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Broadening LiDAR's Applications Acro...

Zheng, Zipei,

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Broadening LiDAR's Applications Across Fields: An Exploration on Biomedical Imaging /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Broadening LiDAR's Applications Across Fields: An Exploration on Biomedical Imaging // Zipei Zheng.
Author:	Zheng, Zipei,
Description:	1 electronic resource (117 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
Subject:	Physics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31845655
ISBN:	9798315740216

Broadening LiDAR's Applications Across Fields: An Exploration on Biomedical Imaging /
Zheng, Zipei,

Broadening LiDAR's Applications Across Fields: An Exploration on Biomedical Imaging /Zipei Zheng. - 1 electronic resource (117 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

Since its inception in the early 1960s, Light Detection and Ranging (LiDAR) has rapidly advanced, demonstrating its capabilities across various fields. On the other hand, elastography has become an important tool in biomedical diagnostics for differentiating between healthy and cancerous tissues. To date, no research has combined LiDAR technology with elastography; this dissertation presents the first successful attempt to explore this uncharted domain.Initially, I verified that materials with different elasticities exhibit distinct responses to acoustic excitation. For example, when low-frequency sound waves are applied to an agar phantom, soft agar exhibits a stronger response than hard agar. This response is captured as varying oscillation amplitudes on the reflected photon counting histogram, using single-photon counting LiDAR. With the aid of nonlinear optical frequency conversion, ambient light is effectively rejected, allowing for the detection of photon count oscillations with minimal noise. By performing a Fourier transform on the oscillations, I observed sharp peaks in the corresponding spectrum, enabling the calculation of the peak-to-noise ratio (PNR) at the sound wave's frequency. The PNR value is higher in the soft agar region and lower in the hard agar region, providing a reliable basis for constructing elasticity-based images in two dimensions.I then extended the photon-counting elastography technique to deep tissue applications. My experiments show that photons can penetrate tissue phantoms, and by separately detecting backscattered photons from different layers based on their time of flight, three-dimensional elastograms can be reconstructed. Using 9.6 mW infrared laser at 1554 nm, I obtained a 3D elasticity-contrast image of an agar phantom placed behind a titanium dioxide scattering medium with a single-path optical depth of 3.27 OD. This result represents a novel capability in biomedical imaging, with significant potential for non-invasive, in vivo optical measurement and deep-tissue imaging.

English

ISBN: 9798315740216Subjects--Topical Terms:

516296
Physics.
Subjects--Index Terms:

Biomedical imaging

Broadening LiDAR's Applications Across Fields: An Exploration on Biomedical Imaging /
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520 $a Since its inception in the early 1960s, Light Detection and Ranging (LiDAR) has rapidly advanced, demonstrating its capabilities across various fields. On the other hand, elastography has become an important tool in biomedical diagnostics for differentiating between healthy and cancerous tissues. To date, no research has combined LiDAR technology with elastography; this dissertation presents the first successful attempt to explore this uncharted domain.Initially, I verified that materials with different elasticities exhibit distinct responses to acoustic excitation. For example, when low-frequency sound waves are applied to an agar phantom, soft agar exhibits a stronger response than hard agar. This response is captured as varying oscillation amplitudes on the reflected photon counting histogram, using single-photon counting LiDAR. With the aid of nonlinear optical frequency conversion, ambient light is effectively rejected, allowing for the detection of photon count oscillations with minimal noise. By performing a Fourier transform on the oscillations, I observed sharp peaks in the corresponding spectrum, enabling the calculation of the peak-to-noise ratio (PNR) at the sound wave's frequency. The PNR value is higher in the soft agar region and lower in the hard agar region, providing a reliable basis for constructing elasticity-based images in two dimensions.I then extended the photon-counting elastography technique to deep tissue applications. My experiments show that photons can penetrate tissue phantoms, and by separately detecting backscattered photons from different layers based on their time of flight, three-dimensional elastograms can be reconstructed. Using 9.6 mW infrared laser at 1554 nm, I obtained a 3D elasticity-contrast image of an agar phantom placed behind a titanium dioxide scattering medium with a single-path optical depth of 3.27 OD. This result represents a novel capability in biomedical imaging, with significant potential for non-invasive, in vivo optical measurement and deep-tissue imaging.
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