東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Csp2-csp3 Bond Formation by Rutheniu...

Wheatley, Matthew,

Linked to FindBook

Google Book

Amazon

博客來

Csp2-csp3 Bond Formation by Ruthenium-Catalysed C-H Activation /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Csp2-csp3 Bond Formation by Ruthenium-Catalysed C-H Activation // Matthew Wheatley.
Author:	Wheatley, Matthew,
Description:	1 electronic resource (252 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-10, Section: B.
Contained By:	Dissertations Abstracts International83-10B.
Subject:	Metals. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29051717
ISBN:	9798209937609

Csp2-csp3 Bond Formation by Ruthenium-Catalysed C-H Activation /
Wheatley, Matthew,

Csp2-csp3 Bond Formation by Ruthenium-Catalysed C-H Activation /Matthew Wheatley. - 1 electronic resource (252 pages)

Source: Dissertations Abstracts International, Volume: 83-10, Section: B.

The synthesis of Csp2-Csp3 bonds is one of the most synthetically relevant transformations in organic synthesis. Classical methods, such as Friedel-Crafts alkylation chemistry, remain powerful and industrially relevant techniques. In spite of this, they have significant limitations such as the requirement for strong Lewis acids. Transition metal catalysis has become indispensable for the synthesis of Csp2-Csp3 bonds over the last 20 years, with cross-coupling chemistry and more recently photoredox alkylation of arenes becoming commonplace in the literature.C-H activation is among the most powerful and sustainable of the modern synthetic organic chemistry tools available to practitioners. However, several limitations with the field remain and transformations are often performed under harsh conditions and can lead to mixtures of products. Disclosed herein are two mild and regioselective Csp2-Csp3 bond forming reactions achieved through ruthenium-catalysed C-H activation.Chapter 2 focuses on the ruthenium-catalysed alkylation of arenes with secondary alkyl bromides. The electron-rich nature of the key catalytic intermediate enables a regiochemical outcome that had not been observed in ruthenium catalysis at the time of publication. Again, this reaction was demonstrated to be synthetically useful by showcasing many examples of late-stage diversification of pharmaceutical compounds.Chapter 3 focuses on the ruthenium-catalysed alkylation of arenes with primary alkyl bromides. The mild conditions enabled by the cyclometallated pre-catalyst RuBnN are ultimately responsible for the broad scope, including late-stage alkylation of pharmaceuticals. Detailed mechanistic studies were carried out in order to ascertain key features of the reaction.

English

ISBN: 9798209937609Subjects--Topical Terms:

601053
Metals.

Csp2-csp3 Bond Formation by Ruthenium-Catalysed C-H Activation /
LDR:03128nmm a22003973i 4500 001 2434001
005 20250905091323.5
006 m o d
007 cr|nu||||||||
008 261011s2021 miu||||||m |||||||eng d
020 $a 9798209937609
035 $a (MiAaPQD)AAI29051717
035 $a (MiAaPQD)Manchester_UK07820fb0-752b-4daa-ba98-3913d149aeea
035 $a AAI29051717
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Wheatley, Matthew, $e author. $3 3823831
245 1 0 $a Csp2-csp3 Bond Formation by Ruthenium-Catalysed C-H Activation / $c Matthew Wheatley.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 1 electronic resource (252 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 83-10, Section: B.
500 $a Advisors: Amat, Jorge Bures; Larrosa, Igor.
502 $b Ph.D. $c The University of Manchester (United Kingdom) $d 2021.
520 $a The synthesis of Csp2-Csp3 bonds is one of the most synthetically relevant transformations in organic synthesis. Classical methods, such as Friedel-Crafts alkylation chemistry, remain powerful and industrially relevant techniques. In spite of this, they have significant limitations such as the requirement for strong Lewis acids. Transition metal catalysis has become indispensable for the synthesis of Csp2-Csp3 bonds over the last 20 years, with cross-coupling chemistry and more recently photoredox alkylation of arenes becoming commonplace in the literature.C-H activation is among the most powerful and sustainable of the modern synthetic organic chemistry tools available to practitioners. However, several limitations with the field remain and transformations are often performed under harsh conditions and can lead to mixtures of products. Disclosed herein are two mild and regioselective Csp2-Csp3 bond forming reactions achieved through ruthenium-catalysed C-H activation.Chapter 2 focuses on the ruthenium-catalysed alkylation of arenes with secondary alkyl bromides. The electron-rich nature of the key catalytic intermediate enables a regiochemical outcome that had not been observed in ruthenium catalysis at the time of publication. Again, this reaction was demonstrated to be synthetically useful by showcasing many examples of late-stage diversification of pharmaceutical compounds.Chapter 3 focuses on the ruthenium-catalysed alkylation of arenes with primary alkyl bromides. The mild conditions enabled by the cyclometallated pre-catalyst RuBnN are ultimately responsible for the broad scope, including late-stage alkylation of pharmaceuticals. Detailed mechanistic studies were carried out in order to ascertain key features of the reaction.
546 $a English
590 $a School code: 1543
650 4 $a Metals. $3 601053
650 4 $a Acids. $3 922327
650 4 $a Reagents. $3 3683752
650 4 $a Palladium. $3 644757
650 4 $a Chemistry. $3 516420
650 4 $a Design. $3 518875
650 4 $a Phenols. $3 915439
650 4 $a Cobalt. $3 3682549
650 4 $a Inorganic chemistry. $3 3173556
690 $a 0485
690 $a 0389
690 $a 0488
710 2 $a The University of Manchester (United Kingdom). $e degree granting institution. $3 3759026
720 1 $a Amat, Jorge Bures $e degree supervisor.
720 1 $a Larrosa, Igor $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 83-10B.
790 $a 1543
791 $a Ph.D.
792 $a 2021
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29051717