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Nuclear Speckles: The Intersection o...

Dion, William Aaron,

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Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis // William Aaron Dion.
Author:	Dion, William Aaron,
Description:	1 electronic resource (256 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
Subject:	Cellular biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31933938
ISBN:	9798314868102

Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /
Dion, William Aaron,

Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /William Aaron Dion. - 1 electronic resource (256 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

The foundational question of my dissertation research was "how do ~12-hour biological rhythms intersect with proteostasis?". I begin with a review of ultradian chronobiology (Chapter 1) that will equip the reader with the relevant background information to understand the following two chapters. Next, I present our study linking the nuclear speckle's ~12-hour rhythms of liquidliquid phase separation dynamics to ultradian rhythms of proteostasis gene expression (Chapter 2). Then, I report our research establishing the liquid-liquid phase separation dynamics of the nuclear speckle as a druggable target to modulate the cell's ability to maintain a balanced proteome (Chapter 3). Finally, I provide concluding remarks that I hope leave the reader excited for the future of nuclear speckle research. This dissertation coherently explains the importance of ultradian chronobiology to organismal health, and details how the simple aforementioned question led to the establishment of the nuclear speckle as a druggable target to boost cellular proteostasis.

English

ISBN: 9798314868102Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Chronobiology

Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /
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245 1 0 $a Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis / $c William Aaron Dion.
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300 $a 1 electronic resource (256 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
500 $a Advisors: Zhu, Bokai Committee members: Benos, Panayiotis V.; Finkel, Toren; Gurkar, Aditi; Vasudevan, Deepika.
502 $b Ph.D. $c University of Pittsburgh $d 2025.
520 $a The foundational question of my dissertation research was "how do ~12-hour biological rhythms intersect with proteostasis?". I begin with a review of ultradian chronobiology (Chapter 1) that will equip the reader with the relevant background information to understand the following two chapters. Next, I present our study linking the nuclear speckle's ~12-hour rhythms of liquidliquid phase separation dynamics to ultradian rhythms of proteostasis gene expression (Chapter 2). Then, I report our research establishing the liquid-liquid phase separation dynamics of the nuclear speckle as a druggable target to modulate the cell's ability to maintain a balanced proteome (Chapter 3). Finally, I provide concluding remarks that I hope leave the reader excited for the future of nuclear speckle research. This dissertation coherently explains the importance of ultradian chronobiology to organismal health, and details how the simple aforementioned question led to the establishment of the nuclear speckle as a druggable target to boost cellular proteostasis.
546 $a English
590 $a School code: 0178
650 4 $a Cellular biology. $3 3172791
650 4 $a Bioinformatics. $3 553671
650 4 $a Molecular biology. $3 517296
653 $a Chronobiology
653 $a Proteostasis
653 $a Nuclear speckle research
653 $a Cellular proteostasis
653 $a Ultradian chronobiology
690 $a 0379
690 $a 0715
690 $a 0307
710 2 $a University of Pittsburgh. $b Integrative Systems Biology. $e degree granting institution. $3 3823585
720 1 $a Zhu, Bokai $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-11B.
790 $a 0178
791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31933938