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Advanced Polymeric Architectures: Fr...

Zhang, Ziwen,

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Advanced Polymeric Architectures: From Molecular Design to Network Functions /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Advanced Polymeric Architectures: From Molecular Design to Network Functions // Ziwen Zhang.
Author:	Zhang, Ziwen,
Description:	1 electronic resource (140 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
Contained By:	Dissertations Abstracts International86-12B.
Subject:	Chemical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32037909
ISBN:	9798280775404

Advanced Polymeric Architectures: From Molecular Design to Network Functions /
Zhang, Ziwen,

Advanced Polymeric Architectures: From Molecular Design to Network Functions /Ziwen Zhang. - 1 electronic resource (140 pages)

Source: Dissertations Abstracts International, Volume: 86-12, Section: B.

Nowadays, novel polymeric materials find widespread applications in advancing biomedical science, structural engineering, and filtration technology. However, the development of multifunctional polymers with enhanced biocompatibility, durability, adaptability, and sustainability remains a significant challenge. This dissertation addresses these challenges by exploring advanced polymeric architectures, from modulating their molecular design to tailoring their polymeric functionalities.The first chapter introduces a Penicillin V (PV)-based polymer-antibiotic conjugate (PAC) as an additive to resin-based restorative dental materials, presenting a novel strategy for imparting sustained antibacterial properties. The enhanced antibacterial performance is expected to improve the longevity of the dental filling materials used for the treatment of the oral cavity. Our findings confirm that such a system exhibits a sustained antibiotic release profile, no noticeable build-up antibiotic resistance, minimal leakage, and no release of cytotoxic byproducts that could inhibit human gingival fibroblast growth. Furthermore, testing against an S. mutans biofilm model demonstrated a significant reduction in bacterial counts, suggesting that PAC-incorporated resin could be effective in reducing the re-incidence of dental caries.In the second chapter, a self-healing and self-reinforceable dynamic crosslinked polymeric network (DCPN) with two types of dynamic bonds (hindered urea bonds, thiourethane bonds) is presented. By enabling catalyst-free conversion of the dynamic hindered urea bonds to dynamic thiourethane bonds, such a self-healing material exhibits enhanced mechanical properties along with time or triggered by elevated temperature. Overall, this work elucidates a new strategy to address the concern of mechanical property deterioration, which restricts the applications of many materials. The research findings of this work can provide helpful guidelines for the future development of innovative self-healing materials with exchangeable multiple kinds of dynamic covalent bonds.The third chapter reviews biodegradable zwitterionic polymers (ZPs) as alternatives to poly(ethylene glycol) (PEG) for biomedical applications. PEG and derived materials have been shown to possess immunogenicity and antigenicity, which severely limit their biomedical efficacy and biocompatibility. In contrast, ZPs are gaining increasing attention due to their excellent hydrophilicity and negligible immunogenicity, offering a range of favorable properties for biomedical applications without causing noticeable long-term in vivo side effects. Accordingly, as emerging PEG alternatives, biodegradable ZPs are promising biomaterials, particularly for drug delivery applications. This work provides a systematic overview of recent studies on biodegradable ZPs in biomedical contexts, covering their structural designs, synthetic strategies, biodegradability, and conjugation with biomedical moieties (such as drugs and proteins). The work demonstrates comprehensive pathways of developing ZP nanostructures and highlights their potentials for advanced drug delivery, aiming to meet sophisticated biomedical needs.The last chapter presents an unpublished collaboration work. Methacryloyl-functionalized crown ethers, including 18-crown-6 methacrylate (18C6-MA), 15-crown-5 methacrylate (15C5-MA), and 12-crown-4 methacrylate (12C4-MA), were synthesized and subsequently polymerized with polyethylene glycol diacrylate (PEGDA) via UV curing to obtain crosslinked thin films. With preserved inherent ring cavities of crown ethers, the resulting polymeric networks possess well-defined nanoporous architectures, which are expected to facilitate selective molecular transportation and may find applications in the separation of gases and metal cations.

