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The Applications of Photo-Mediated U...

Wang, Mingyang,

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The Applications of Photo-Mediated Ultrasound Therapy in Vascular Diseases /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Applications of Photo-Mediated Ultrasound Therapy in Vascular Diseases // Mingyang Wang.
作者:	Wang, Mingyang,
面頁冊數:	1 electronic resource (112 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-07, Section: A.
Contained By:	Dissertations Abstracts International86-07A.
標題:	Biomedical engineering. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31871488
ISBN:	9798346892137

The Applications of Photo-Mediated Ultrasound Therapy in Vascular Diseases /
Wang, Mingyang,

The Applications of Photo-Mediated Ultrasound Therapy in Vascular Diseases /Mingyang Wang. - 1 electronic resource (112 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: A.

The formation of new blood vessels can be associated with various pathological conditions requiring clinical interventions, including blinding eye diseases, tumor metastasis, and skin capillary malformation. We developed a hybrid cavitation-based anti-vascular technique using synchronized nanosecond laser pulses and ultrasound bursts, termed photo-mediated ultrasound therapy (PUT). By precisely controlling the spatiotemporal synchronization between the nanosecond laser pulse induced photoacoustic waves and the second source of ultrasound bursts, selective cavitation can be induced within blood vessel. The resulting shear stress, circumferential stress, and microjets from micro-cavitation led to vasocontraction and blood clot formation for therapeutic effect noninvasively.This dissertation focuses on preclinical studies on the applications of PUT on two types of vascular diseases: capillary vascular malformation with overgrowth in dermatology and choroidal neovascularization in ophthalmology. A common methodological pipeline was employed for both applications. First, a fully integrated prototype system including laser system, focused ultrasound system, and additional optomechanical design was developed to achieve efficient coupling of laser and ultrasound into the vascular lesions of in vivo animal models. Spatiotemporal synchronization between photoacoustic and focused ultrasound waves was achieved through designing precise timing diagrams. Secondly, various optical imaging modalities, including optical coherence tomography and fundus microscopy, were self-built or upgraded from off-shelf equipment to assess therapy efficacy both intraoperatively and postoperatively. Finally, immunohistochemistry and histopathological analyses were conducted to validate treatment outcomes and serve as the ground truth for evaluations.In addition to the non-invasive, non-thermal, and high-precision nature of PUT, the results of this study highlight its substantial potential to address current clinical limitations. In the in vivo chicken wattle hypervascularity model, PUT effectively treated vasculature up to a depth of 3 mm in dermis. This is achieved by leveraging ultrasound's good penetration capabilities, thus bypassing the 1.5 mm depth limitation of pulsed dye laser treatments commonly used in dermatology clinics. In the in vivo rabbit choroidal neovascularization model, PUT successfully stopped vascular leakage without significantly damaging neurosensory tissue, using a laser fluence of 85 mJ/cm² at 1064 nm. This is in contrast to the 50 J/cm² at 689 nm required for standard photodynamic therapy in ophthalmology clinics. These findings underscore PUT's translational potential for clinical interventions in treating vascular diseases in both dermatology and ophthalmology.

English

ISBN: 9798346892137Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Cavitation

The Applications of Photo-Mediated Ultrasound Therapy in Vascular Diseases /
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520 $a The formation of new blood vessels can be associated with various pathological conditions requiring clinical interventions, including blinding eye diseases, tumor metastasis, and skin capillary malformation. We developed a hybrid cavitation-based anti-vascular technique using synchronized nanosecond laser pulses and ultrasound bursts, termed photo-mediated ultrasound therapy (PUT). By precisely controlling the spatiotemporal synchronization between the nanosecond laser pulse induced photoacoustic waves and the second source of ultrasound bursts, selective cavitation can be induced within blood vessel. The resulting shear stress, circumferential stress, and microjets from micro-cavitation led to vasocontraction and blood clot formation for therapeutic effect noninvasively.This dissertation focuses on preclinical studies on the applications of PUT on two types of vascular diseases: capillary vascular malformation with overgrowth in dermatology and choroidal neovascularization in ophthalmology. A common methodological pipeline was employed for both applications. First, a fully integrated prototype system including laser system, focused ultrasound system, and additional optomechanical design was developed to achieve efficient coupling of laser and ultrasound into the vascular lesions of in vivo animal models. Spatiotemporal synchronization between photoacoustic and focused ultrasound waves was achieved through designing precise timing diagrams. Secondly, various optical imaging modalities, including optical coherence tomography and fundus microscopy, were self-built or upgraded from off-shelf equipment to assess therapy efficacy both intraoperatively and postoperatively. Finally, immunohistochemistry and histopathological analyses were conducted to validate treatment outcomes and serve as the ground truth for evaluations.In addition to the non-invasive, non-thermal, and high-precision nature of PUT, the results of this study highlight its substantial potential to address current clinical limitations. In the in vivo chicken wattle hypervascularity model, PUT effectively treated vasculature up to a depth of 3 mm in dermis. This is achieved by leveraging ultrasound's good penetration capabilities, thus bypassing the 1.5 mm depth limitation of pulsed dye laser treatments commonly used in dermatology clinics. In the in vivo rabbit choroidal neovascularization model, PUT successfully stopped vascular leakage without significantly damaging neurosensory tissue, using a laser fluence of 85 mJ/cm² at 1064 nm. This is in contrast to the 50 J/cm² at 689 nm required for standard photodynamic therapy in ophthalmology clinics. These findings underscore PUT's translational potential for clinical interventions in treating vascular diseases in both dermatology and ophthalmology.
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650 4 $a Therapy. $3 3343697
653 $a Cavitation
653 $a Port-wine stains
653 $a Age-related macular degeneration
653 $a Laser pulses
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653 $a Optical imaging
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