東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Catching Up! : Rational Design of Bi...

Galen, Martijn Van,

Linked to FindBook

Google Book

Amazon

博客來

Catching Up! : Rational Design of Bio-Inspired Catch Bonds /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Catching Up! : Rational Design of Bio-Inspired Catch Bonds // Martijn Van Galen.
Author:	Galen, Martijn Van,
Description:	1 electronic resource (266 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
Contained By:	Dissertations Abstracts International86-02B.
Subject:	Mechanical properties. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31206426
ISBN:	9798383709641

Catching Up! : Rational Design of Bio-Inspired Catch Bonds /
Galen, Martijn Van,

Catching Up! : Rational Design of Bio-Inspired Catch Bonds /Martijn Van Galen. - 1 electronic resource (266 pages)

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

"Nothing is invented, for it is written in nature first. - Antoni Gaudi"Living organisms are continuously exposed to mechanical forces. These include external forces such as gravity, pressure exerted by the atmosphere, and mechanical interactions between organisms. Forces can also originate within organisms, such as in muscle contraction, or in the turgor pressure exerted within plant cells. In response to these stimuli, nature has evolved a wide range of force-sensitive mechanisms that act at multiple length scales. At the largest length scale, such mechanisms involve the structure of organisms as a whole. For example, the peregrine falcon can reshape its body to minimize aerodynamic drag forces, allowing it to dive at high speeds1. At smaller length scales, mechanisms involve the structures of cells and tissues. For instance, plant tissues acquire their rigidity by balancing external forces between neighboring cells against the cells' internal turgor pressures2. At the foundation of such force-responsive mechanisms at larger length scales are mechanisms at the molecular scale: mechanosensitive proteins allow cells to translate mechanical forces into biochemical signals. Striking examples of these are mechanically-activated ion channels, which allow ions to pass into cells only when exposed to mechanical forces3,4, or mechanocatalytic enzymes such or ATP synthase, which acts as a molecular turbine that utilizes rotational torques induced by chemical gradients to catalyze ATP production5,6.Throughout history, the elegant force-responsive mechanisms present in nature have inspired the development of man-made structures and materials, in a process known as biomimicry. Since many artificial materials are exposed to the same forces natural systems have been exposed to for billions of years, biomimicry allows us to learn from the solutions nature has invented and exploit these in artificial systems. Such biomimetic systems have been developed over the variety of length scales, ranging from organisms, to cells, to molecules. At the level of organisms, one can think of the columns in the Sagrada Familia Basilica in Barcelona. Inspired by the structure of trees, these columns gradually branch out to support the weight of the vaulted ceiling (fig. 1.1a). At the cellular level, naturally occurring networks of biopolymers in the cell wall and cartilage have inspired the development of synthetic double networks7--9. Like their biological analogues, these double networks combine strong but brittle polymers with elastic ones to obtain composite materials that are both strong and tough (fig. 1.1b).In spite of the advancements at larger length scales, biomimicry at the molecular length scale remains challenging. Although progress in recent years has led to the development of biomimetic mechanocatalytic systems10,11, a vital class of uniquely force-responsive proteins remains unmimicked to date: catch bonds. Catch bonds are counter-intuitive protein bonds that strengthen under increasing tension (fig. 1c). Such bonds are widely found throughout biology in proteins experiencing large mechanical stresses, such as cytoskeletal cross-linkers, proteins involved in cellular adhesion, and the transduction of mechanical forces. Through their unique response to tension, catch bonds provide strength-on-demand, allowing them to maintain cellular integrity when exposed large forces, while guaranteeing plasticity when at rest. Incorporating catch bonds in synthetic materials could enable a new class of materials that combine plasticity and strength.

English

ISBN: 9798383709641Subjects--Topical Terms:

