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Synthesis and Characterization of Soft, Stretchable, and Breathable Fibrous Substrates for Bioelectronic Applications /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and Characterization of Soft, Stretchable, and Breathable Fibrous Substrates for Bioelectronic Applications // Joab Stanley Dorsainvil.
作者:	Dorsainvil, Joab Stanley,
面頁冊數:	1 electronic resource (234 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
Contained By:	Dissertations Abstracts International86-12B.
標題:	Biomedical engineering. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32038734
ISBN:	9798280754287

Synthesis and Characterization of Soft, Stretchable, and Breathable Fibrous Substrates for Bioelectronic Applications /
Dorsainvil, Joab Stanley,

Synthesis and Characterization of Soft, Stretchable, and Breathable Fibrous Substrates for Bioelectronic Applications /Joab Stanley Dorsainvil. - 1 electronic resource (234 pages)

Source: Dissertations Abstracts International, Volume: 86-12, Section: B.

Soft material platforms, biomimetic to skin and organs, have recently highlighted bioelectronic technology due to its unique mechanical properties that allow for bending, twisting, folding, and stretching. These film-based substrates and their thin geometry render them capable of conforming to complex topographical structures, which is an essential criterion for maintaining the performance of electronics as a stretchable substrate while preserving tissue layers from scarring due to mechanical mismatch. Although film-based substrates for bioelectronic applications widely dominate the field, film-based devices pose limitations for skin-wearable technology due to their inability to allow the transfer of gases and fluids of the stratum cornea. The stratum cornea, the outermost layer of the epidermis, helps protect regions like the dermis and subcutaneous layer containing millions of veins and arteries. Furthermore, the dermis is where sweat glands reside, which play an essential role in regulating body temperature through the mechanism of sweat perspiration and sweat evaporation. Film-based substrates covering these sweat glands' pores disable the body from regulating the temperature properly, rendering film-based substrates counterproductive in providing accurate diagnoses and treatment for long-term monitoring applications. Contrary to film-based substrates, electrospun nanofibers have received increased attention, with an outlook on their applications in various disciplines. Electrospinning has increasingly gained attention within the last two decades with much focus on utilizing various polymer and fillers for unique mechanical, electrical, biomedical, and chemical substrate applications. Electrospinning is an effective method for drawing viscoelastic liquids into fibers using an electrical field. Fiber diameter, porosity, and alignments can be precisely tailored through the skillful control of process parameters, making it a highly suitable option for many applications. Accordingly, fibrous platforms have recently been demonstrated as advantageous substrates for wearable and bio-integrated devices because of their high surface-to-volume ratio, softness, flexibility, and lightweight nature. Compared to wearable polymeric film-based devices, these nonwoven electrospun fibrous mats exhibit superior breathability because of their porous structure. For soft and stretchable substrates to be actualized for skin-wearable technologies, there is a fundamental need to develop materials suitable for conforming to biological tissues with biomimetic mechanical properties that are applicable as platforms to build complex devices, all while seamlessly coexisting with biological tissue without interfering with their natural processes. The nanofibers' high surface area combined with the 3D architecture allows for free mass transfer, ultimately leading to accurate and reliable device performance while maintaining skin integrity. With fibrous platforms adapted by advanced biodevice technologies to create electrochemical sweat sensors, pressure sensors, biopotential sensing and actuation, and energy harvesting devices, the motivation of this dissertation work is to contribute inexpensive and novel fibrous substrates to seamlessly translate as stretchable, flexible, and breathable substrates for bioelectronic applications contrary to their film-based counterparts. Integrating innovative materials is an imperative step toward achieving a diverse array of substrate types in the evolving realm of fibrous bioelectronics. This drive towards versatility aims to bridge the gap across various scientific disciplines seamlessly. By developing novel fibrous substrates, we unlock the potential for future devices that present both cost-effectiveness in fabrication and material robustness and performance. Moreover, these substrates promise to enable long-term monitoring applications, offering invaluable insights into biological systems without the concern of disrupting biological equilibrium. Embracing this frontier of fibrous substrate innovation aims to redefine the boundaries of bioelectronic devices while moving the research toward a future where seamless device integration and performance reign supreme over current technologies. The criterion of wearable bioelectronic devices being compatible with the skin has become essential for many devices in the field, even with film-based substrates exploring new methods of increasing breathability in thin film substrates. The dissertation work stands out for its creativity and novelty, exploring new research territory with innovative approaches such as (1) merging two essential bioelectronics fields of paper-based bioelectronics and stretchable bioelectronics to join characteristics of both materials in one substrate, (2) manipulating surface chemistry of widely available hydrophobic materials to become applicable for hydrophilic processes while maintaining breathability, and (3) integrating conductive fluidic materials to create alternative electronic configurations for complex fibrous electronics. These advancements could serve as potential substrates for various applications, such as bonding to biological tissue in dry settings akin to epidermal electronics for skin, adhering to tissue in wet environments like implantable devices for organs, or acting as substrates for powering electronics, like biobatteries for intricate bioelectronic devices. This fibrous material is aimed to drive the evolution of wearable electronic devices, facilitating effective material-tissue interactions for prolonged monitoring of biomarkers, thereby enhancing human health.

