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Prostate Specific Membrane Antigen A...

Shirke, Aditi Ashish,

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Prostate Specific Membrane Antigen Applications as a Biomarker for Prostate Cancer and Breast Cancer /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Prostate Specific Membrane Antigen Applications as a Biomarker for Prostate Cancer and Breast Cancer // Aditi Ashish Shirke.
Author:	Shirke, Aditi Ashish,
Description:	1 electronic resource (340 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-08, Section: B.
Contained By:	Dissertations Abstracts International86-08B.
Subject:	Oncology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31892098
ISBN:	9798302859853

Prostate Specific Membrane Antigen Applications as a Biomarker for Prostate Cancer and Breast Cancer /
Shirke, Aditi Ashish,

Prostate Specific Membrane Antigen Applications as a Biomarker for Prostate Cancer and Breast Cancer /Aditi Ashish Shirke. - 1 electronic resource (340 pages)

Source: Dissertations Abstracts International, Volume: 86-08, Section: B.

Due to recent advancements in the field of cancer imaging and diagnostic techniques, most solid human cancers are diagnosed at earlier stages while the cancer is still localized to a primary tumor site. For this reason, surgery remains the cornerstone of curative treatment with the primary objective of surgical intervention being the complete removal of the tumor, aiming to eliminate cancerous tissues. Ideally, this goal is achieved in a single surgical procedure, ensuring no residual malignant tissue remains. However, achieving complete resection can be challenging, particularly in traditional surgeries where surgeons primarily rely on gross visual inspection and tactile feedback to identify and remove the tumor. This increases the risk of leaving behind microscopic cancer cells that are not visible or palpable during the procedure. As a result, there is a significant risk of Positive Surgical Margins (PSMs), where cancer cells are present at the edge of the resected tissue. PSMs are a critical concern because they often result in tumor recurrence and necessitate additional treatments including adjuvant therapies, such as radiation therapy, chemotherapy and so on. These therapies, while essential for reducing the risk of recurrence, substantially increase the overall cost and complexity of treatment and add to the physical and emotional burden on patients, prolonging the recovery process and potentially impacting their quality of life. The challenge of achieving complete tumor resection underscores the need for improved surgical technologies and adjunct treatments that can enhance the live visualization of tumor removal and simultaneously treat the remaining tissues to reduce tumor recurrence and improve overall survival. To address these challenges, this research aims to enhance treatment strategies for prostate cancer (PCa) through innovative theranostic approaches utilizing Prostate-Specific Membrane Antigen (PSMA) as a key biomarker. PSMA is notably overexpressed in PCa cells, prompting our investigation into the efficacy of combining Fluorescence Image Guided Surgery (FIGS) with Photodynamic Therapy (PDT) using the theranostic agent PSMA-1-Pc413. By improving live tumor visualization and applying PDT post-surgery to target residual tissues, we successfully enhanced surgical outcomes and overall survival rates in murine models. Additionally, we explored the synergistic effects of combining PDT with chemotherapy using the PSMA-1-MMAE-Pc413 agent, demonstrating significant improvements in tumor eradication and survival.Furthermore, PSMA overexpression is also observed in various solid tumors, including breast cancer, where it is localized on both tumor cells and neovasculature. We confirmed PSMA gene expression in human breast cancer using transcriptomic data from the UCSC Xena database and further characterized PSMA expression in primary tumors and lung metastases in a syngeneic murine breast cancer model. This provided valuable insights into the potential for targeted therapies. Finally, we evaluated the effectiveness of PSMA-1-Pc413 in triple-negative breast cancer (TNBC) tumors, focusing on its ability to target PSMA-expressing neovasculature and applying PDT as an adjuvant therapy. Our findings indicated that this approach effectively reduces tumor growth and lung metastasis formation in mice.This research collectively provided an approach to refine targeted therapeutic approaches, improve treatment precision, and advance clinical outcomes, through the use of PSMA as a biomarker. These studies additionally highlight the potential for PSMA to be used as a biomarker for diagnostic and therapeutic applications in non-prostatic cancers such as BCa.

English

ISBN: 9798302859853Subjects--Topical Terms:

751006
Oncology.
Subjects--Index Terms:

Cancer imaging

Prostate Specific Membrane Antigen Applications as a Biomarker for Prostate Cancer and Breast Cancer /
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