3549505
Mechanical properties.

Catching Up! : Rational Design of Bio-Inspired Catch Bonds /
LDR:05003nmm a22004573i 4500 001 2435102
005 20251001062451.5
006 m o d
007 cr|nu||||||||
008 261011s2024 miu||||||m |||||||eng d
020 $a 9798383709641
035 $a (MiAaPQD)AAI31206426
035 $a (MiAaPQD)Wageningen626183
035 $a AAI31206426
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Galen, Martijn Van, $e author. $3 3825294
245 1 0 $a Catching Up! : Rational Design of Bio-Inspired Catch Bonds / $c Martijn Van Galen.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (266 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
500 $a Advisors: Sprakel, Joris; Albada, Bauke.
502 $b Ph.D. $c Wageningen University and Research $d 2024.
520 $a "Nothing is invented, for it is written in nature first. - Antoni Gaudi"Living organisms are continuously exposed to mechanical forces. These include external forces such as gravity, pressure exerted by the atmosphere, and mechanical interactions between organisms. Forces can also originate within organisms, such as in muscle contraction, or in the turgor pressure exerted within plant cells. In response to these stimuli, nature has evolved a wide range of force-sensitive mechanisms that act at multiple length scales. At the largest length scale, such mechanisms involve the structure of organisms as a whole. For example, the peregrine falcon can reshape its body to minimize aerodynamic drag forces, allowing it to dive at high speeds1. At smaller length scales, mechanisms involve the structures of cells and tissues. For instance, plant tissues acquire their rigidity by balancing external forces between neighboring cells against the cells' internal turgor pressures2. At the foundation of such force-responsive mechanisms at larger length scales are mechanisms at the molecular scale: mechanosensitive proteins allow cells to translate mechanical forces into biochemical signals. Striking examples of these are mechanically-activated ion channels, which allow ions to pass into cells only when exposed to mechanical forces3,4, or mechanocatalytic enzymes such or ATP synthase, which acts as a molecular turbine that utilizes rotational torques induced by chemical gradients to catalyze ATP production5,6.Throughout history, the elegant force-responsive mechanisms present in nature have inspired the development of man-made structures and materials, in a process known as biomimicry. Since many artificial materials are exposed to the same forces natural systems have been exposed to for billions of years, biomimicry allows us to learn from the solutions nature has invented and exploit these in artificial systems. Such biomimetic systems have been developed over the variety of length scales, ranging from organisms, to cells, to molecules. At the level of organisms, one can think of the columns in the Sagrada Familia Basilica in Barcelona. Inspired by the structure of trees, these columns gradually branch out to support the weight of the vaulted ceiling (fig. 1.1a). At the cellular level, naturally occurring networks of biopolymers in the cell wall and cartilage have inspired the development of synthetic double networks7--9. Like their biological analogues, these double networks combine strong but brittle polymers with elastic ones to obtain composite materials that are both strong and tough (fig. 1.1b).In spite of the advancements at larger length scales, biomimicry at the molecular length scale remains challenging. Although progress in recent years has led to the development of biomimetic mechanocatalytic systems10,11, a vital class of uniquely force-responsive proteins remains unmimicked to date: catch bonds. Catch bonds are counter-intuitive protein bonds that strengthen under increasing tension (fig. 1c). Such bonds are widely found throughout biology in proteins experiencing large mechanical stresses, such as cytoskeletal cross-linkers, proteins involved in cellular adhesion, and the transduction of mechanical forces. Through their unique response to tension, catch bonds provide strength-on-demand, allowing them to maintain cellular integrity when exposed large forces, while guaranteeing plasticity when at rest. Incorporating catch bonds in synthetic materials could enable a new class of materials that combine plasticity and strength.
546 $a English
590 $a School code: 2157
650 4 $a Mechanical properties. $3 3549505
650 4 $a Urogenital system. $3 3705906
650 4 $a Synthetic products. $3 770075
650 4 $a Biochemistry. $3 518028
650 4 $a Binding sites. $3 3560349
650 4 $a Leukocytes. $3 3773216
650 4 $a Adhesion. $3 818212
650 4 $a Biology. $3 522710
650 4 $a Energy. $3 876794
650 4 $a Nanotechnology. $3 526235
650 4 $a Composite materials. $3 654082
650 4 $a Cells. $3 634126
650 4 $a Design. $3 518875
650 4 $a Chemical bonds. $3 560512
650 4 $a Lectins. $3 1621162
650 4 $a Hydrogels. $3 1305894
650 4 $a Shear stress. $3 3681838
650 4 $a Materials science. $3 543314
650 4 $a Mechanics. $3 525881
650 4 $a Morphology. $3 591167
690 $a 0791
690 $a 0389
690 $a 0487
690 $a 0306
690 $a 0652
690 $a 0794
690 $a 0346
690 $a 0287
710 2 $a Wageningen University and Research. $e degree granting institution. $3 3815267
720 1 $a Sprakel, Joris $e degree supervisor.
720 1 $a Albada, Bauke $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-02B.
790 $a 2157
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31206426