English

ISBN: 9798280754287Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Electrospinning

Synthesis and Characterization of Soft, Stretchable, and Breathable Fibrous Substrates for Bioelectronic Applications /
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520 $a Soft material platforms, biomimetic to skin and organs, have recently highlighted bioelectronic technology due to its unique mechanical properties that allow for bending, twisting, folding, and stretching. These film-based substrates and their thin geometry render them capable of conforming to complex topographical structures, which is an essential criterion for maintaining the performance of electronics as a stretchable substrate while preserving tissue layers from scarring due to mechanical mismatch. Although film-based substrates for bioelectronic applications widely dominate the field, film-based devices pose limitations for skin-wearable technology due to their inability to allow the transfer of gases and fluids of the stratum cornea. The stratum cornea, the outermost layer of the epidermis, helps protect regions like the dermis and subcutaneous layer containing millions of veins and arteries. Furthermore, the dermis is where sweat glands reside, which play an essential role in regulating body temperature through the mechanism of sweat perspiration and sweat evaporation. Film-based substrates covering these sweat glands' pores disable the body from regulating the temperature properly, rendering film-based substrates counterproductive in providing accurate diagnoses and treatment for long-term monitoring applications. Contrary to film-based substrates, electrospun nanofibers have received increased attention, with an outlook on their applications in various disciplines. Electrospinning has increasingly gained attention within the last two decades with much focus on utilizing various polymer and fillers for unique mechanical, electrical, biomedical, and chemical substrate applications. Electrospinning is an effective method for drawing viscoelastic liquids into fibers using an electrical field. Fiber diameter, porosity, and alignments can be precisely tailored through the skillful control of process parameters, making it a highly suitable option for many applications. Accordingly, fibrous platforms have recently been demonstrated as advantageous substrates for wearable and bio-integrated devices because of their high surface-to-volume ratio, softness, flexibility, and lightweight nature. Compared to wearable polymeric film-based devices, these nonwoven electrospun fibrous mats exhibit superior breathability because of their porous structure. For soft and stretchable substrates to be actualized for skin-wearable technologies, there is a fundamental need to develop materials suitable for conforming to biological tissues with biomimetic mechanical properties that are applicable as platforms to build complex devices, all while seamlessly coexisting with biological tissue without interfering with their natural processes. The nanofibers' high surface area combined with the 3D architecture allows for free mass transfer, ultimately leading to accurate and reliable device performance while maintaining skin integrity. With fibrous platforms adapted by advanced biodevice technologies to create electrochemical sweat sensors, pressure sensors, biopotential sensing and actuation, and energy harvesting devices, the motivation of this dissertation work is to contribute inexpensive and novel fibrous substrates to seamlessly translate as stretchable, flexible, and breathable substrates for bioelectronic applications contrary to their film-based counterparts. Integrating innovative materials is an imperative step toward achieving a diverse array of substrate types in the evolving realm of fibrous bioelectronics. This drive towards versatility aims to bridge the gap across various scientific disciplines seamlessly. By developing novel fibrous substrates, we unlock the potential for future devices that present both cost-effectiveness in fabrication and material robustness and performance. Moreover, these substrates promise to enable long-term monitoring applications, offering invaluable insights into biological systems without the concern of disrupting biological equilibrium. Embracing this frontier of fibrous substrate innovation aims to redefine the boundaries of bioelectronic devices while moving the research toward a future where seamless device integration and performance reign supreme over current technologies. The criterion of wearable bioelectronic devices being compatible with the skin has become essential for many devices in the field, even with film-based substrates exploring new methods of increasing breathability in thin film substrates. The dissertation work stands out for its creativity and novelty, exploring new research territory with innovative approaches such as (1) merging two essential bioelectronics fields of paper-based bioelectronics and stretchable bioelectronics to join characteristics of both materials in one substrate, (2) manipulating surface chemistry of widely available hydrophobic materials to become applicable for hydrophilic processes while maintaining breathability, and (3) integrating conductive fluidic materials to create alternative electronic configurations for complex fibrous electronics. These advancements could serve as potential substrates for various applications, such as bonding to biological tissue in dry settings akin to epidermal electronics for skin, adhering to tissue in wet environments like implantable devices for organs, or acting as substrates for powering electronics, like biobatteries for intricate bioelectronic devices. This fibrous material is aimed to drive the evolution of wearable electronic devices, facilitating effective material-tissue interactions for prolonged monitoring of biomarkers, thereby enhancing human health.
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653 $a Skin
653 $a Fiber diameter
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710 2 $a State University of New York at Binghamton. $b Bioengineering. $e degree granting institution. $3 3825037
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