English

ISBN: 9798280775404Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

Polymeric materials

Advanced Polymeric Architectures: From Molecular Design to Network Functions /
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500 $a Advisors: Cheng, Chong Committee members: Swihart, Mark; Andreadis, Stylianos.
502 $b Ph.D. $c State University of New York at Buffalo $d 2025.
520 $a Nowadays, novel polymeric materials find widespread applications in advancing biomedical science, structural engineering, and filtration technology. However, the development of multifunctional polymers with enhanced biocompatibility, durability, adaptability, and sustainability remains a significant challenge. This dissertation addresses these challenges by exploring advanced polymeric architectures, from modulating their molecular design to tailoring their polymeric functionalities.The first chapter introduces a Penicillin V (PV)-based polymer-antibiotic conjugate (PAC) as an additive to resin-based restorative dental materials, presenting a novel strategy for imparting sustained antibacterial properties. The enhanced antibacterial performance is expected to improve the longevity of the dental filling materials used for the treatment of the oral cavity. Our findings confirm that such a system exhibits a sustained antibiotic release profile, no noticeable build-up antibiotic resistance, minimal leakage, and no release of cytotoxic byproducts that could inhibit human gingival fibroblast growth. Furthermore, testing against an S. mutans biofilm model demonstrated a significant reduction in bacterial counts, suggesting that PAC-incorporated resin could be effective in reducing the re-incidence of dental caries.In the second chapter, a self-healing and self-reinforceable dynamic crosslinked polymeric network (DCPN) with two types of dynamic bonds (hindered urea bonds, thiourethane bonds) is presented. By enabling catalyst-free conversion of the dynamic hindered urea bonds to dynamic thiourethane bonds, such a self-healing material exhibits enhanced mechanical properties along with time or triggered by elevated temperature. Overall, this work elucidates a new strategy to address the concern of mechanical property deterioration, which restricts the applications of many materials. The research findings of this work can provide helpful guidelines for the future development of innovative self-healing materials with exchangeable multiple kinds of dynamic covalent bonds.The third chapter reviews biodegradable zwitterionic polymers (ZPs) as alternatives to poly(ethylene glycol) (PEG) for biomedical applications. PEG and derived materials have been shown to possess immunogenicity and antigenicity, which severely limit their biomedical efficacy and biocompatibility. In contrast, ZPs are gaining increasing attention due to their excellent hydrophilicity and negligible immunogenicity, offering a range of favorable properties for biomedical applications without causing noticeable long-term in vivo side effects. Accordingly, as emerging PEG alternatives, biodegradable ZPs are promising biomaterials, particularly for drug delivery applications. This work provides a systematic overview of recent studies on biodegradable ZPs in biomedical contexts, covering their structural designs, synthetic strategies, biodegradability, and conjugation with biomedical moieties (such as drugs and proteins). The work demonstrates comprehensive pathways of developing ZP nanostructures and highlights their potentials for advanced drug delivery, aiming to meet sophisticated biomedical needs.The last chapter presents an unpublished collaboration work. Methacryloyl-functionalized crown ethers, including 18-crown-6 methacrylate (18C6-MA), 15-crown-5 methacrylate (15C5-MA), and 12-crown-4 methacrylate (12C4-MA), were synthesized and subsequently polymerized with polyethylene glycol diacrylate (PEGDA) via UV curing to obtain crosslinked thin films. With preserved inherent ring cavities of crown ethers, the resulting polymeric networks possess well-defined nanoporous architectures, which are expected to facilitate selective molecular transportation and may find applications in the separation of gases and metal cations.
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590 $a School code: 0656
650 4 $a Chemical engineering. $3 560457
650 4 $a Biomedical engineering. $3 535387
650 4 $a Polymer chemistry. $3 3173488
653 $a Polymeric materials
653 $a Polymer-antibiotic conjugate
653 $a Dynamic crosslinked polymeric network
690 $a 0542
690 $a 0541
690 $a 0495
710 2 $a State University of New York at Buffalo. $b Chemical and Biological Engineering. $e degree granting institution. $3 3817064
720 1 $a Cheng, Chong $e degree supervisor.
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791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32037909