.1 µM to 1000 µM, with an outstanding detection limit of 0.033 µM and a strong linear correlation (R² = 0.9556). The biosensor exhibited excellent selectivity against common interferents such as glucose, uric acid, ascorbic acid, and potassium ions. Stability studies demonstrated robust performance after prolonged storage at 4 °C, with regeneration enabled via CTAB treatment. Validation using artificial saliva yielded recovery rates between 102% and 113%, confirming accuracy in complex biological matrices. Mechanical tests further confirmed exceptional flexibility, with ~98% signal retention after mechanical twisting, supporting its application in wearable technologies. Compared to conventional enzymatic and non-enzymatic platforms, the LIG/AuNP/MIP biosensor offers enhanced sensitivity, stability, and durability. These findings establish a strong foundation for the future development of integrated, non-invasive, continuous lactate monitoring devices suitable for athletic performance tracking, critical care diagnostics, and personalized health management.

English

ISBN: 9798280750531Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Electrochemical sensing

Development of Flexible Lactate-Specific Molecularly Imprinted Polymers Based on Laser-Induced Graphene Electrochemical Biosensors for Disease Diagnosis /
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520 $a Lactate is a critical biomarker linked to conditions such as sepsis, ischemia, cancer, and heart failure. Current lactate detection methods remain invasive, costly, and unsuitable for real-time, continuous monitoring. This study presents the development of a flexible, non-enzymatic electrochemical biosensor based on laser-induced graphene (LIG) electrodes modified with gold nanoparticles (AuNPs) and molecularly imprinted polymers (MIPs) for highly selective and sensitive lactate measurement. The integration of AuNPs enhanced surface conductivity and provided nanoscale heterogeneity, facilitating superior signal amplification. The optimized LIG/AuNP/MIP sensor achieved an extensive dynamic detection range from 0.1 µM to 1000 µM, with an outstanding detection limit of 0.033 µM and a strong linear correlation (R² = 0.9556). The biosensor exhibited excellent selectivity against common interferents such as glucose, uric acid, ascorbic acid, and potassium ions. Stability studies demonstrated robust performance after prolonged storage at 4 °C, with regeneration enabled via CTAB treatment. Validation using artificial saliva yielded recovery rates between 102% and 113%, confirming accuracy in complex biological matrices. Mechanical tests further confirmed exceptional flexibility, with ~98% signal retention after mechanical twisting, supporting its application in wearable technologies. Compared to conventional enzymatic and non-enzymatic platforms, the LIG/AuNP/MIP biosensor offers enhanced sensitivity, stability, and durability. These findings establish a strong foundation for the future development of integrated, non-invasive, continuous lactate monitoring devices suitable for athletic performance tracking, critical care diagnostics, and personalized health management.
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