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Monitoring and Assessment of Vascula...

Maheshwari, Nisha,

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Monitoring and Assessment of Vascular Diseases With Dynamic Optical Spectroscopy and Imaging /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Monitoring and Assessment of Vascular Diseases With Dynamic Optical Spectroscopy and Imaging // Nisha Maheshwari.
Author:	Maheshwari, Nisha,
Description:	1 electronic resource (213 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32002510
ISBN:	9798315764052

Monitoring and Assessment of Vascular Diseases With Dynamic Optical Spectroscopy and Imaging /
Maheshwari, Nisha,

Monitoring and Assessment of Vascular Diseases With Dynamic Optical Spectroscopy and Imaging /Nisha Maheshwari. - 1 electronic resource (213 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

Peripheral arterial disease (PAD) and ischemic stroke are two of the most prevalent vascular diseases globally. PAD has increased by 72% in the last 30 years, now affecting over 200 million people worldwide, and the World Stroke Organization's 2025 report stated that 25% of all people will have a stroke in their lifetime. Despite being large contributors to cardiovascular morbidity and mortality, both diseases are often underdiagnosed in the early stages. Current monitoring and diagnostic methods such as the ankle-brachial index, computed tomographic angiography, and ultrasound, have limitations in sensitivity and applicability, creating large gaps in clinical care.Near-infrared spectroscopy (NIRS) and diffuse optical tomography (DOT) have emerged as promising optical imaging modalities for assessing vascular health. The propagation of light in the NIR wavelength range (650-2500 nm) through biological tissue is well-researched. It has been demonstrated that NIRS and DOT can be used to quantify changes in oxy and deoxyhemoglobin concentrations and derive parameters such as oxygen saturation (StO2) in diseased vessels. This dissertation aims to further assess and validate the use of NIRS and DOT for detecting and monitoring PAD and ischemic stroke.First, I analyzed data from an observational study with a cohort of 95 PAD patients who underwent surgical intervention. Data were acquired using a NIRS system, and I determined the optically derived parameters related to PAD severity and long-term ability of the system to provide physicians with real-time feedback. Based on the insights from this study, I developed a pressure-dependent handheld NIRS probe ("pressure probe") to improve the prediction and assessment of a patient's response to a surgical intervention. Initial testing with the pressure probe established a relationship between pressure applied to tissue and hemodynamic changes in the corresponding tissue. Given the strong correlation between PAD and ischemic stroke, I optimized the NIRS system used in the PAD study for carotid artery monitoring. I conducted a preliminary study with 20 healthy subjects to validate the system's ability to monitor hemodynamics and StO2 in tissues surrounding the carotid artery. In parallel, I developed a DOT system capable of visualizing 3D changes in the carotid artery. Finally, I used software simulations to iterate on the DOT system for the purpose of plaque detection and characterization. It is my hope that the research presented in this dissertation will add to the growing body of evidence supporting the clinical use of NIRS and DOT in vascular disease management. By using these modalities to improve early detection and real-time monitoring, we may be able to improve patient outcomes and make primary and secondary prevention more accessible for all patients.

English

ISBN: 9798315764052Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Diffuse optical tomography

Monitoring and Assessment of Vascular Diseases With Dynamic Optical Spectroscopy and Imaging /
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520 $a Peripheral arterial disease (PAD) and ischemic stroke are two of the most prevalent vascular diseases globally. PAD has increased by 72% in the last 30 years, now affecting over 200 million people worldwide, and the World Stroke Organization's 2025 report stated that 25% of all people will have a stroke in their lifetime. Despite being large contributors to cardiovascular morbidity and mortality, both diseases are often underdiagnosed in the early stages. Current monitoring and diagnostic methods such as the ankle-brachial index, computed tomographic angiography, and ultrasound, have limitations in sensitivity and applicability, creating large gaps in clinical care.Near-infrared spectroscopy (NIRS) and diffuse optical tomography (DOT) have emerged as promising optical imaging modalities for assessing vascular health. The propagation of light in the NIR wavelength range (650-2500 nm) through biological tissue is well-researched. It has been demonstrated that NIRS and DOT can be used to quantify changes in oxy and deoxyhemoglobin concentrations and derive parameters such as oxygen saturation (StO2) in diseased vessels. This dissertation aims to further assess and validate the use of NIRS and DOT for detecting and monitoring PAD and ischemic stroke.First, I analyzed data from an observational study with a cohort of 95 PAD patients who underwent surgical intervention. Data were acquired using a NIRS system, and I determined the optically derived parameters related to PAD severity and long-term ability of the system to provide physicians with real-time feedback. Based on the insights from this study, I developed a pressure-dependent handheld NIRS probe ("pressure probe") to improve the prediction and assessment of a patient's response to a surgical intervention. Initial testing with the pressure probe established a relationship between pressure applied to tissue and hemodynamic changes in the corresponding tissue. Given the strong correlation between PAD and ischemic stroke, I optimized the NIRS system used in the PAD study for carotid artery monitoring. I conducted a preliminary study with 20 healthy subjects to validate the system's ability to monitor hemodynamics and StO2 in tissues surrounding the carotid artery. In parallel, I developed a DOT system capable of visualizing 3D changes in the carotid artery. Finally, I used software simulations to iterate on the DOT system for the purpose of plaque detection and characterization. It is my hope that the research presented in this dissertation will add to the growing body of evidence supporting the clinical use of NIRS and DOT in vascular disease management. By using these modalities to improve early detection and real-time monitoring, we may be able to improve patient outcomes and make primary and secondary prevention more accessible for all patients.
546 $a English
590 $a School code: 1988
650 4 $a Biomedical engineering. $3 535387
650 4 $a Bioengineering. $3 657580
653 $a Diffuse optical tomography
653 $a Peripheral arterial disease
653 $a Near-infrared spectroscopy
653 $a Ischemic stroke
653 $a DOT system
690 $a 0541
690 $a 0769
690 $a 0202
710 2 $a New York University Tandon School of Engineering. $b Biomedical Engineering. $e degree granting institution. $3 3825021
720 1 $a Hielscher, Andreas H. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-11B.
790 $a 1988
791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32002510