東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Endogenous and Exogenous Control of ...

Flowers, Marcus E. H.,

FindBook

Google Book

Amazon

博客來

Endogenous and Exogenous Control of Polymers for Spatiotemporally Defined Drug Delivery /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Endogenous and Exogenous Control of Polymers for Spatiotemporally Defined Drug Delivery // Marcus E. H Flowers.
作者:	Flowers, Marcus E. H.,
面頁冊數:	1 electronic resource (191 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-09, Section: B.
Contained By:	Dissertations Abstracts International86-09B.
標題:	Biomedical engineering. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31769333
ISBN:	9798310147669

Endogenous and Exogenous Control of Polymers for Spatiotemporally Defined Drug Delivery /
Flowers, Marcus E. H.,

Endogenous and Exogenous Control of Polymers for Spatiotemporally Defined Drug Delivery /Marcus E. H Flowers. - 1 electronic resource (191 pages)

Source: Dissertations Abstracts International, Volume: 86-09, Section: B.

Polymeric 'smart drug delivery systems' respond to external and environmental stimuli to modulate drug release at the right time and in the right place. Here I present several polymer systems to overcome challenges in spatiotemporal control of drug delivery. First, a novel acid-labile liquid polymer responsive to endogenous pH conditions was synthesized and characterized for releasing poorly soluble drugs as an injectable depot, a photo-crosslinked implantable matrix, temporarily stable nanodroplets and stable nanogels. Second, two acid-labile biodegradable liquid polymers were investigated for pH-responsive intracellular delivery of the immunomodulator R848 (or Resiquimod), a poorly soluble adjuvant for a melanoma vaccine. Third, nanodroplets of one of the liquid polymers were embedded in mucoadhesive wafers and were evaluated for spatially defined drug delivery to engineered tissues. Lastly, exogenously controlled drug release was demonstrated using a novel gold-coated hydrogel and focused ultrasound. Together, these studies have presented new biomaterial systems as versatile tools for controlled drug delivery with potential applications in immunotherapy and tissue engineering.

English

ISBN: 9798310147669Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Biomaterials

Endogenous and Exogenous Control of Polymers for Spatiotemporally Defined Drug Delivery /
LDR:02672nmm a22004453i 4500 001 2434786
005 20251001062524.5
006 m o d
007 cr|nu||||||||
008 261011s2025 miu||||||m |||||||eng d
020 $a 9798310147669
035 $a (MiAaPQD)AAI31769333
035 $a AAI31769333
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Flowers, Marcus E. H., $e author. $3 3824885
245 1 0 $a Endogenous and Exogenous Control of Polymers for Spatiotemporally Defined Drug Delivery / $c Marcus E. H Flowers.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2025
300 $a 1 electronic resource (191 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-09, Section: B.
500 $a Advisors: Wang, Chun; Ogle, Brenda Committee members: Shen, Wei; Siegel, Ronald; Odde, David.
502 $b Ph.D. $c University of Minnesota $d 2025.
520 $a Polymeric 'smart drug delivery systems' respond to external and environmental stimuli to modulate drug release at the right time and in the right place. Here I present several polymer systems to overcome challenges in spatiotemporal control of drug delivery. First, a novel acid-labile liquid polymer responsive to endogenous pH conditions was synthesized and characterized for releasing poorly soluble drugs as an injectable depot, a photo-crosslinked implantable matrix, temporarily stable nanodroplets and stable nanogels. Second, two acid-labile biodegradable liquid polymers were investigated for pH-responsive intracellular delivery of the immunomodulator R848 (or Resiquimod), a poorly soluble adjuvant for a melanoma vaccine. Third, nanodroplets of one of the liquid polymers were embedded in mucoadhesive wafers and were evaluated for spatially defined drug delivery to engineered tissues. Lastly, exogenously controlled drug release was demonstrated using a novel gold-coated hydrogel and focused ultrasound. Together, these studies have presented new biomaterial systems as versatile tools for controlled drug delivery with potential applications in immunotherapy and tissue engineering.
546 $a English
590 $a School code: 0130
650 4 $a Biomedical engineering. $3 535387
650 4 $a Oncology. $3 751006
650 4 $a Pharmaceutical sciences. $3 3173021
653 $a Biomaterials
653 $a Cancer
653 $a Drug delivery
653 $a Polymers
653 $a Stem cells
690 $a 0541
690 $a 0992
690 $a 0572
710 2 $a University of Minnesota. $b Biomedical Engineering. $e degree granting institution. $3 3824886
720 1 $a Wang, Chun $e degree supervisor.
720 1 $a Ogle, Brenda $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-09B.
790 $a 0130
791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31769333