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Development of Endovascular Devices ...

Oliver, Alexander Andrew,

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Development of Endovascular Devices Using Progressive Materials: In Vivo Evaluations of Bioresorbable and Magnetic Cell Capture Enabling Devices /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of Endovascular Devices Using Progressive Materials: In Vivo Evaluations of Bioresorbable and Magnetic Cell Capture Enabling Devices // Alexander Andrew Oliver.
Author:	Oliver, Alexander Andrew,
Description:	1 electronic resource (331 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31769470
ISBN:	9798302181497

Development of Endovascular Devices Using Progressive Materials: In Vivo Evaluations of Bioresorbable and Magnetic Cell Capture Enabling Devices /
Oliver, Alexander Andrew,

Development of Endovascular Devices Using Progressive Materials: In Vivo Evaluations of Bioresorbable and Magnetic Cell Capture Enabling Devices /Alexander Andrew Oliver. - 1 electronic resource (331 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Cardiovascular disease is the leading cause of death in the US. These conditions commonly present as lesions of the blood vessels that inhibit their ability to deliver blood to downstream tissues. Endovascular treatment approaches have rapidly grown in clinical use and application. In this approach, vascular access is gained in a peripheral blood vessel and a catheter is navigated through the vasculature to the lesion under X-ray guidance. An endovascular device, such as a stent, valve, or coil, is deployed through the catheter to treat the lesion. Relative to open surgery, the endovascular approach generally reduces pain, recovery time, and risk of periprocedural complication.While endovascular devices have become a gold standard approach for treating common vascular pathologies, there are still several associated complications such as device induced thrombosis and stenosis. Endovascular devices are typically constructed from materials selected to optimize deployability and mechanical function. These materials are considered tolerable and advertised as inert in the blood vessel.This thesis explores the concept of constructing endovascular devices from materials selected with the primary objective of improving the biological response, without compromising deployability and mechanical function. In Part 1, bioresorbable flow diverters are investigated for the treatment of intracranial aneurysms. These devices aim to serve their transient function of healing the aneurysm prior to safely dissolving, mitigating complications associated with the permanent presence of conventional flow diverters. Devices were prototyped from multiple materials and their strength, flow diversion functionality, and MRI safety were demonstrated in benchtop experiments. Iron-based bioresorbable flow diverters were evaluated in the rabbit elastase induced aneurysm model. These experiments demonstrated the selected materials were biocompatible but degraded too rapidly to effectively treat the aneurysms.In Part 2, an approach to magnetically capture cells to the surface of endovascular devices to promote healing is investigated. Magnetic stent grafts were used to capture autologous blood outgrowth endothelial cells in a porcine carotid artery pseudoaneurysm model. Magnetic venous stents were used to capture autologous mesenchymal stem cells in a rabbit iliac vein model. Both approaches demonstrated evidence of magnetic cell capture and improved healing relative to non-magnetic control devices in vivo.

English

ISBN: 9798302181497Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Biodegradable

Development of Endovascular Devices Using Progressive Materials: In Vivo Evaluations of Bioresorbable and Magnetic Cell Capture Enabling Devices /
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520 $a Cardiovascular disease is the leading cause of death in the US. These conditions commonly present as lesions of the blood vessels that inhibit their ability to deliver blood to downstream tissues. Endovascular treatment approaches have rapidly grown in clinical use and application. In this approach, vascular access is gained in a peripheral blood vessel and a catheter is navigated through the vasculature to the lesion under X-ray guidance. An endovascular device, such as a stent, valve, or coil, is deployed through the catheter to treat the lesion. Relative to open surgery, the endovascular approach generally reduces pain, recovery time, and risk of periprocedural complication.While endovascular devices have become a gold standard approach for treating common vascular pathologies, there are still several associated complications such as device induced thrombosis and stenosis. Endovascular devices are typically constructed from materials selected to optimize deployability and mechanical function. These materials are considered tolerable and advertised as inert in the blood vessel.This thesis explores the concept of constructing endovascular devices from materials selected with the primary objective of improving the biological response, without compromising deployability and mechanical function. In Part 1, bioresorbable flow diverters are investigated for the treatment of intracranial aneurysms. These devices aim to serve their transient function of healing the aneurysm prior to safely dissolving, mitigating complications associated with the permanent presence of conventional flow diverters. Devices were prototyped from multiple materials and their strength, flow diversion functionality, and MRI safety were demonstrated in benchtop experiments. Iron-based bioresorbable flow diverters were evaluated in the rabbit elastase induced aneurysm model. These experiments demonstrated the selected materials were biocompatible but degraded too rapidly to effectively treat the aneurysms.In Part 2, an approach to magnetically capture cells to the surface of endovascular devices to promote healing is investigated. Magnetic stent grafts were used to capture autologous blood outgrowth endothelial cells in a porcine carotid artery pseudoaneurysm model. Magnetic venous stents were used to capture autologous mesenchymal stem cells in a rabbit iliac vein model. Both approaches demonstrated evidence of magnetic cell capture and improved healing relative to non-magnetic control devices in vivo.
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650 4 $a Pathology. $3 643180
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650 4 $a Surgery. $3 707153
653 $a Biodegradable
653 $a Bioresorbable flow diverters
653 $a Endothelialization
653 $a Endovascular devices
653 $a Magnetic cell capture
653 $a Magnetic stent grafts
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710 2 $a College of Medicine - Mayo Clinic. $b Biomedical Engineering. $e degree granting institution. $3 3824891
720 1 $a Kallmes, David F. $e degree supervisor.
720 1 $a Dragomir-Daescu, Dan $e degree supervisor.
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