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Implantable Devices With Mechanical ...

Kight, Ali,

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Implantable Devices With Mechanical Intelligent Implantable Devices for Heart Failure Therapy /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Implantable Devices With Mechanical Intelligent Implantable Devices for Heart Failure Therapy // Ali Kight.
Author:	Kight, Ali,
Description:	1 electronic resource (200 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
Subject:	Deformation. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31821855
ISBN:	9798302377982

Implantable Devices With Mechanical Intelligent Implantable Devices for Heart Failure Therapy /
Kight, Ali,

Implantable Devices With Mechanical Intelligent Implantable Devices for Heart Failure Therapy /Ali Kight. - 1 electronic resource (200 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

Heart failure (HF) remains a formidable challenge in modern healthcare, with rising mortality rates despite technological advancements. Ventricular remodeling, driven by abnormal myocardial loading, underlies HF progression, instigating a vicious feedback loop of progressive deterioration. Motivated by the need for proactive therapeutic interventions, this thesis explores the development of implantable devices aimed at moderating biomechanical environments to prevent remodeling. Drawing inspiration from Mechanical Intelligence (MI), novel devices were engineered across HF stages.This thesis introduces DynaRing, a biomimetic annuloplasty ring enhancing mitral valve repair, featuring variable stiffness segments for dynamic stability. Results show that DynaRing exhibits improved dynamics compared to clinical gold standards, offering promising outcomes for mitral valve repair. In a second application, this work addresses advanced stage disease, presenting RVEX, an elastic sleeve supporting the right ventricle post-LVAD implantation. RVEX leverages auxetic mechanical metamaterial structures for regional tuning of directional compliance that enables healthy deformation patterns. Modeling demonstrates that RVEX restores biomechanics and mitigates RV dilation, indicating its potential for improving outcomes in right ventricular support.Beyond mechanical support, this thesis explores continuous myocardial strain sensing as a way to detect issues and intervene early, to provide proactive interventions. Large-deformation strain sensing that does not impede the heart's motion is a formidable engineering challenge. This work proposes a novel approach with high-cycle durability. This approach is expanded upon through the development of VITALS, an implantable sensor network for comprehensive cardiac monitoring, showcasing multimaterial fibrosis mitigation and multiaxial sensing through selective patterning and orientation of the novel strain sensor. A series of pre-clinical evaluations demonstrate VITALS' ability to detect clinically relevant events and correlate to clinical gold-standard measurements.This thesis includes a case study on the health-economic benefit of RVEX, a presentation of a commercialization strategy for VITALS, and a technical exploration of implantable strain sensors. In conclusion, this research has facilitated the creation of multiple implantable devices, enabled by a clinical needs-driven design approach, that also takes into account the biomechanical environment, representing a significant stride towards more enduring interventions capable of disrupting the relentless cycle of heart failure through the prevention of remodeling.

English

ISBN: 9798302377982Subjects--Topical Terms:

3267001
Deformation.

Implantable Devices With Mechanical Intelligent Implantable Devices for Heart Failure Therapy /
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520 $a Heart failure (HF) remains a formidable challenge in modern healthcare, with rising mortality rates despite technological advancements. Ventricular remodeling, driven by abnormal myocardial loading, underlies HF progression, instigating a vicious feedback loop of progressive deterioration. Motivated by the need for proactive therapeutic interventions, this thesis explores the development of implantable devices aimed at moderating biomechanical environments to prevent remodeling. Drawing inspiration from Mechanical Intelligence (MI), novel devices were engineered across HF stages.This thesis introduces DynaRing, a biomimetic annuloplasty ring enhancing mitral valve repair, featuring variable stiffness segments for dynamic stability. Results show that DynaRing exhibits improved dynamics compared to clinical gold standards, offering promising outcomes for mitral valve repair. In a second application, this work addresses advanced stage disease, presenting RVEX, an elastic sleeve supporting the right ventricle post-LVAD implantation. RVEX leverages auxetic mechanical metamaterial structures for regional tuning of directional compliance that enables healthy deformation patterns. Modeling demonstrates that RVEX restores biomechanics and mitigates RV dilation, indicating its potential for improving outcomes in right ventricular support.Beyond mechanical support, this thesis explores continuous myocardial strain sensing as a way to detect issues and intervene early, to provide proactive interventions. Large-deformation strain sensing that does not impede the heart's motion is a formidable engineering challenge. This work proposes a novel approach with high-cycle durability. This approach is expanded upon through the development of VITALS, an implantable sensor network for comprehensive cardiac monitoring, showcasing multimaterial fibrosis mitigation and multiaxial sensing through selective patterning and orientation of the novel strain sensor. A series of pre-clinical evaluations demonstrate VITALS' ability to detect clinically relevant events and correlate to clinical gold-standard measurements.This thesis includes a case study on the health-economic benefit of RVEX, a presentation of a commercialization strategy for VITALS, and a technical exploration of implantable strain sensors. In conclusion, this research has facilitated the creation of multiple implantable devices, enabled by a clinical needs-driven design approach, that also takes into account the biomechanical environment, representing a significant stride towards more enduring interventions capable of disrupting the relentless cycle of heart failure through the prevention of remodeling.
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